Therapeutic Agents for Neurological Disorders
A topical collection in Pharmaceuticals (ISSN 1424-8247). This collection belongs to the section "Pharmacology".
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Interests: neurodegenerative diseases; Alzheimer’s disease; dementia; cell biology; molecular biology; ageing; therapeutics
Special Issues, Collections and Topics in MDPI journals
Topical Collection Information
Dear Colleagues,
Neurological disorders are disabling conditions that encompass, but are not limited to, cerebrovascular diseases, epilepsy, dementias (Alzheimer’s, frontotemporal and others), multiple sclerosis, movement disorders (Parkinson’s, amyotrophic lateral sclerosis and others), brain tumors and neuroinfections, amongst other issues. Globally, neurological disorders are the leading cause of disability-adjusted life years (DALYs). The absolute number of deaths and DALYs from all neurological disorders combined has increased significantly in the last decade. These findings outline an impending epidemic that requires urgent attention. Treatments for neurological disorders are challenging, but numerous advancements have been made in identifying mechanisms and delineating the pathways underlying these diseases. Advances in technologies that garner information from the fields of bioinformatics and next-generation and whole-genome sequencing have added invaluable support in identifying "culprit" genes and proteins. Using this information, scientists and clinicians have ventured into areas previously deemed "fiction". From brain-controlled, non-invasive muscle stimulators that help paraplegics walk to the editing of the CEP290 gene in individuals with Leber congenital amaurosis 10 (LCA10), as well as a plethora of therapies in between, biomedicine has made giant leaps in just over two decades. This Topical Collection aims to draw together research from experts in the field that highlight therapeutic agents and strategies, helping to identify future directions that will lead to discoveries and therapies for neurological disorders.
Dr. Damian Holsinger
Collection Editor
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Keywords
- neurodegeneration
- brain injury
- spinal cord injury
- neurodevelopmental disorders
- nerve repair
- brain tumors
- neuromodulation
- neuroinflammation
