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Pharmaceutics
Special Issues
Nanoparticle-Mediated Diagnostics and Drug Delivery Therapy
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Nanoparticle-Mediated Diagnostics and Drug Delivery Therapy

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (24 August 2024) | Viewed by 4131

Special Issue Editors

Dr. Olga V. Dement'eva

E-Mail Website
Guest Editor
Laboratory of Surface Phenomena in Polymer Systems, Frumkin Institute of Physical Chemistry and Electrochemistry of Russian Academy of Sciences, Leninskiy Prosp. 31, Building 4, 119071 Moscow, Russia
Interests: nanoparticles synthesis; drug delivery; tumor theranostics; nanoparticles assembly; nanocomposites
Dr. Ivan N. Senchikhin

E-Mail Website
Guest Editor
Laboratory of Physical Chemistry of Colloidal Systems, Frumkin Institute of Physical Chemistry and Electrochemistry of Russian Academy of Sciences, Leninskiy Prosp. 31, Building 4, 119071 Moscow, Russia
Interests: nanoparticles synthesis; polymers; nanomaterials; composites; antibacterial activity
Dr. Andrey V. Sybachin

E-Mail Website
Guest Editor
Chemistry Department, Lomonosov Moscow State University, Leninskie Gory 1-3, 119991 Moscow, Russia
Interests: polyelectrolytes; liposomes; interfacial complexes; drug delivery; nanocontainers; micelles; biocides
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Increasing the treatment efficiency of various dangerous diseases is among the most urgent tasks of modern medicine. The primary ways to solve the issue are to develop methods for the early diagnosis of diseases and to the performance of minimally invasive therapy (including by means of targeted delivery and controlled release of drugs). Such delivery can significantly reduce the risk of side effects and, as a result, increase the patient's quality of life.

The use of different nanoparticles as diagnostic tools or drug carriers is of significant interest from both scientific and practical points of view, as the distribution of such nanocarriers in the body can be controlled by varying their size and/or surface chemistry. In addition, they can serve not only in diagnosis or transport, but also as therapeutic agents, acting as sensitizers of one or another external influence (radiation, laser, ultrasonic, etc.). As a result, it becomes possible to combine different types of therapy.

This Special Issue aims to bring together reviews and experimental works reflecting the main trends, challenges and latest advances in the creation and practical usage of nanoparticles that are capable of serving as diagnostic and drug delivery tools.

Dr. Olga V. Dement'eva
Dr. Ivan N. Senchikhin
Dr. Andrey V. Sybachin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials for diseases theranostics
  • nanomaterials for multimodal therapy
  • nanomaterials for diagnostics
  • stimuli responsive nanocarriers
  • biodegradable nanocarriers
  • the routes of drug nanocarriers’ administration
  • active and passive targeting of nanocarriers
  • nanocarriers biodistribution
  • toxicity of nanocarriers
  • delivery of hydrophobic drugs
  • microemulsions as drug delivery systems
  • drug encapsulation methods
  • drug release models

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Published Papers (2 papers)

