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Recent Progress in Green Organic Synthesis
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Recent Progress in Green Organic Synthesis

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (28 February 2024) | Viewed by 6028

Special Issue Editor

Dr. Gheorghita Zbancioc

E-Mail Website1 Website2
Guest Editor
Chemistry Department, Alexandru Ioan Cuza University of Iasi, 700506 Iasi, Romania
Interests: azines; diazines; medicinal chemistry; anticancer; antituberculosis; microwave; ultrasounds; organic synthesis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Green organic synthesis aims to reduce pollution at its source by minimizing or eliminating the hazards of chemical feedstocks, reagents, solvents, and products. If a technology reduces or eliminates the hazardous chemicals used to clean up environmental contaminants, this technology would qualify as a green chemistry technology.

Green organic synthesis takes into account the following principles: preventing waste; maximizing atom economy; designing less hazardous chemical syntheses; designing safer chemicals and products (having little or no toxicity); using safer solvents and reaction conditions; increasing energy efficiency; using renewable rather than depletable feedstocks; avoidance of using blocking or protecting groups or any temporary modifications if possible; using catalysts, not stoichiometric reagents; designing chemicals and products to degrade after use so that they do not accumulate in the environment; analyzing in real time to prevent pollution; and minimizing the potential for accidents (explosions, fires, and releases to the environment).

Microwave or ultrasound assisted synthesis may be considered environmentally friendly in terms of higher yields, smaller amounts of solvent used, and an overall energy efficiency due to a substantial reduction in reaction times.

The aim of this Special Issue is to provide a platform to present the latest developments in green organic synthesis, focused on the synthesis of especially (but not only) microwave or ultrasound assisted synthesis.

Prof. Dr. Gheorghita Zbancioc
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • green organic synthesis
  • ultrasound
  • microwave
  • safer solvents, chemicals and products
  • preventing waste
  • renewable feedstocks
  • energy efficiency
  • environmentally friendly

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Published Papers (3 papers)

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Research

11 pages, 1193 KiB  
Article
Ionic Organic Solid 1,3-Bis(sulfomethyl)imidazoliumate as an Effective Metal-Free Catalyst for Sustainable Organic Syntheses
by Mario Martos, Angélica M. Guapacha and Isidro M. Pastor
Molecules 2023, 28(6), 2695; https://doi.org/10.3390/molecules28062695 - 16 Mar 2023
Viewed by 1684
Abstract
The 1,3-bis(sulfomethyl)imidazole (bsmim) was effectively prepared by a multicomponent reaction, employing aminomethanesulfonic acid, glyoxal, and formaldehyde. The catalytic activity of bsmim was tested in the synthesis of quinoline derivatives, by means of the Friedländer reaction, and in the allylic substitution of alcohols with [...] Read more.
The 1,3-bis(sulfomethyl)imidazole (bsmim) was effectively prepared by a multicomponent reaction, employing aminomethanesulfonic acid, glyoxal, and formaldehyde. The catalytic activity of bsmim was tested in the synthesis of quinoline derivatives, by means of the Friedländer reaction, and in the allylic substitution of alcohols with nitrogen-containing heterocycles. The performance of sulfo-imidazole derivative (bsmim) resulted in higher comparison with the carboxyimidazole analogs (bcmim and bcmimCl), under the same reaction conditions. This type of ionic organic solid allows the promotion of reactions in the absence of solvent and mild reaction conditions, which improves the sustainability of organic synthetic processes. Full article
(This article belongs to the Special Issue Recent Progress in Green Organic Synthesis)
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Scheme 1

13 pages, 2498 KiB  
Communication
Bis(pyridine)enaminone as a Precursor for the Synthesis of Bis(azoles) and Bis(azine) Utilizing Recent Economic Green Chemistry Technology: The Q-Tube System
by Khadijah M. Al-Zaydi, Tamer S. Saleh, Norah F. Alqahtani and Meaad S. Bagazi
Molecules 2023, 28(5), 2355; https://doi.org/10.3390/molecules28052355 - 3 Mar 2023
Cited by 2 | Viewed by 1784
Abstract
We reported herein efficient economic high-pressure synthesis procedures for the synthesis of bis(azoles) and bis(azines) by utilizing the bis(enaminone) intermediate. Bis(enaminone) reacted with hydrazine hydrate, hydroxylamine hydrochloride, guanidine hydrochloride, urea, thiourea, and malononitrile to form the desired bis azines and bis azoles. A [...] Read more.
We reported herein efficient economic high-pressure synthesis procedures for the synthesis of bis(azoles) and bis(azines) by utilizing the bis(enaminone) intermediate. Bis(enaminone) reacted with hydrazine hydrate, hydroxylamine hydrochloride, guanidine hydrochloride, urea, thiourea, and malononitrile to form the desired bis azines and bis azoles. A combination of elemental analyses and spectral data was used to confirm the structures of the products. Compared with conventional heating, the high-pressure Q-Tube method promotes reactions in a short period of time and provides high yields. Full article
(This article belongs to the Special Issue Recent Progress in Green Organic Synthesis)
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Figure 1

10 pages, 1020 KiB  
Article
Ultrasound-Assisted Synthesis of Fluorescent Azatetracyclic Derivatives: An Energy-Efficient Approach
by Gheorghita Zbancioc, Catalina-Ionica Ciobanu, Ionel I. Mangalagiu and Costel Moldoveanu
Molecules 2022, 27(10), 3180; https://doi.org/10.3390/molecules27103180 - 16 May 2022
Cited by 4 | Viewed by 1609
Abstract
We report here an energy-efficient and straight synthesis of two new classes of derivatized fluorescent azatetracycles under ultrasound (US) irradiation. A first class of azatetracyclic compounds was synthesized by heterogeneous catalytic bromination of the α-keto substituent attached to the pyrrole moiety of the [...] Read more.
We report here an energy-efficient and straight synthesis of two new classes of derivatized fluorescent azatetracycles under ultrasound (US) irradiation. A first class of azatetracyclic compounds was synthesized by heterogeneous catalytic bromination of the α-keto substituent attached to the pyrrole moiety of the tetracyclic cycloadducts, while for the second, one class was synthesized by nucleophilic substitution of the bromide with the azide group. Comparative with conventional thermal heating (TH) under US irradiation, both types of reactions occur with substantially higher yields, shortened reaction time (from days to hours), lesser energy consumed, easier workup of the reaction, and smaller amounts of solvent required (at least three to five-fold less compared to TH), which make these reactions to be considered as energy efficient. The derivatized azatetracycle are blue emitters with λmax of fluorescence around 430–445 nm. A certain influence of the azatetracycle substituents concerning absorption and fluorescent properties was observed. Compounds anchored with a bulky azide group have shown decreased fluorescence intensity compared with corresponding bromides. Full article
(This article belongs to the Special Issue Recent Progress in Green Organic Synthesis)
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