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Pathogens
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Exploring Natural Products as Antiparasitic Agents: Efficacy against Parasites of...
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Exploring Natural Products as Antiparasitic Agents: Efficacy against Parasites of Veterinary and Public Health Significance

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Parasitic Pathogens".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 2171

Special Issue Editors

Dr. Agustín Olmedo-Juárez

E-Mail Website
Guest Editor
Laboratory of Helminthology, National Centre for Disciplinary Research in Animal Health and Innocuity (CENID-SAI), National Institute for Research in Forestry, Agriculture and Livestock, INIFAP-SADER, Jiutepec 62550, Mexico
Interests: plant extracts; phenolic acids; gastointetinal nematodes; natural products
Dr. Elke Von Son-De Fernex

E-Mail Website
Guest Editor
Teaching, Research and Extension in Tropical Livestock Center, Faculty of Veterinary Medicine and Zootechnics, National Autonomous University of Mexico (CEIEGT-FMVZ-UNAM), Martínez de la Torre, Veracruz 93600, Mexico
Interests: Plant extract; secondary metabolites; phytochemicals; nematodes; biological control

Special Issue Information

Dear Colleagues, 

The increasing prevalence of anthelmintic resistance among the three major groups of parasites (helminths, protozoa, and arthropods) affecting domesticated animals (pets and livestock) represents a significant challenge to both public and veterinary health. Thus, the development of novel antiparasitic agents is crucial. In this context, natural products derived from plants, fungi, and marine organisms have emerged as a promising resource. 

We are excited to invite you to submit your work for the upcoming Special Issue called “Exploring Natural Products as Antiparasitic agents: Efficacy against Parasites of Public and Veterinary Health Significance” and thereby contribute to this topic with original research articles, reviews, and short communications. This Special Issue aims to showcase the latest advancements in the development of novel antiparasitic agents, thereby allowing access to up-to-date knowledge on the subject and guiding future research in this field.

The topics of interest include (but are not limited to) the following. 

Dr. Agustín Olmedo-Juárez
Dr. Elke Von Son-De Fernex
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plant extracts
  • phytochemicals
  • fungi
  • parasites
  • anthelmintics
  • secondary metabolites
  • natural compounds
  • ethnoveterinary

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Published Papers (2 papers)

