Toxoplasmosis in Immunocompromised and Immunocompetent Host: Recent Updates About the Epidemiology, Diagnosis, Clinical Manifestations and Management

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Parasitic Pathogens".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 739

Special Issue Editor


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Guest Editor
Dr Jack S. Remington Laboratory for Specialty Diagnostics, Palo Alto Medical Foundation, Palo Alto, CA 94301, USA
Interests: new insights in pathogenesis; new evidence on the epidemiology of T. gondii strains and toxoplasma infections; novel diagnostics; empirical data on the clinical spectrum of disease; toxoplasmosis outcomes and effectiveness of preventive/therapeutic strategies; novel drugs; vaccines
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Special Issue Information

Dear Colleagues,

In this Special Issue for Pathogens, we would like to focus on recent updates in the research on the epidemiology, diagnosis, clinical manifestations and management of toxoplasmosis in immunocompromised and immunocompetent patients. We are interested in the atypical clinical presentations that toxoplasmosis can have in immunocompromised patients, including those who have undergone hematopoietic stem cell transplant and solid organ transplant, AIDS patients and patients on diverse immunosuppressive/immunomodulatory/biologic agents for diverse malignancies and/or autoimmune diseases, that should increase awareness among health care providers about toxoplasmosis. We would also like to welcome papers on unusual and/or severe clinical manifestations in immunocompetent patients. We want to address the changing epidemiology of toxoplasmosis in different settings, including outbreaks of toxoplasmosis in certain settings/communities and the role of novel diagnostics including molecular diagnostics/metagenomics cell-free DNA and point-of-care tests. We would like to gain insights into the diversity of treatment approaches, the challenges in accessing first line anti-toxoplasma medications and the safety issues with anti-toxoplasma treatment regimens. We encourage diverse types of eligible articles, including reviews, position papers, recommendations/guidelines, systematic reviews and meta-analyses, economic analyses, case reports, case series, cohort studies, case-control studies and clinical trials. The goal of this Special Issue is to bring attention to toxoplasmosis, a neglected infectious disease with high morbidity and mortality in some cases that is nevertheless preventable and treatable.

Dr. Despina G. Contopoulos-Ioannidis
Guest Editor

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Keywords

  • toxoplasmosis
  • immunocompromised
  • immunocompetent
  • diagnosis
  • treatment

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Published Papers (1 paper)

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6 pages, 541 KiB  
Brief Report
Increase in Congenital Toxoplasmosis During the COVID-19 Pandemic in the US
by Despina G. Contopoulos-Ioannidis, Valerie Bonetti and Jose G. Montoya
Pathogens 2024, 13(11), 937; https://doi.org/10.3390/pathogens13110937 - 28 Oct 2024
Viewed by 531
Abstract
During the COVID-19 pandemic, prenatal care services were disrupted. We analyzed the trajectory slopes of cases of congenital toxoplasmosis (CT) and acute toxoplasmosis during pregnancy from 2019 to 2022 (to reflect the cases during the pandemic years 2020–2022) vs. 2000 to 2019, using [...] Read more.
During the COVID-19 pandemic, prenatal care services were disrupted. We analyzed the trajectory slopes of cases of congenital toxoplasmosis (CT) and acute toxoplasmosis during pregnancy from 2019 to 2022 (to reflect the cases during the pandemic years 2020–2022) vs. 2000 to 2019, using data from the Remington Laboratory, the National Reference Center for Toxoplasmosis in the US. During the pandemic, there was a statistically significant upward trajectory in the yearly number of CT cases. Monitoring of this trend is needed. Full article
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