Drug Discovery and Development Based on Native/Engineered Microorganisms
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 August 2020) | Viewed by 11492
Special Issue Editors
Interests: antibiotics; bio-active molecules; nanoparticles; drug development and discovery; chemical biology
Special Issues, Collections and Topics in MDPI journals
Interests: transition metal catalyzed reactions; synthetic methodologies to obtain bioactive molecules
Special Issues, Collections and Topics in MDPI journals
Interests: drug discovery; computational techniques; anticancer agents; aromatase inhibitors
Special Issues, Collections and Topics in MDPI journals
Interests: natural product chemistry; medicinal and analytical chemistry; computational chemistry; drug discovery and development; neurodegenerative diseases; solid phase peptide synthesis (SPPS)
Special Issues, Collections and Topics in MDPI journals
Interests: drug discovery; medicinal chemistry; organic synthesis; enzyme inhibitors; immunomodulators; antimicrobials; anticancer agents; antioxidants; cinnamic acid derivatives
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Most of the molecules utilized as drugs are obtained from microorganisms. These molecules can be natural compounds or their derivatives. In most cases, the useful compounds are obtained at low titers or are cryptic, so various metabolic engineering/genetic engineering approaches are utilized to enhance the production titer. Recent advances in the isolation/culture of previously uncultivable microorganisms and the availability of versatile genetic engineering approaches have taken microbial engineering to the next horizon. However, in cases where the molecules are not accessible from the native host under natural conditions, alternative/heterologous production platforms are utilized. Approaches such as “genome mining” have enabled the connection of secondary metabolites to their respective biosynthetic genetic codes, whereas the application of metabolic engineering, synthetic biology tools, and genome engineering has contributed remarkably to drug development based on engineered microorganisms. Hence, this Special Issue will cover all aspects of drug discovery and development utilizing native/engineered microorganisms.
Potential topics of interest include, but are not limited to:
- Advances in the isolation/characterization of microorganisms with potential compounds;
- Isolation/characterization of novel bioactive molecules;
- Metabolic engineering, synthetic biology, and genome engineering for modulating the production titer from native/heterologous hosts;
- Chemical/biological approaches for the production of novel compounds;
- Bioactivities and mechanisms of action of microbe-derived compounds;
Dr. Dipesh Dhakal
Guest Editor
Manuscript Submission Information
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Keywords
- drug discovery
- natural microbial products
- microorganisms
- synthetic biology
- metabolic engineering
- bioactivity
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