Chagas Disease: Celebrating the 115th Anniversary of the Discovery of Trypanosoma cruzi

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Parasitic Pathogens".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 1888

Special Issue Editor


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Guest Editor
MIVEGEC (IRD 224-CNRS 5290-UM1-UM2), Institute of Research for the Development, 34394 Montpellier CEDEX 5, France
Interests: genetics and evolution of infectious diseases
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Special Issue Information

Dear Colleagues,

It is my pleasure to introduce this Special Issue on Chagas disease, celebrating the 115th anniversary of the discovery of its causative agent. Our knowledge on the disease has made substantial progress in the last 20 years thanks to the impressive development of modern technologies ranging from genomics to megacomputing and artificial intelligence (AI). However, this should not occult the fact that the spread of Chagas disease is chiefly due to socioeconomical factors (poor habitats, sanitary education, access to health systems, etc.). This Special Issue will therefore keep a balance between advanced technology and socioecology. Considering the considerable role played by Latin American scientists, I am very happy to welcome the contribution of many of them in this Special Issue. My hope is that it will constitute a historical landmark in continuing research on this disease, which still poses a considerable public health challenge.

Dr. Michel Tibayrenc
Guest Editor

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Keywords

  • parasitology
  • genomics
  • drug development
  • socioeconomical factors
  • public health

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Published Papers (1 paper)

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Review

16 pages, 2016 KiB  
Review
The Functions of Cytokines in the Cardiac Immunopathogenesis of Chagas Disease
by Mariana Citlalli de Alba-Alvarado, Margarita Cabrera-Bravo, Edgar Zenteno, Paz María Salazar-Schetino and Martha Irene Bucio-Torres
Pathogens 2024, 13(10), 870; https://doi.org/10.3390/pathogens13100870 - 3 Oct 2024
Viewed by 1261
Abstract
Chagas disease is a complex zoonosis. Clinically, it presents in two distinct phases, acute and chronic. The ability of patients to respond to Trypanosoma cruzi infection depends on the balance between inflammatory and anti-inflammatory responses, in which cytokines play a key regulatory role. [...] Read more.
Chagas disease is a complex zoonosis. Clinically, it presents in two distinct phases, acute and chronic. The ability of patients to respond to Trypanosoma cruzi infection depends on the balance between inflammatory and anti-inflammatory responses, in which cytokines play a key regulatory role. In this review, we discuss the role of cytokines in regulating the host response and as mediators of cardiac injury by inducing profibrotic alterations. The importance of characterizing cytokine profiles as biomarkers of the evolution of cardiac damage in T.-cruzi-infected individuals is also emphasized. Full article
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