Role of lncRNAs in Brain Development and Disease
A special issue of Non-Coding RNA (ISSN 2311-553X). This special issue belongs to the section "Long Non-Coding RNA".
Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 20212
Special Issue Editors
Interests: epigenetics; gene expression; nuclear organisation; X chromosome inactivation and reactivation; spatial control of gene expression; long non-coding RNAs at single gene and genome-wide level
Interests: molecular biology; long non-coding RNAs; gene expression; neuronal differentiation
Special Issue Information
Dear Colleagues,
In recent years, genome-wide studies have highlighted the complexity of mammalian genomes, showing that only a small percentage of the genome codes for proteins, both in mice and humans. Most cell transcripts represent non-coding RNAs (ncRNAs), RNAs that do not code for proteins. ncRNAs are grouped into different classes and sub-classes according to their biogenesis, function, and structure. Among these, long ncRNAs (lncRNAs) are defined as RNA molecules that are longer than 200 nucleotides, lacking an open reading frame (ORF), and generally transcribed by RNA polymerase II and subjected to 5' capping, splicing, and polyadenylation.
RNAs play an active role in gene expression in many fundamental cellular processes, such as development, differentiation, proliferation, and cell metabolism. Recent research has shown that several lncRNAs are brain-specific, suggesting a key role in development and higher brain functions. Deregulation of this class of RNA has also been linked to neuropsychiatric disorders and neurodegenerative diseases.
For this Special Issue, we welcome the submission of reviews and original research articles on the topic of lncRNAs’ role in brain development and disease, with the aim of having a dedicated article collection focusing on lncRNA action and dysregulation in physiological and pathological processes.
Dr. Andrea Cerase
Dr. Vincenza Aliperti
Guest Editors
Manuscript Submission Information
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Keywords
- brain
- long non-coding RNA
- development
- neuronal disorders
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