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Advances in Chemistry of Cosmetics

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 2375

Special Issue Editor


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Guest Editor
Department of Chemistry and Cosmetics, Jeju National University, Jeju 63243, Republic of Korea
Interests: natural product chemistry; melanogenesis; skin inflammation; anti-aging; hair growth
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The modern cosmetics industry is increasingly innovative and scientific, employing a variety of methodologies and technologies. With these scientific advancements, scientifically validated and eco-friendly cosmetic ingredients have become integral to maintaining healthy skin, scalp, hair, and nails. For this reason, natural products and their derivatives are an interesting and largely unexplored source of new functional ingredients. The global market demand for natural ingredients, such as plant extracts with skincare applications and other human health uses, is also increasing. In fact, many companies around the world are striving to develop inhibitors or activators associated with oxidation, melanogenesis, inflammation, hair growth, and obesity. Additionally, more mindful consumers who use such health products tend to carefully review the mechanisms of action of these inhibitors or activators.

This Special Issue on "Advances in the Chemistry of Cosmetics" serves as a platform not only for presenting novel data on natural products and compounds with human health benefits (acting either at the enzymatic or cellular level) through original papers and short communications but also for providing an overview of the current knowledge in this field through reviews.

Prof. Dr. Chang-Gu Hyun
Guest Editor

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Keywords

  • melanocytes (melanogenesis)
  • fibroblasts (anti-wrinkles)
  • papilla (hair growth)
  • keratinocytes (skin health)
  • macrophages (inflammation)
  • adipocytes (obesity)
  • natural products
  • organic synthesis
  • enzyme inhibitors
  • molecular docking

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Published Papers (2 papers)

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Research

13 pages, 2681 KiB  
Article
Phenolic Contents and Antioxidant Properties of Bauhinia rufescens, Ocimum basilicum and Salvadora persica, Used as Medicinal Plants in Chad
by Hissein Hassan Abdel-razakh, Gaymary George Bakari, Jin-Soo Park, Cheol-Ho Pan and Abubakar Shaaban Hoza
Molecules 2024, 29(19), 4684; https://doi.org/10.3390/molecules29194684 - 2 Oct 2024
Viewed by 998
Abstract
The plants Bauhinia rufescens, Ocimum basilicum and Salvadora persica are well known in traditional African medicine, and particularly in traditional Chadian medicine. They are commonly used to treat infectious diseases, inflammatory diseases, fevers, gastroenteritis and other medical conditions. The aim of this [...] Read more.
The plants Bauhinia rufescens, Ocimum basilicum and Salvadora persica are well known in traditional African medicine, and particularly in traditional Chadian medicine. They are commonly used to treat infectious diseases, inflammatory diseases, fevers, gastroenteritis and other medical conditions. The aim of this study was to perform a phytochemical screening to determine the antioxidant properties of different extracts and fractions from the three plants. Ethanolic extracts and solvent fractions were prepared and analyzed for total phenolic content (TPC), total flavonoid content (TFC) and total tannin content (TTC). LC-MS and an online screening HPLC-ABTS system identified phytochemicals with antioxidant activities. DPPH and ABTS reduction methods were used to test the extracts and fractions for their antioxidant potential. The results showed that the TPC of O. basilicum was higher than that of B. rufescens, ranging from 64.70 ± 5.2 to 411.16 ± 8.11 mgGAE/g DW. B. rufescens extracts and fractions, on the other hand, showed higher TFC, ranging from 69.5 ± 5.3 to 408.26 ± 8.42 mgQE/g DW, and higher TTC, ranging from 4.57 ± 2.45 to 62.19 ± 4.7 mgTAE/g DW. The maximum TPC, TFC and TTC in both plants were recorded in the ethyl acetate fractions. S. persica extracts and fractions showed a very low quantity of TPC, TFC and TTC. Based on LC-MS and HPLC-ABTS analysis, rosmarinic acid was identified as the major component in the extracts and all fractions of O. basilicum, and epicatechin, procyanidin B and quercetin were found in B. rufescens. S. persica did not exhibit specific substances with antioxidant activity and was therefore not considered for further assays. DPPH and ABTS results showed that ethyl acetate fractions of B. rufescens and O. basilicum have the strongest antioxidant activities. This study indicates that B. rufescens and O. basilicum are good sources of phytochemicals with antioxidant properties, suitable for medicinal use in Chadian communities. Additionally, the antioxidant-rich extracts from these plants hold significant potential for cosmetic development, enhancing skin health and protecting against oxidative-stress-induced damage. Full article
(This article belongs to the Special Issue Advances in Chemistry of Cosmetics)
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18 pages, 3302 KiB  
Article
Identification of Cellular Isoschaftoside-Mediated Anti-Senescence Mechanism in RAC2 and LINC00294
by Yun Haeng Lee, Byeong Hyeon So, Kyeong Seon Lee, Myeong Uk Kuk, Ji Ho Park, Jee Hee Yoon, Yoo Jin Lee, Du Yeol Kim, Min Seon Kim, Hyung Wook Kwon, Youngjoo Byun, Ki Yong Lee and Joon Tae Park
Molecules 2024, 29(17), 4182; https://doi.org/10.3390/molecules29174182 - 4 Sep 2024
Viewed by 1033
Abstract
As cellular senescence, reactive oxygen species (ROS) accumulate excessively, causing cellular damage. Flavonoids derived from natural products are known for their antioxidant effects and their ability to delay cellular senescence. Previous studies have attempted to mitigate cellular senescence using flavonoids from natural sources. [...] Read more.
As cellular senescence, reactive oxygen species (ROS) accumulate excessively, causing cellular damage. Flavonoids derived from natural products are known for their antioxidant effects and their ability to delay cellular senescence. Previous studies have attempted to mitigate cellular senescence using flavonoids from natural sources. However, the detailed mechanisms and regulatory targets of some flavonoids exhibiting antioxidant effects have not been fully elucidated. Therefore, we screened a library of flavonoids for antioxidant properties. Isoschaftoside, a glycosidic flavonoid, significantly reduced ROS levels in senescent cells. It was found that mitochondrial function was restored, and dependence on glycolysis was reduced in senescent cells treated with isoschaftoside. Additionally, we identified that isoschaftoside suppresses ROS by reducing the expression of RAC2 and LINC00294 in senescent cells. Taken together, this study establishes a novel mechanism for ROS inhibition and the regulation of cellular senescence by isoschaftoside. Our findings contribute important insights to antioxidant and anti-senescence research. Full article
(This article belongs to the Special Issue Advances in Chemistry of Cosmetics)
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