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Therapeutic and Nutraceutical Values of Functional Foods or Compounds
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Therapeutic and Nutraceutical Values of Functional Foods or Compounds

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 2601

Special Issue Editors

Dr. Sibao Chen

E-Mail Website
Guest Editor
Department of Food Science and Nutrition (FSN), The Hong Kong Polytechnic University, Hong Kong 999077, China
Interests: functional food; natural compound; food bioactive compound; traditional Chinese medicine; quality control; anticancer; drug development
Special Issues, Collections and Topics in MDPI journals
Dr. Guo-Qing Chen

E-Mail Website
Guest Editor
The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen 518000, China
Interests: functional food; natural compound; food bioactive compound; traditional Chinese medicine; biological activity; anticancer; cell death; drug development

Special Issue Information

Dear Colleagues,

We are pleased to invite you to submit your research papers to this Special Issue, “Therapeutic and Nutraceutical Values of Functional Foods or Compounds”. Functional foods or compounds provide more than just essential nutrition; they have the potential to support specific physiological functions, leading to medicinal and health advantages in the prevention, management, and even treatment of various diseases. Consequently, the development of therapeutic treatments and pharmaceuticals derived from functional foods or compounds becomes a viable consideration.

This Special Issue aims to present the latest and most promising insights concerning the health benefits and underlying mechanisms of functional foods or compounds. We anticipate that this Special Issue will serve as a timely reference for researchers who are interested in the exploration and development of functional foods or compounds.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Functional foods or compounds for disease prevention and management;
  • Gut health and functional foods or compounds;
  • Probiotics, prebiotics, and microbial functional foods;
  • Foods and herbal medicines;
  • Bioactive compounds in functional foods and herbs;
  • Free radicals, antioxidants, and functional foods or compounds.

Dr. Sibao Chen
Dr. Guo-Qing Chen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • functional food
  • formulations
  • nutraceutical
  • natural compound
  • probiotic
  • biological activities
  • quality control
  • antioxidant

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

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Research

19 pages, 2921 KiB  
Article
Identification of the Metabolites of Both Formononetin in Rat Hepatic S9 and Ononin in Rat Urine Samples and Preliminary Network Pharmacology Evaluation of Their Main Metabolites
by Yu-Zhu Yang, Tao Wang, Qi-Lei Chen, Hu-Biao Chen, Qian-Song He and Ya-Zhou Zhang
Molecules 2023, 28(21), 7451; https://doi.org/10.3390/molecules28217451 - 6 Nov 2023
Cited by 2 | Viewed by 1695
Abstract
Astragalus membranaceus is a traditional Chinese medicine derived from the roots of Astragalus membranaceus (Fisch.) Bge., which has the same medicinal and edible uses in China. It is also widely used in daily food, and its pharmacological effects mainly include antioxidant effects, vascular [...] Read more.
Astragalus membranaceus is a traditional Chinese medicine derived from the roots of Astragalus membranaceus (Fisch.) Bge., which has the same medicinal and edible uses in China. It is also widely used in daily food, and its pharmacological effects mainly include antioxidant effects, vascular softening effects, etc. Currently, it is increasingly widely used in the prevention of hypertension, cerebral ischemia, and stroke in China. Formononetin and its glucopyranoside (ononin) are both important components of Astragalus membranaceuss and may play important roles in the treatment of cardiovascular diseases (CVDs). This study conducted metabolic studies using formononectin and its glucopyranoside (ononin), including a combination of the in vitro metabolism of Formonetin using rat liver S9 and the in vivo metabolism of ononin administered orally to rats. Five metabolites (Sm2, 7, 9, 10, and 12) were obtained from the solution incubated with formononetin and rat hepatic S9 fraction using chromatographic methods. The structures of the five metabolites were elucidated as (Sm2)6,7,4′-trihydroxy-isoflavonoid; (Sm7)7,4′-dihydroxy-isoflavonoid; (Sm9)7,8,4′-trihydroxy-isoflavonoid; (Sm10)7,8,-dihydroxy-4′-methoxy-isoflavonoid; and (Sm12)6,7-dihydroxy-4′-methoxy- isoflavonoid on the basis of UV, NMR, and MS data. Totally, 14 metabolites were identified via HPLC-DAD-ESI-IT-TOF-MSn analysis, from which the formononetin was incubated with rat hepatic S9 fraction, and the main metabolic pathways were hydroxylation, demethylation, and glycosylation. Then, 21 metabolites were identified via HPLC-DAD-ESI-IT-TOF-MSn analysis from the urine samples from SD rats to which ononin was orally administered, and the main metabolic pathways were glucuronidation, hydroxylation, demethylation, and sulfonation. The main difference between the in vitro metabolism of formononetin and the in vivo metabolism of ononin is that ononin undergoes deglycemic transformation into Formonetin in the rat intestine, while Formonetin is absorbed into the bloodstream for metabolism, and the metabolic products also produce combined metabolites during in vivo metabolism. The six metabolites obtained from the aforementioned separation indicate the primary forms of formononetin metabolism, and due to their higher contents of similar isoflavone metabolites, they are considered the main active compounds that are responsible for pharmacological effects. To investigate the metabolites of the active ingredients of formononetin in the rat liver S9 system, network pharmacology was used to evaluate the cardiovascular disease (CVD) activities of the six primary metabolites that were structurally identified. Additionally, the macromolecular docking results of six main components and two core targets (HSP90AA1 and SRC) related to CVD showed that formononetin and its main metabolites, Sm10 and Sm12, may have roles in CVD treatment due to their strong binding activities with the HSP90AA1 receptor, while the Sm7 metabolite may have a role in CVD treatment due to its strong binding activity with the SRC receptor. Full article
(This article belongs to the Special Issue Therapeutic and Nutraceutical Values of Functional Foods or Compounds)
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