Combining Synthesis and Biosynthesis to Access Complex Molecules
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".
Deadline for manuscript submissions: closed (30 January 2020) | Viewed by 4844
Special Issue Editors
Special Issue Information
Dear Colleagues,
The construction of complex molecules has always benefited greatly from the field of biosynthesis. This can be clearly seen in the inspired biomimetic syntheses of complex molecules like tropinone, the daphnyphilum alkaloids, and the endiandric acids, and more recently in studies where enzymes from biosynthesis have been used to construct complex molecules such as the vancomycin aglycone core structure. The complementarity between modern synthetic chemistry and enzyme catalyzed reactions make the pairing of the two highly powerful. As natural product biosynthesis is providing researchers with an expanded biocatalyst toolbox and protein engineering is significantly improving the properties and function of these biocatalysts, many of the key hurdles to robust chemo-enzymatic pathways are being overcome. This Special Issue of Molecules is designed to capture the highly interdisciplinary interplay between synthesis and biosynthesis in accessing complex molecules.
We welcome original articles as well as reviews of recent studies combining synthesis and biosynthesis, particularly focusing on chemo-enzymatic synthesis but also including enabling studies such as biomimetic total synthesis, new biocatalyst discovery, and in vitro biosynthesis.
Prof. Christopher N. Boddy
Dr. Graham Heberlig
Guest Editors
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Keywords
- Biosynthesis
- Chemoenzymatic
- Biocatalysis
- Tandem-catalysis
- Precursor directed biosynthesis
- Mutasynthesis
- Biomimetic synthesis
- Natural products
- Polyketides
- Non-ribosomal peptides
- Ribosomally synthesized and post-translationally modified peptides
- Terpenoids
- Alkaloids
- Carbohydrates
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