Chemical Processes in Degenerative Diseases
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Chemical Biology".
Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 4178
Special Issue Editor
Interests: cellular adaptation and metabolism; proteastasis; neuronal stress response; neuroprotection; aging
Special Issue Information
Dear Colleagues,
Aging and degenerative diseases are fundamentally characterized by an apparent increase in uncontrolled biochemical reactions. These spontaneous chemical processes comprise the undue aggregation and cross-linking of proteins as well as the opposite phenomenon: undue hydrolysis and fragmentation of essential macromolecular structures. Moreover, excessive oxidation frequently occurs in small molecules as well as proteins and other polymers to result in oxidative stress, although examples of uncontrolled reduction triggering cytotoxic cascades have also been described. Beyond these pairs of opposites, specific cases of isomerization, e.g., of amino acids, are notable markers of aging and degenerative disease. In many cases, however, it is yet uncertain whether disordering reactions indeed run faster during disease, or whether physiological repair processes have become slower.
The present Special Issue of Molecules entitled “Chemical Processes in Degenerative Diseases” is intended to highlight and summarize the current knowledge on these elementary chemical processes that are at the very heart of degenerative pathology. Common and uncommon chemical processes are equally suitable for this Special Issue. Analytical and interventional studies as well as review articles are welcome.
Prof. Dr. Parvana Hajieva
Guest Editor
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Keywords
- aging
- aggregation of macromolecules
- cross-linking
- hydrolysis
- isomerization
- fragmentation
- oxidation
- post-translational modification
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