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Nanomaterials in Photothermal Therapy beyond 2020

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Nanochemistry".

Deadline for manuscript submissions: closed (15 August 2021) | Viewed by 3302

Special Issue Editors


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Guest Editor
Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Avda. Joan XXIII, 27-31, 08028 Barcelona, Spain
Interests: colloids; micelles; layer-by-layer; liposomes; magnetic particles; drug delivery; magnetic hyperthermia; magnetic photothermia
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Avda. Joan XXIII, 27-31, 08028 Barcelona, Spain
Interests: colloidal systems; liposomes; Langmuir–Blodgett films; membrane models; drug delivery; surfaces; magnetic nanoparticles; prussian blue nanoparticles; liposomes; magnetoliposomes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to introduce this Special issue of Molecules devoted to the research of nanomaterials aimed for photothermal therapy (PTT). PTT constitutes a promising young strategy for the treatments of several diseases, in particular cancer. PTT is based on the transformation of energy into heat. It encompasses two techniques—hyperthermia and thermal ablation. In the first case, a low or moderate temperature is applied for a long time, whereas in thermal ablation, the patient is subjected to high temperatures, usually around 50 °C for a few min of exposition. PTT requires the co-occurrence of at least a heat-responsive material, the so-called photothermal agents, and an energy source. Laser radiation is an appropriate source for being easily focused on a very specific damaged area without affecting the healthy environment. In particular, the laser of the NIR region (600–1350 nm) is appealing since it covers the well-known biological windows, where light is less absorbed and shows, hence, the deepest penetration in tissues. Much wider is the range of compound candidates to be considered as photothermal agents per se or in combination with other materials. From all these challenging approaches and in view of the promising and broad fields of research related to this subject, we encourage researchers already working in this field or who desire to start working in it to submit their original works for publication in this Special Issue.

Prof. Dr. Joan Estelrich
Assoc. Prof. Dr. Maria Antònia Busquets
Guest Editors

Manuscript Submission Information

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Keywords

  • Photothermal agents
  • Photothermal ablation
  • Photothermal energy conversion
  • Theranostic nanomedicine
  • Photothermal efficiency
  • NIR
  • Biological windows

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Published Papers (1 paper)

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Research

12 pages, 2158 KiB  
Article
Superparamagnetic Nanoparticles with Efficient Near-Infrared Photothermal Effect at the Second Biological Window
by Maria Antònia Busquets, Juan Marcos Fernández-Pradas, Pedro Serra and Joan Estelrich
Molecules 2020, 25(22), 5315; https://doi.org/10.3390/molecules25225315 - 14 Nov 2020
Cited by 8 | Viewed by 2724
Abstract
Superparamagnetic nanoparticles (iron oxide nanoparticles—IONs) are suitable for hyperthermia after irradiating with radiofrequency radiation. Concerning the suitability for laser ablation, IONs present a low molar absorption coefficient in the near-infrared region close to 800 nm. For this reason, they are combined with other [...] Read more.
Superparamagnetic nanoparticles (iron oxide nanoparticles—IONs) are suitable for hyperthermia after irradiating with radiofrequency radiation. Concerning the suitability for laser ablation, IONs present a low molar absorption coefficient in the near-infrared region close to 800 nm. For this reason, they are combined with other photothermal agents into a hybrid composite. Here, we show that IONs absorb and convert into heat the infrared radiation characteristic of the so-called second-biological window (1000–1350 nm) and, in consequence, they can be used for thermal ablation in such wavelengths. To the known excellent water solubility, colloidal stability and biocompatibility exhibited by IONs, an outstanding photothermal performance must be added. For instance, a temperature increase of 36 °C was obtained after irradiating at 8.7 W cm−2 for 10 min a suspension of IONs at iron concentration of 255 mg L−1. The photothermal conversion efficiency was ~72%. Furthermore, IONs showed high thermogenic stability during the whole process of heating/cooling. To sum up, while the use of IONs in the first bio-window (700–950 nm) presents some concerns, they appear to be good photothermal agents in the second biological window. Full article
(This article belongs to the Special Issue Nanomaterials in Photothermal Therapy beyond 2020)
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