Microbial Natural Products in the Era of Genome- and Metabolome-Mining (2nd Edition)
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 2835
Special Issue Editors
Interests: mass spectrometry of natural products; myxobacteria; biosynthetic pathways; genome- and metabolome mining
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Microbial natural products have a strong history as valuable lead structures for drug discovery in areas ranging from infectious diseases and cancer therapy to agriculture. Thus, great efforts are constantly being made to find novel natural products —also referred to as secondary metabolites or specialized metabolites —from diverse microorganisms. While activity-guided approaches have yielded most of the bioactive secondary metabolites known to date, many of these “low-hanging fruits” have now been harvested. Furthermore, the number of molecule families characterized so far is significantly lower than expected from the analysis of genome sequence information for many microbes. Therefore, contemporary natural products discovery is increasingly driven by genomics- and metabolomics-based strategies in order to provide novel candidate molecules for the development of new drugs. This Special Issue highlights recent studies where genome- and metabolome-mining approaches were instrumental in uncovering and characterizing new natural products. Contributions should include a description of how genome information or metabolomics methods were helpful, e.g., as part of the analytical setup for compound discovery, to support structure elucidation, for connecting molecules to biosynthetic genes, to establish a model for biosynthesis, to shed light on specific enzymatic steps during compound formation, for production improvement, or to gain insights into bioactivity, host self-resistance, and the mode-of-action of the investigated molecules.
Dr. Daniel Krug
Dr. Joachim J. Hug
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- natural products
- drug discovery
- secondary metabolites
- biosynthesis
- genome-mining
- metabolomics
- antibiotics
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
