Structural Insights into Protein Kinases-Targeted Therapies: Overcoming Resistance and Advancing Precision Oncology
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 22 October 2025 | Viewed by 45
Special Issue Editor
2. Department of Chemistry, Southwestern College, Chula Vista, CA 91910, USA
Interests: ALK; machine learning; drug design; drug resistance; computational modeling; non-coding RNAs
Special Issue Information
Dear Colleagues,
This special issue will focus on the structural basis of Protein Kinase inhibitor resistance, a major challenge in cancer therapy. It will explore the intricate relationship between Protein Kinases, inhibitor binding, and the emergence of resistance mechanisms, paving the way for more effective targeted therapies and personalized treatment strategies.
This special issue will be a valuable resource for researchers, clinicians, drug developers, and other stakeholders involved in the fight against cancer. We welcome colleagues in the field to join our collection. The research contents of this special issue include but are not limited to the followings:
- Structural Biology of Protein Kinases: Delving into the molecular architecture of Protein Kinases, including their catalytic domains, activation mechanisms, and interactions with inhibitors.
- Protein Kinases Inhibitor Resistance Mechanisms: Investigating the molecular basis of resistance to Protein Kinases inhibitors, encompassing mutations, conformational changes, and alternative signaling pathways.
- Computational Modeling and Drug Design: Utilizing computational methods, such as molecular docking, molecular dynamics simulations, and structure-based drug design, to predict and overcome drug resistance.
- Preclinical and Clinical Studies: Presenting preclinical and clinical data on the efficacy and resistance profiles of TK inhibitors, including novel drug candidates.
- Precision Oncology Strategies: Discussing the implications of understanding Protein Kinases resistance for personalized medicine, patient selection, and treatment optimization.
Dr. David Hecht
Guest Editor
Manuscript Submission Information
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Keywords
- protein kinases inhibitor resistance
- structural biology of of protein kinases
- computational modeling
- drug design
- preclinical and clinical studies
- precision oncology
- ALK resistance for personalized medicine
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