Chemical Control of Genome Editing
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Chemical Biology".
Deadline for manuscript submissions: closed (31 October 2019) | Viewed by 4726
Special Issue Editors
Interests: receptor-mediated delivery; liver regeneration; microRNA biogenesis; genome editing
Special Issues, Collections and Topics in MDPI journals
Interests: CRISPR/Cas- directed gene eding; small molecules; HDR, NHEJ; regulation of genome editing
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The breakthrough technology of gene editing, and in particular, CRISPR/Cas has revolutionized the potential for genomic modification in human cells. This exciting technology already plays an important role in drug discovery, agriculture and the nascent field of gene drives. The potential for clinical application is developing at a rapid rate, and a number of clinical trials are already in the making. The possibility for curing diseases appears to be just around the corner. Yet, unregulated activity of CRISPR/Cas, as well as the handful of other gene editing techniques can lead to unwanted and potentially serious outcomes. In this important and timely issue of Molecules, we will examine the use of small molecules to control the regulatory circuitry that surrounds gene editing in human cells. Topics of interest include small molecules that enhance nuclear delivery, those that tip the balance toward homology directed repair and away from nonhomologous end joining, potential approaches that act to modify the Cas nuclease family both directly and indirectly and molecules that act as anti-CRISPR agents for the overall control of chromosomal modification. Small molecules or strategies that reduce off-site mutagenesis or regulate the amount of indel formation surrounding the target site are also welcome and of great interest.
Dr. Clifford J. Steer
Dr. Eric B. Kmiec
Guest Editors
Manuscript Submission Information
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Keywords
- genome editing
- small molecules
- CRISPR/Cas
- nuclear delivery
- functional regulation
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