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Research

11 pages, 270 KiB  
Article
Using an Aqueous Suspension of Duddingtonia flagrans Chlamydospores and a Hexane Extract of Artemisia cina as Sustainable Methods to Reduce the Fecal Egg Count and Larvae of Haemonchus contortus in the Feces of Periparturient Ewes
by Héctor Alejandro de la Crúz-Crúz, Rosa Isabel Higuera-Piedrahita, Alejandro Zamilpa, Yazmín Alcalá-Canto, Ana Yuridia Ocampo-Gutiérrez, Luis David Arango-de la Pava, María Eugenia López-Arellano, Daniel Hernandez-Patlan, Jorge Alfredo Cuéllar-Ordaz and Pedro Mendoza-de Gives
Pathogens 2025, 14(2), 105; https://doi.org/10.3390/pathogens14020105 - 21 Jan 2025
Viewed by 640
Abstract
This study evaluated the effectiveness of Duddingtonia flagrans chlamydospores and an Artemisia cina hexane extract in reducing Haemonchus contortus fecal egg counts and larvae in periparturient ewes. This study involved five groups of four ewes: a control group, an ivermectin group, an A. [...] Read more.
This study evaluated the effectiveness of Duddingtonia flagrans chlamydospores and an Artemisia cina hexane extract in reducing Haemonchus contortus fecal egg counts and larvae in periparturient ewes. This study involved five groups of four ewes: a control group, an ivermectin group, an A. cina oral extract group, a D. flagrans group, and a combined treatment group. Treatments began two weeks before delivery, with ivermectin administered 15 days before delivery. Fecal samples were collected every fifteen days to estimate parasite egg counts per gram of feces (EPG) and assess larvae reductions. The results showed very low EPG values for ivermectin and D. flagrans treatments (175 and 150, respectively). The control and combined treatment groups had EPG values rise to 3000 and 4100 by day 15. The EPG values for the A. cina group reached 850 and 533 in later samplings. Throughout the study, the D. flagrans and A. cina groups maintained low EPG values, with the highest recorded values being 50 and 0, respectively. All treatments significantly reduced the larvae in the fecal cultures: D. flagrans (97.4% reduction), ivermectin (91.4%), Artemisia cina (89.9%), and the combined treatment (84.3%). Full article
(This article belongs to the Special Issue Exploring Natural Products as Antiparasitic Agents: Efficacy against Parasites of Veterinary and Public Health Significance)
13 pages, 932 KiB  
Article
The Anthelmintic Activity of Nepeta racemosa Lam. Against Gastrointestinal Nematodes of Sheep: Rosmarinic Acid Quantification and In Silico Tubulin-Binding Studies
by Büşra Karpuz Ağören, Mahmut Sinan Erez, Esma Kozan, Aydın Dağyaran, Mevlüt Akdağ, Eduardo Sobarzo-Sánchez and Esra Küpeli Akkol
Pathogens 2025, 14(1), 77; https://doi.org/10.3390/pathogens14010077 - 15 Jan 2025
Viewed by 888
Abstract
Gastrointestinal nematodes (GINs) inflict significant economic losses on sheep and goat farming globally due to reduced productivity and the development of anthelmintic resistance. Sustainable control strategies are urgently needed including the exploration of medicinal plants as safer alternatives to chemical anthelmintics. This genus [...] Read more.
Gastrointestinal nematodes (GINs) inflict significant economic losses on sheep and goat farming globally due to reduced productivity and the development of anthelmintic resistance. Sustainable control strategies are urgently needed including the exploration of medicinal plants as safer alternatives to chemical anthelmintics. This genus of plants is used for anti-inflammatory, antioxidant, and antimicrobial activities. In this study, we aimed to evaluate the anthelmintic activities of Nepeta racemosa Lam. MeOH extract, n-hexane, dichloromethane (DCM), ethyl acetate (EtOAc), n-buthanol (n-BuOH) and aqueous (H2O) subextracts, and quantify rosmarinic acid in the active extract by the HPLC method, and perform in silico molecular docking studies of rosmarinic acid to examine its binding interactions with tubulin. The anthelmintic activity of the plant extracts on gastrointestinal nematode eggs and larvae (L3) of the sheep was assessed using in vitro test methods such as the egg hatch assay and larval motility assay, conducted over a 24 h period (1, 2, 3, 4, 6, 8, 24). All extracts exhibited 100% effectiveness in the egg hatch inhibition assay, regardless of concentration (50–1.5625 mg/mL). The EtOAc subextract shows the highest effectiveness at 79.66%, followed by the MeOH extract at 74.00%, water at 64.00%, n-hexane at 67.00%, and DCM at 61.00%, and the lowest effectiveness is observed with n-BuOH at 51.66% in the larval motility assay. The major compound of EtOAc extract, the most active extract of N. racemosa, was determined as rosmarinic acid and its amount in the extract was determined as 14.50 mg/100 mg dry extract. The amount of rosmarinic acid in the MeOH extract was found to be 0.21 mg/100 mg dry extract. n-Hexane, DCM, n-BuOH, and H2O extracts’ rosmarinic acid content was lower than the LOQ value. As tubulin plays an important role in the mechanism of anthelmintics, the major compound of the most active extract (NR-EtOAc) rosmarinic acid was docked onto the colchicine-binding site of the tubulin (5OV7) protein. Rosmarinic acid showed a similar activity spectrum to the anthelmintic drug albendazole. The discovery of low-cost and low-toxicity anthelmintic compounds is very important. Full article
(This article belongs to the Special Issue Exploring Natural Products as Antiparasitic Agents: Efficacy against Parasites of Veterinary and Public Health Significance)
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