Novel G-Quadruplex Ligands: From Synthesis to Evaluation
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (5 December 2022) | Viewed by 2827
Special Issue Editor
Special Issue Information
Dear Colleagues,
G-quadruplexes (G4s) are four-stranded nucleic acid structures that can fold into guanine-rich sequences. These polymorphous secondary structures have received much attention in medicinal chemistry thanks to their occurrence in key regions of the genome. Evidence suggests that G4s affect genomic instability, affect telomerase dysfunction, and behave as transcriptional repressor elements. Thus, targeting G4 structures has emerged as an alternative strategy for the potential treatment of many diseases. Following this observation, several G-quadruplex-binding molecules have been developed for therapeutic purposes. This Special Issue will focus on the rational design of new selective molecular ligands able to interact, stabilize, alkylate, and cleave G4s.
Dr. Filippo Doria
Guest Editor
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Keywords
- G-quadruplex
- selective ligands
- chemotype diversity
- functional tools
- biophysical assay
- biological activity
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