Drug Discovery from Microorganisms
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".
Deadline for manuscript submissions: closed (28 February 2019) | Viewed by 4859
Special Issue Editors
Interests: natural products; actinomycetes; streptomyces; flavonoids; antibiotics; anticancer drugs; metabolic engineering; synthetic biology; enzymatic modifications
Special Issues, Collections and Topics in MDPI journals
Interests: antibiotics; bio-active molecules; nanoparticles; drug development and discovery; chemical biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Natural products (NPs) biosynthesized by microorganisms are prominent source of compounds with pharmacological values, thus established as the best starting point in the drug discovery process. Generally these compounds are biosynthesized in microorganisms through versatile metabolic pathways. They are often termed as “secondary metabolites” (SM) as they are synthesized like primary metabolites by producer organisms but may not be essential for their own metabolic processes. These SM or their derivatives are most frequently utilized as “drug leads” for the treatment of different disease conditions. Different biological approaches such as the utilization of synthetic biology tools, metabolic engineering techniques and precise enzymatic modifications have assisted in developing novel molecules with novel structural/functional diversities from the producer organism. This Special Issue aims to include research or review papers focused on key aspects of drug discovery from micro-organisms, including the isolation and characterization of novel structures, the study of biosynthetic mechansims, or the assessment of the biological activities of diverse microbe-derived molecules.
Prof. Jae Kyung SohngDr. Dipesh Dhakal
Guest Editors
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Keywords
- Microbe-derived biomolecules
- Isolation and characteriztion
- Biosynthetic mechansims
- Biological activities
- Structural modifications
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