Design and Synthesis of Novel Antiviral Agents
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Chemical Biology".
Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 3352
Special Issue Editors
Interests: organic chemistry; analytical chemistry; antivirals; nutraceuticals; food chemistry
Special Issues, Collections and Topics in MDPI journals
Interests: medicinal chemistry; synthetic organic chemistry; antiviral agents; drug design; protease inhibitors polymerase inhibitors; peptidomimetics; RNA virus; flavivirus; hepatitis C virus; coronavirus (SARS-CoV-2 and others)
Special Issues, Collections and Topics in MDPI journals
Interests: medicinal chemistry; drug design; synthetic organic chemistry; small molecules; structure–activity relationships; antivirals; anticancer agents; PROTAC
Interests: medicinal chemistry; antivirals; anticancer agents; organic synthesis; multicomponent reactions; green chemistry
Special Issue Information
Dear Colleagues,
Over the course of human civilization, viral infections have been part of human life and still represent one of the heaviest burdens for humans and society, with a huge devastating socioeconomic impact. Thanks to the development of several chemotherapeutics, the 20th century became famous for the eradication of some important diseases such as smallpox and polio, but nevertheless, for other viral infections-related diseases such Influenza, AIDS, SARS, and Ebola, just to name a few, the achievement of a suitable treatment is still a long way to go. Although we can protect ourselves thanks to behavioral prophylaxis and vaccination, vaccines remain unavailable for many viral pathogens, and thus, the identification and development of antiviral agents represent an unmet medical need. Indeed, the combination therapy of antiviral small molecules has provided a cure for hepatitis C virus (HCV) infection and likely eradication in the near future. Moreover, viruses replicate using highly different mechanisms, impairing the identification of broadly active antivirals. Indeed, each viral pathogen requires a dedicated investment of resources and time, but being caught unprepared can be really dramatic, as currently demonstrated by the global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pushed by this global crisis, the field has been involved in an unprecedented effort to enhance established antiviral strategies as well as develop innovative approaches for new classes of antiviral agents targeting different pathways, including viral and host factors and new antiviral modalities.
In this Special Issue on the “Design and Synthesis of Novel Antiviral Agents”, we are inviting the submission of original research articles, letters, and reviews from academic groups, not-for-profit organizations, or the industry working on the identification, synthesis, and evaluation of direct-acting antiviral or host-targeting agents that inhibit viral replication or pathogenesis.
Prof. Vincenzo Summa
Dr. Rolando Cannalire
Dr. Jenny Desantis
Dr. Sveva Pelliccia
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- antivirals
- viral infections
- broad-spectrum agents
- small molecule heterocycles
- synthetic strategy
- resistance emergence
- direct-acting antiviral
- host targeting antiviral
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