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Molecules
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Chemical Approaches in Water Treatment: Environmental Toxicology and Hygiene Perspectives
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Chemical Approaches in Water Treatment: Environmental Toxicology and Hygiene Perspectives

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Green Chemistry".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 559

Special Issue Editors

Dr. Antonietta Siciliano

E-Mail Website
Guest Editor
Department of Biology, University of Naples Federico II, 80126 Naples, Italy
Interests: terrestrial, marine and freshwater ecotoxicity; water treatment; emerging contaminants; rare earth elements (REE); human and environmental health
Special Issues, Collections and Topics in MDPI journals
Dr. Lorenzo Saviano

E-Mail
Guest Editor Assistant
Department of Biology, University of Naples Federico II, 80126 Naples, Italy
Interests: terrestrial, marine and freshwater ecotoxicity; water treatment; emerging contaminants; rare earth elements (REE); human and environmental health

Special Issue Information

Dear Colleagues,

This Special Issue explores innovative chemical methods for water treatment, focusing on their implications for environmental toxicology and hygiene. It aims to highlight advancements in removing contaminants from water while assessing the potential environmental and health impacts of these technologies. Topics may include the development of eco-friendly chemicals, the evaluation of toxicological risks associated with water pollutants, and the integration of hygiene practices in ensuring safe water quality for public health, which should focus on the influence of water treatment, pumping, or storage technologies on the chemical and microbiological safety of drinking water, rather than on legislation or other aspects. Researchers are invited to contribute studies that advance the intersection of water treatment technologies, environmental safety, and human health.

Dr. Antonietta Siciliano
Guest Editor

Dr. Lorenzo Saviano
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • water treatment technologies
  • environmental toxicology
  • hygiene practices
  • chemical contaminants
  • eco-friendly water treatment
  • public health safety
  • toxicological risk assessment
  • pollutant removal methods

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Published Papers (1 paper)

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Research

10 pages, 1648 KiB  
Article
Ecotoxicity and Mutagenicity Assessment of Novel Antifungal Agents VT-1161 and T-2307
by Edith Guadalupe Padilla Suarez, Antonietta Siciliano, Marisa Spampinato, Angela Maione, Marco Guida, Giovanni Libralato and Emilia Galdiero
Molecules 2024, 29(19), 4739; https://doi.org/10.3390/molecules29194739 - 7 Oct 2024
Viewed by 482
Abstract
Antifungal substances are essential for managing fungal infections in humans, animals, and plants, and their usage has significantly increased due to the global rise in fungal infections. However, the extensive application of antifungal agents in pharmaceuticals, personal care products, and agriculture has led [...] Read more.
Antifungal substances are essential for managing fungal infections in humans, animals, and plants, and their usage has significantly increased due to the global rise in fungal infections. However, the extensive application of antifungal agents in pharmaceuticals, personal care products, and agriculture has led to their widespread environmental dissemination through various pathways, such as excretion, improper disposal, and agricultural runoff. Despite advances in wastewater treatment, many antifungal compounds persist in the environment, affecting non-target organisms and contributing to resistance development. This study investigates the environmental impact of two novel antifungal agents, VT-1161 and T-2307, recently introduced as alternatives for treating resistant Candida spp. We assessed their ecotoxicity and mutagenicity using multiple bioassays: immobilization of Daphnia magna, growth inhibition of Raphidocelis subcapitata, luminescence inhibition of Aliivibrio fischeri, and mutagenicity on Salmonella typhimurium strain TA100. Results indicate that both VT-1161 and T-2307 exhibit lower toxicity compared to existing antifungal compounds, with effective concentrations (EC50) causing 50% response ranging from 14.34 to 27.92 mg L−1. Furthermore, both agents were classified as less hazardous based on the Globally Harmonized System of Classification and Labeling of Chemicals. Despite these favorable results, further research is needed to understand their environmental behavior, interactions, and potential resistance development among non-target species. Our findings highlight the importance of comprehensive environmental risk assessments to ensure the sustainable use of new antifungal agents. Full article
(This article belongs to the Special Issue Chemical Approaches in Water Treatment: Environmental Toxicology and Hygiene Perspectives)
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