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Stereoselective Organic Synthesis: New Tools, New Perspectives

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 1962

Special Issue Editor


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Guest Editor
School of Science and Technology, Chemistry Division, University of Camerino, Camerino, Italy
Interests: stereoselective synthesis; Lewis acid catalysis; multicomponent reactions; small molecules; heterocycle synthesis; green chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Organic chemistry has explored its potential, especially in the field of stereoselective synthesis. Nowadays, there is no doubt that the biological activity of each enantiomer in living beings is different, and consequently, the need for enantiopure substances to be used as pharmaceuticals as well as pesticides, insecticides, flavors, and fragrances is increasing. Furthermore, sustainability is currently a major issue , meaning that the development of chiral catalysts that allow for huge amounts of enantioenriched or enantiopure substances with even smaller amounts of catalyst and even higher turnover number to be prepared has become a pressing issue.

These needs have prompted synthetic organic chemists to achieve deep insight and comprehension of all of the factors influencing the outcomes of compound synthesis. From this point of view, the dissemination of the results obtained in the field of stereoselective synthesis offers the community new opportunities to widen our knowledge of mechanisms and methods and to enrich the collection of the synthetic tools available. We welcome selected papers that are able to introduce new perspectives to increase our comprehension of the effects involved in the mechanism of the stereoselective synthesis of pharmaceuticals, pesticides, insecticides, flavors and fragrances, and chiral catalysts via their application.

Dr. Cimarelli Cristina
Guest Editor

Manuscript Submission Information

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Keywords

  • stereoselective synthesis
  • asymmetric catalysis
  • asymmetric organocatalysis
  • enantiodifferentiation
  • reaction mechanism
  • chiral auxiliaries
  • chiral complexes
  • synthetic methodologies

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Published Papers (1 paper)

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Research

20 pages, 1872 KiB  
Communication
Enantioselective, Decarboxylative (3+2)-Cycloaddition of Azomethine Ylides and Chromone-3-Carboxylic Acids
by Ewelina Kowalska, Lesław Sieroń and Anna Albrecht
Molecules 2022, 27(20), 6809; https://doi.org/10.3390/molecules27206809 - 11 Oct 2022
Cited by 1 | Viewed by 1555
Abstract
Herein, we describe the synthesis of a variety of chiral hybrid pyrrolidine-chromanone polycyclic derivatives. A convenient (3+2)-annulation of azomethine ylides with chromone-3-carboxylic acid realized under Brønsted base catalysis produced highly functionalized products in high yields with good stereoselectivities through asymmetric, intermolecular, and decarboxylative [...] Read more.
Herein, we describe the synthesis of a variety of chiral hybrid pyrrolidine-chromanone polycyclic derivatives. A convenient (3+2)-annulation of azomethine ylides with chromone-3-carboxylic acid realized under Brønsted base catalysis produced highly functionalized products in high yields with good stereoselectivities through asymmetric, intermolecular, and decarboxylative (3+2)-cyclization. Full article
(This article belongs to the Special Issue Stereoselective Organic Synthesis: New Tools, New Perspectives)
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