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Pathogens
Special Issues
Omics Analyses of Pathogenic Microorganisms and Related Diseases
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Omics Analyses of Pathogenic Microorganisms and Related Diseases

A special issue of Pathogens (ISSN 2076-0817).

Deadline for manuscript submissions: 31 December 2024 | Viewed by 1267

Special Issue Editors

Dr. Fei Chen

E-Mail Website
Guest Editor
Beijing Institute of Genomics, Chinese Academy of Sciences (Chinese National Center for Bioinformation), Beijing, China
Interests: microbial genomics; metagenomics; single-cell/spatial omics; antimicrobial resistance; pathogen immune microenvironment; tuberculosis; mycobacterium tuberculosis; klebsiella pneumonia
Dr. Cuidan Li

E-Mail Website
Guest Editor
Beijing Institute of Genomics, Chinese Academy of Sciences (Chinese National Center for Bioinformation), Beijing, China
Interests: pathogenic microbial genomics and biosafety

Special Issue Information

Dear Colleagues,

We are inviting submissions for our Special Issue, “Omics Analyses of Pathogenic Microorganisms and Related Diseases”, in Pathogens.

Pathogenic microorganisms, including various bacteria, viruses, and other pathogens, are major causes of a wide range of human diseases, including infectious diseases and cancers. This Special Issue aims to publish cutting-edge research that employs various omics technologies—including but not limited to genomics, transcriptomics, proteomics, metabolomics, epigenomics, single-cell omics, and spatial omics—to explore the molecular mechanisms of pathogenicity, virulence, drug resistance, evolution, and transmission of these microorganisms.

We welcome submissions in various formats, including research articles, letters, and, reviews. Scientists working in the fields of microbiology, infectious diseases, immunology, and related disciplines are warmly invited to contribute their work to this special issue.

Dr. Fei Chen
Dr. Cuidan Li
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microbial genomics
  • infectious disease genomics
  • pathogen immune microenvironment
  • single-cell/spatial omics
  • antimicrobial resistance

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Published Papers (1 paper)

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Research

30 pages, 6073 KiB  
Article
Transcriptomic and Proteomic Insights into Host Immune Responses in Pediatric Severe Malarial Anemia: Dysregulation in HSP60-70-TLR2/4 Signaling and Altered Glutamine Metabolism
by Clinton O. Onyango, Samuel B. Anyona, Ivy Hurwitz, Evans Raballah, Sharely A. Wasena, Shamim W. Osata, Philip Seidenberg, Benjamin H. McMahon, Christophe G. Lambert, Kristan A. Schneider, Collins Ouma, Qiuying Cheng and Douglas J. Perkins
Pathogens 2024, 13(10), 867; https://doi.org/10.3390/pathogens13100867 - 3 Oct 2024
Viewed by 965
Abstract
Severe malarial anemia (SMA, Hb < 6.0 g/dL) is a leading cause of childhood morbidity and mortality in holoendemic Plasmodium falciparum transmission zones. This study explored the entire expressed human transcriptome in whole blood from 66 Kenyan children with non-SMA (Hb ≥ 6.0 [...] Read more.
Severe malarial anemia (SMA, Hb < 6.0 g/dL) is a leading cause of childhood morbidity and mortality in holoendemic Plasmodium falciparum transmission zones. This study explored the entire expressed human transcriptome in whole blood from 66 Kenyan children with non-SMA (Hb ≥ 6.0 g/dL, n = 41) and SMA (n = 25), focusing on host immune response networks. RNA-seq analysis revealed 6862 differentially expressed genes, with equally distributed up-and down-regulated genes, indicating a complex host immune response. Deconvolution analyses uncovered leukocytic immune profiles indicative of a diminished antigenic response, reduced immune priming, and polarization toward cellular repair in SMA. Weighted gene co-expression network analysis revealed that immune-regulated processes are central molecular distinctions between non-SMA and SMA. A top dysregulated immune response signaling network in SMA was the HSP60-HSP70-TLR2/4 signaling pathway, indicating altered pathogen recognition, innate immune activation, stress responses, and antigen recognition. Validation with high-throughput gene expression from a separate cohort of Kenyan children (n = 50) with varying severities of malarial anemia (n = 38 non-SMA and n = 12 SMA) confirmed the RNA-seq findings. Proteomic analyses in 35 children with matched transcript and protein abundance (n = 19 non-SMA and n = 16 SMA) confirmed dysregulation in the HSP60-HSP70-TLR2/4 signaling pathway. Additionally, glutamine transporter and glutamine synthetase genes were differentially expressed, indicating altered glutamine metabolism in SMA. This comprehensive analysis underscores complex immune dysregulation and novel pathogenic features in SMA. Full article
(This article belongs to the Special Issue Omics Analyses of Pathogenic Microorganisms and Related Diseases)
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