Synthetic and Nature Inspired Anti-inflammatory Small Molecules
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 3204
Special Issue Editor
Interests: drug discovery; organic synthesis; multicomponent reactions; cancer and inflammation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Although inflammation may be considered the protective response of an organism to a variety of biological, physical, and chemical injuries, it may contribute, when disregulated, to a wide range of pathological conditions, including cancer.
Among the many factors involved in this complex network of biological events, the bioactive prostanoids PGE2 represent key effectors, able to activate specific signaling pathways associated with crucial cellular processes such as cell proliferation, angiogenesis, and inflammation. Hence, the deep involvement of PGE2 in these two closely associated pathways—for example, inflammation and cancer—justify the many efforts undertaken, in the last few decades, in this research area, both in academia and industry.
Many projects, applying different approaches, have been focused on the identification of new molecular entities able to inhibit PGE2 production and possibly representing a more promising therapeutic option compared to the traditional and widespread non-steroidal anti-inflammatory drugs (NSAIDs) commonly used in inflammatory pathologies.
The main aim of this Special Issue is to collect and illustrate the recent developments in the field of the isolation, structural characterization, rational design, synthesis, and biological evaluation of compounds related to PGE2 inhibition as promising drug candidates.
We invite all researchers working in this field to contribute original articles presenting the results of their research endeavors. Reviews covering the main aspects of the topic are also welcome.
Prof. Dr. Ines Bruno
Guest Editor
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Keywords
- Organic Synthesis
- Natural Products
- Medicinal Chemistry
- Inflammation
- Cancer
- Drug Design
- Prostanoids
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