Combating Cancer Stemness and Drug Resistance with Natural-Product Derived Lead Structures
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".
Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 727
Special Issue Editors
Interests: structure–activity relationships; anti-inflammatory natural products; drug discovery; molecular pharmacological mechanisms; tumor microenvironment; drug resistance
Special Issues, Collections and Topics in MDPI journals
Interests: natural product chemistry; medicinal and analytical chemistry; computational chemistry; drug discovery and development; neurodegenerative diseases; solid phase peptide synthesis (SPPS)
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Tumor development encompasses a complex interplay of abnormal cell proliferation and differentiation and a high degree of cellular heterogeneity and epithelial–mesenchymal transition (EMT). To date, targeted drug therapy and chemotherapy are the main pharmaceutical treatment options. However, long-term therapies usually lead to acquired drug resistance via multiple mechanisms resulting in poor prognosis. Recently, evidence has shown that cancer stem cells (CSCs) are a type of cancer cells with a great potential of self-renewal which play a huge role in tumor metastasis and drug resistance. Low sensitivity of cancer stem cells toward regular chemotherapy strategies is, amongst others, one important issue in the field of cancer remedy. Thus, the concept of elimination or “re-sensitization” of resistant cells within the heterogenous tumor cell population with natural compounds or synthetic derivatives to increase chemotherapy success rates by combating drug resistance and cancer stemness is promising.
This Special Issue of Molecules on “Combating Cancer Stemness and Drug Resistance with Natural-Product-Derived Lead Structures” will include articles and reviews focused on the most recent advances in the identification and pharmacological characterization of natural products or novel synthetic lead structures to target drug-resistant cancer cells and resistance-promoting tumor-associated cells within the tumor microenvironment or cancer stem cells.
Prof. Dr. Nicole Teusch
Dr. Komal Kalani
Guest Editors
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Keywords
- multidrug resistance
- chemotherapy failure
- reversal of drug resistance
- tumor microenvironment
- cellular heterogeneity
- cancer stem cells
- epithelial–mesenchymal transition (EMT)
- metastasis
- apoptosis
- DNA damage response (DDR)
- autophagy
- epigenetics
- epigenetic regulation in cancer
- drug discovery
- natural products
- natural-product-derived lead structures
- structure–activity relationships
- virtual screening
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