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Molecules
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Bioprospecting of New Natural Organic Compounds and Their Bioactivity Spectrum
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Bioprospecting of New Natural Organic Compounds and Their Bioactivity Spectrum

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 4957

Special Issue Editors

Prof. Moses K. Langat

E-Mail Website
Guest Editor
Jodrell Laboratory, Richmond, UK
Interests: identification of biochemicals from plants and fungi; structure determination; development of biochemicals to commercially valuable products; natural products as pharmaceuticals; natural products for agricultural management; natural products for cosmetic applications
Special Issues, Collections and Topics in MDPI journals
Dr. Sianne L. Schwikkard

E-Mail Website
Guest Editor
School of Life Sciences, Pharmacy and Chemistry, Kingston University, Kingston, UK
Interests: isolation and characterization of natural products from plant sources; synthesis of natural products; analysis of bioactivity of natural products
Dr. Derese Solomon

E-Mail Website
Guest Editor
Department of Chemistry, University of Nairobi, Nairobi, Kenya
Interests: natural products chemistry; medicinal chemistry; organic chemistry; computer-aided drug design

Special Issue Information

Dear Colleagues,

Natural products have played a significant role in human health and wellbeing for centuries. There remains a vast unexplored biodiversity with many new and significant discoveries being made each year. The bioprospecting of new natural organic compounds has led to the identification of useful biochemicals that are used as medicines and foods, and in veterinary medicine, agriculture, cosmetics and environment.
This Special Issue will consider research and review articles that present new natural compounds from a diverse range of biological sources including plants, bacteria, fungi and animals. Works should give the structures of the new compounds, and could include their synthesis if relevant as well as their in vitro and in vivo biological activities.

Dr. Moses K. Langat
Dr. Sianne L. Schwikkard
Dr. Derese Solomon
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • new natural compounds
  • bioactive natural compounds
  • phytochemistry
  • fungal chemistry
  • drug discovery from natural compounds
  • biological screening
  • in vitro and in vivo screening
  • synthesis of natural products

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Published Papers (2 papers)

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Research

8 pages, 1148 KiB  
Communication
Coumarinolignoid and Indole Alkaloids from the Roots of the Hybrid Plant Citrus × paradisi Macfad (Rutaceae)
by Fanny-Aimée Essombe Malolo, Ariane Dolly Kenmogne Kouam, Judith Caroline Ngo Nyobe, Lidwine Ngah, Marcel Frese, Jean Claude Ndom, Moses K. Langat, Bruno Ndjakou Lenta, Dulcie A. Mulholland, Norbert Sewald and Jean Duplex Wansi
Molecules 2023, 28(3), 1078; https://doi.org/10.3390/molecules28031078 - 20 Jan 2023
Viewed by 1853
Abstract
A phytochemical investigation of the roots of Citrus × paradisi Macfad. (Rutaceae) led to the isolation of two new compounds, namely 1-formyl-5-hydroxy-N-methylindolin-1-ium (1) and decyloxycleomiscosin D (2), along with ten known compounds: 1,1-dimethylpyrrolidin-1-ium-2-carboxylate (3), furan-2,3-diol [...] Read more.
A phytochemical investigation of the roots of Citrus × paradisi Macfad. (Rutaceae) led to the isolation of two new compounds, namely 1-formyl-5-hydroxy-N-methylindolin-1-ium (1) and decyloxycleomiscosin D (2), along with ten known compounds: 1,1-dimethylpyrrolidin-1-ium-2-carboxylate (3), furan-2,3-diol (4), 5-methoxyseselin (5), umbelliferone (6), scopoletin (7), citracridone I (8), citracridone II (9), citracridone III (10), limonin (11) and lupeol (12). The structures were determined through the comprehensive spectroscopic analysis of 1D and 2D NMR and EI- and ESI-MS, as well as a comparison with the published data. Notably, compounds 3 and 4 from the genus Citrus are reported here for the first time. In addition, the MeOH extract of the roots and compounds 1–7 were screened against the human adenocarcinoma alveolar basal epithelial cell line A549 and the Caucasian prostate adenocarcinoma cell line PC3 using the MTT assay. While the extract showed significant activity, with IC50 values of 35.2 and 38.1 µg/mL, respectively, compounds 1–7 showed weak activity, with IC50 values of 99.2 to 250.2 µM and 99.5 to 192.7 µM, respectively. Full article
(This article belongs to the Special Issue Bioprospecting of New Natural Organic Compounds and Their Bioactivity Spectrum)
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18 pages, 3011 KiB  
Article
Biodereplication of Antiplasmodial Extracts: Application of the Amazonian Medicinal Plant Piper coruscans Kunth
by Pedro G. Vásquez-Ocmín, Jean-François Gallard, Anne-Cécile Van Baelen, Karine Leblanc, Sandrine Cojean, Elisabeth Mouray, Philippe Grellier, Carlos A. Amasifuén Guerra, Mehdi A. Beniddir, Laurent Evanno, Bruno Figadère and Alexandre Maciuk
Molecules 2022, 27(21), 7638; https://doi.org/10.3390/molecules27217638 - 7 Nov 2022
Cited by 3 | Viewed by 2294
Abstract
Improved methodological tools to hasten antimalarial drug discovery remain of interest, especially when considering natural products as a source of drug candidates. We propose a biodereplication method combining the classical dereplication approach with the early detection of potential antiplasmodial compounds in crude extracts. [...] Read more.
Improved methodological tools to hasten antimalarial drug discovery remain of interest, especially when considering natural products as a source of drug candidates. We propose a biodereplication method combining the classical dereplication approach with the early detection of potential antiplasmodial compounds in crude extracts. Heme binding is used as a surrogate of the antiplasmodial activity and is monitored by mass spectrometry in a biomimetic assay. Molecular networking and automated annotation of targeted mass through data mining were followed by mass-guided compound isolation by taking advantage of the versatility and finely tunable selectivity offered by centrifugal partition chromatography. This biodereplication workflow was applied to an ethanolic extract of the Amazonian medicinal plant Piper coruscans Kunth (Piperaceae) showing an IC50 of 1.36 µg/mL on the 3D7 Plasmodium falciparum strain. It resulted in the isolation of twelve compounds designated as potential antiplasmodial compounds by the biodereplication workflow. Two chalcones, aurentiacin (1) and cardamonin (3), with IC50 values of 2.25 and 5.5 µM, respectively, can be considered to bear the antiplasmodial activity of the extract, with the latter not relying on a heme-binding mechanism. This biodereplication method constitutes a rapid, efficient, and robust technique to identify potential antimalarial compounds in complex extracts such as plant extracts. Full article
(This article belongs to the Special Issue Bioprospecting of New Natural Organic Compounds and Their Bioactivity Spectrum)
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