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Research

17 pages, 3465 KiB  
Article
In Vitro and In Vivo Synergetic Radiotherapy with Gold Nanoparticles and Docetaxel for Pancreatic Cancer
by Abdulaziz Alhussan, Nolan Jackson, Norman Chow, Ermias Gete, Nicole Wretham, Nancy Dos Santos, Wayne Beckham, Cheryl Duzenli and Devika B. Chithrani
Pharmaceutics 2024, 16(6), 713; https://doi.org/10.3390/pharmaceutics16060713 - 26 May 2024
Cited by 1 | Viewed by 1407
Abstract
This research underscores the potential of combining nanotechnology with conventional therapies in cancer treatment, particularly for challenging cases like pancreatic cancer. We aimed to enhance pancreatic cancer treatment by investigating the synergistic effects of gold nanoparticles (GNPs) and docetaxel (DTX) as potential radiosensitizers [...] Read more.
This research underscores the potential of combining nanotechnology with conventional therapies in cancer treatment, particularly for challenging cases like pancreatic cancer. We aimed to enhance pancreatic cancer treatment by investigating the synergistic effects of gold nanoparticles (GNPs) and docetaxel (DTX) as potential radiosensitizers in radiotherapy (RT) both in vitro and in vivo, utilizing a MIA PaCa-2 monoculture spheroid model and NRG mice subcutaneously implanted with MIA PaCa-2 cells, respectively. Spheroids were treated with GNPs (7.5 μg/mL), DTX (100 nM), and 2 Gy of RT using a 6 MV linear accelerator. In parallel, mice received treatments of GNPs (2 mg/kg), DTX (6 mg/kg), and 5 Gy of RT (6 MV linear accelerator). In vitro results showed that though RT and DTX reduced spheroid size and increased DNA DSBs, the triple combination of DTX/RT/GNPs led to a significant 48% (p = 0.05) decrease in spheroid size and a 45% (p = 0.05) increase in DNA DSBs. In vivo results showed a 20% (p = 0.05) reduction in tumor growth 20 days post-treatment with (GNPs/RT/DTX) and an increase in mice median survival. The triple combination exhibited a synergistic effect, enhancing anticancer efficacy beyond individual treatments, and thus could be employed to improve radiotherapy and potentially reduce adverse effects. Full article
(This article belongs to the Special Issue Nanoparticle-Mediated Diagnostics and Drug Delivery Therapy)
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18 pages, 5683 KiB  
Article
Formation Kinetics and Antimicrobial Activity of Silver Nanoparticle Dispersions Based on N-Reacetylated Oligochitosan Solutions for Biomedical Applications
by Ekaterina K. Urodkova, Ol’ga Ya. Uryupina, Vladimir E. Tikhonov, Natalia E. Grammatikova, Anastasia V. Bol’shakova, Anna A. Sinelshchikova, Alexandra I. Zvyagina, Dmitry N. Khmelenin, Elena S. Zhavoronok and Ivan N. Senchikhin
Pharmaceutics 2023, 15(12), 2690; https://doi.org/10.3390/pharmaceutics15122690 - 28 Nov 2023
Viewed by 1925
Abstract
The paper presents the results of the synthesis, a detailed kinetics study, and an investigation of the biological activity of silver nanoparticles (AgNPs) in aqueous solutions of N-reacetylated oligochitosan hydrochloride. UV–visible spectrophotometry and dynamic light scattering were employed to control silver ion reduction. [...] Read more.
The paper presents the results of the synthesis, a detailed kinetics study, and an investigation of the biological activity of silver nanoparticles (AgNPs) in aqueous solutions of N-reacetylated oligochitosan hydrochloride. UV–visible spectrophotometry and dynamic light scattering were employed to control silver ion reduction. The process was observed to follow a pseudo-first-order law. Transmission and scanning electron microscopy demonstrated that AgNPs ranging in size from 10 to 25 nm formed aggregates measuring 60 to 90 nm, with the aggregate surface coated by a 2–4 nm chitosan shell. X-ray microanalysis and powder X-ray diffractometry were used to study the phase composition, identifying two crystalline phases, nanocrystalline silver and AgCl, present in the dispersions. The antibacterial effect was assessed using the serial dilution method for dispersions with varying degrees of Ag+ conversion. Nanodispersions exhibited significant activity against Escherichia coli, Pseudomonas aeruginosa, Bacillus cereus, and Staphylococcus aureus. Interestingly, the activity did not appear to be heavily influenced by the presence of the AgCl phase or the concentration of Ag+ ions. These synthesized dispersions hold promise for the development of materials tailored for biomedical applications. Full article
(This article belongs to the Special Issue Nanoparticle-Mediated Diagnostics and Drug Delivery Therapy)
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