Telomere Length and Cardiovascular Disease: A Precursor Marker and Therapeutic Target
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Biopharmaceuticals".
Deadline for manuscript submissions: closed (22 October 2024) | Viewed by 320
Special Issue Editors
Interests: clinical and molecular cardiology; interventional cardiology; heart valves
Interests: clinical and molecular cardiology; endothelial function; arterial stiffness
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Over the last two decades, the scientific society has been investigating the role of biomarkers in the early detection of atherosclerotic disease. However, even with access to the most advanced technology and most recently available secondary prevention therapies, the burden of recurrent events following acute coronary syndromes remains high, ranging from 10% to 20% in the first 12 months. Currently, the investigation of telomeres as a potential tool for the early detection of atherosclerotic disease seems to be a promising method. Telomeres are repetitive DNA sequences located at the extremities of chromosomes that maintain genetic stability. Telomere length (TL) has been associated with several human disorders and diseases while its attrition rate varies significantly in the population. Therapy targeting telomere length also changed the way that medicine uses the therapeutic arsenal in several conditions, including cardiovascular diseases.
In this Special Issue, we aim to investigating how TL shortening serves as a precursor marker and a potential therapeutic target in cardiovascular disorders, and explore the current and future treatment options based on TL, new advances in pharmacological uses and the relationship between telomere research/biomarker research and drugs. We invite researchers to contribute their expertise and insights in uncovering the multifaceted aspects of TL in cardiovascular health for this comprehensive exploration.
Dr. Marios Sagris
Prof. Dr. Dimitris Tousoulis
Guest Editors
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Keywords
- telomere length
- DNA
- chromosomes
- cardiovascular disease
- atherosclerosis
- coronary artery disease
- valvular disease
- heart failure
- arrhythmias
- peripheral artery disease
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