Carbohydrate-Based Carriers for Drug Delivery, 2nd Edition

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 20 March 2025 | Viewed by 1107

Special Issue Editors


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Guest Editor
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy of Iași, 16 Universitaty Street, 700115 Iași, Romania
Interests: drug delivery; anti-inflammatory and analgesic effects; cyclodextrin inclusion complexes; ibuprofen derivatives; chemical synthesis; ionic liquids; polymers
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E-Mail Website
Guest Editor
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy of Iași, 16 Universitaty Street, 700115 Iași, Romania
Interests: organic synthesis; chitosan microparticles and nanoparticles; antioxidant activity; diabetes mellitus type 2; drug delivery systems; drug loading; release profile
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy of Iași, 16 Universitaty Street, 700115 Iași, Romania
Interests: anti-inflammatory potential; organic synthesis; nanogels; liposomes; nanocarriers; drug delivery systems
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy of Iași, 16 Universitaty Street, 700115 Iași, Romania
Interests: organic synthesis; drug delivery systems (liposomes, niosomes, chitosan nanoparticles, nanofiber, nanofibers, films, sponges); molecular docking; structure-based drug design strategies; antioxidant activity; anti-inflammatory activity; diabetes mellitus type 2
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Carbohydrates, or saccharides, are among the most common molecules found in nature and have biological and structural features that allow for their use in drug delivery systems as carriers. The main classes of these molecules include monosaccharides, oligosaccharides and polisaccharides, which have shown great potential for overcoming the limitations of drugs and navigating biological barriers to achieve targeted delivery. Chitosan, cyclodextrin, alginate, gellan, xanthan gum, cellulose, dextran, pullulan, etc., are some of the most well-known carbohydrate carriers in drug delivery. By protecting the structural integrity of the drug and proving hydrophilic properties, these carriers can modulate undesirable biological properties in drugs as well as their solubility and release profile.

Carbohydrates can improve drug delivery due to their ability to selectively bind to protein receptors, thus increasing drug targeting. They also have the advantages of nontoxicity, biodegradability, good biocompatibility and increased encapsulation stability.

In recent years, carbohydrate-based drug delivery systems have been developed and improved, with their use being of great interest to researchers for the treatment of inflammation, cancer, infections, chronic wounds, diabetes mellitus and other diseases.

This Special Issue will focus on current advances in carbohydrate-based carriers and their applications in drug delivery.

Dr. Ioana Mirela Vasincu
Dr. Florentina Lupascu
Dr. Maria Apotrosoaei
Prof. Dr. Lenuta Profire
Guest Editors

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Keywords

  • nanomaterials
  • drug delivery
  • release profile
  • polisaccharides
  • oligosaccharides
  • inclusion complexes
  • targeted therapy

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Published Papers (1 paper)

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Review

42 pages, 3161 KiB  
Review
Cationic Cyclodextrin-Based Carriers for Drug and Nucleic Acid Delivery
by Adila Nazli, Milo Malanga, Tamás Sohajda and Szabolcs Béni
Pharmaceutics 2025, 17(1), 81; https://doi.org/10.3390/pharmaceutics17010081 - 9 Jan 2025
Viewed by 846
Abstract
Cyclodextrins can serve as carriers for various payloads, utilizing their capacity to form unique host–guest inclusion complexes within their cavity and their versatile surface functionalization. Recently, cationic cyclodextrins have gained considerable attention, as they can improve drug permeability across negatively charged cell membranes [...] Read more.
Cyclodextrins can serve as carriers for various payloads, utilizing their capacity to form unique host–guest inclusion complexes within their cavity and their versatile surface functionalization. Recently, cationic cyclodextrins have gained considerable attention, as they can improve drug permeability across negatively charged cell membranes and efficiently condense negatively charged nucleic acid due to electrostatic interactions. This review focuses on state-of-the-art and recent advances in the construction of cationic cyclodextrin-based delivery systems. First, we identified different cationic moieties that are commonly employed in the design of cyclodextrins with enhanced complexation ability. Subsequently, a wide range of cationic cyclodextrin-based drug delivery systems were analyzed with emphasis on chemistry, drug release profiles, and therapeutic outcomes. The evaluation of the delivery platforms was also based on the four major types of drugs, such as anticancer, anti-inflammatory, antibacterial, and antidiabetic agents. The delivery systems for nucleic acids were also summarized while focusing on their condensation ability, transfection efficiency, and biocompatibility in comparison to commercially available vectors such as PEI 25 kDa and lipofectamine 2000. Furthermore, we highlighted the potential of cationic cyclodextrins in constructing multimodal delivery systems for the simultaneous encapsulation of both drugs and nucleic acids. Finally, the challenges and limitations associated with cationic cyclodextrin setups were discussed. Full article
(This article belongs to the Special Issue Carbohydrate-Based Carriers for Drug Delivery, 2nd Edition)
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