Pharmacotherapy for Schizophrenia: New Advances
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".
Deadline for manuscript submissions: 22 December 2024 | Viewed by 295
Special Issue Editors
Interests: drugs and schizophrenia; preclinical models of schizophrenia; drugs and novel drug candidates
2. Department of Medicinal Chemistry, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany
3. Department of Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany
Interests: Alzheimer's disease; schizophrenia; depression
Special Issue Information
Dear Colleagues,
Schizophrenia is a severely debilitating psychiatric disorder that still poses significant therapeutic challenges. Progress in pharmacotherapy for schizophrenia has been limited over the past four decades, but several novel therapeutic concepts (NTCs) and compounds are currently emerging. Those NTCs involve the modulation of synaptic strength or synaptic plasticity, the moderation of excessive excitatory or insufficient inhibitory activity, or enhancement of protection against oxidative stress. Improved dopaminergic or serotonergic modulation also still play important roles. Novel compounds include newly developed drugs but also repurposed medication, which may be applied and tested in humans off-label. With such developments, future pharmacotherapeutic strategies envisioned for schizophrenia become increasingly complex, as the potential need for early intervention, patient stratification, combined psycho-social and pharmacological therapy, and precision medicine approaches becomes even more necessary. Significant drivers of the current progress in treatments are new circuit neuroscience techniques in preclinical investigations (like optogenetics, chemogenetics, in vivo imaging and CRISPR/Cas9-mediated genetic modulation), identification and validation of translatable physiological and psychological biomarkers, as well as the use of re-purposable drugs in experimental clinical trials, amongst others.
This Special Issue “Pharmacotherapy in Schizophrenia” welcomes contributions of original research articles or review articles covering those aspects, to illustrate the scope, possibilities, and challenges of future pharmacological treatment of schizophrenia.
Prof. Dr. Dennis Kätzel
Dr. Holger Rosenbrock
Guest Editors
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Keywords
- schizophrenia
- psychosis
- pharmaco-resistance
- refractory symptoms
- cognitive symptoms
- negative symptoms
- aberrant salience
- drug repurposing
- target discovery
- drug development
- translatable biomarkers
- endophenotypes
- precision medicine
- patient stratification
- circuit neuroscience
- glutamate hypothesis
- dopamine hypothesis
- oxidative stress
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