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Pharmaceutics
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Advances in the Development of Cutting-Edge Drug Delivery Systems for...
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Advances in the Development of Cutting-Edge Drug Delivery Systems for the Effective Treatment of Chronic Skin Wounds, 2nd Edition

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (20 June 2024) | Viewed by 4844

Special Issue Editors

Dr. Monica Boffito

E-Mail Website
Guest Editor
Department of Mechanical and Aerospace Engineering, Politecnico di Torino, 10129 Torino, Italy
Interests: hydrogels; physical and chemical hydrogels; drug delivery; tissue engineering; polymer synthesis; polymeric scaffolds
Special Issues, Collections and Topics in MDPI journals
Dr. Rossella Laurano

E-Mail Website
Guest Editor
Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy
Interests: biomaterial design; polyurethane synthesis; bioprinting; wound healing; drug delivery systems; multi-stimuli-responsive polymers; bioink design; cell culture; tissue modeling; inflammation modelling; hydrogels
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Hard-to-close wounds represent a huge burden on both society and healthcare systems, and their impact is expected to progressively grow due to the aging population and increasing incidence of obesity. To tackle this critical issue, a great variety of wound dressings have been developed that aim to locally release therapeutic agents, promptly address infections, and provide a proper wound environment to enhance tissue healing. Advancements in biomaterial design, diagnostic imaging, and material processing techniques have significantly supported the research on smart and innovative platforms. However, the ideal wound dressing still does not exist.

Therefore, this Special Issue aims at critically discussing the state of the art of wound dressings and highlighting future directions for the development of advanced systems to treat chronic skin wounds. We welcome the submission of original research articles and short communications, as well as reviews, mini-reviews, and systematic review articles. Special attention will be devoted to works dealing with the design of innovative drug delivery carriers (e.g., nanoparticles, hydrogels, membranes, scaffolds), smart patches, wound-responsive systems, drug-releasing bioinks, antimicrobial materials, and antibiotic-free treatments.

Dr. Monica Boffito
Dr. Rossella Laurano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • wound healing
  • hard-to-close skin wounds
  • biofilm
  • infected wounds
  • drug delivery systems
  • controlled drug release
  • stimuli-responsive hydrogels
  • biomaterials
  • antimicrobial materials
  • 3D bioprinted wound dressings
  • nanofibrous membranes
  • personalized wound dressings
  • tissue engineering
  • antibiotic-free treatments
  • nanoparticles

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Related Special Issue

Published Papers (2 papers)

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Review

31 pages, 2372 KiB  
Review
Translational Challenges in Drug Therapy and Delivery Systems for Treating Chronic Lower Extremity Wounds
by Danny Aljamal, Priya S. Iyengar and Tammy T. Nguyen
Pharmaceutics 2024, 16(6), 750; https://doi.org/10.3390/pharmaceutics16060750 - 2 Jun 2024
Cited by 1 | Viewed by 1128
Abstract
Despite several promising preclinical studies performed over the past two decades, there remains a paucity of market-approved drugs to treat chronic lower extremity wounds in humans. This translational gap challenges our understanding of human chronic lower extremity wounds and the design of wound [...] Read more.
Despite several promising preclinical studies performed over the past two decades, there remains a paucity of market-approved drugs to treat chronic lower extremity wounds in humans. This translational gap challenges our understanding of human chronic lower extremity wounds and the design of wound treatments. Current targeted drug treatments and delivery systems for lower extremity wounds rely heavily on preclinical animal models meant to mimic human chronic wounds. However, there are several key differences between animal preclinical wound models and the human chronic wound microenvironment, which can impact the design of targeted drug treatments and delivery systems. To explore these differences, this review delves into recent new drug technologies and delivery systems designed to address the chronic wound microenvironment. It also highlights preclinical models used to test drug treatments specific for the wound microenvironments of lower extremity diabetic, venous, ischemic, and burn wounds. We further discuss key differences between preclinical wound models and human chronic wounds that may impact successful translational drug treatment design. Full article
(This article belongs to the Special Issue Advances in the Development of Cutting-Edge Drug Delivery Systems for the Effective Treatment of Chronic Skin Wounds, 2nd Edition)
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27 pages, 2197 KiB  
Review
Photodynamic Therapy, Probiotics, Acetic Acid, and Essential Oil in the Treatment of Chronic Wounds Infected with Pseudomonas aeruginosa
by Jaeson D. Chin, Lei Zhao, Trenton G. Mayberry, Braydon C. Cowan, Mark R. Wakefield and Yujiang Fang
Pharmaceutics 2023, 15(6), 1721; https://doi.org/10.3390/pharmaceutics15061721 - 13 Jun 2023
Cited by 4 | Viewed by 2935
Abstract
As a prevalent medical problem that burdens millions of patients across the world, chronic wounds pose a challenge to the healthcare system. These wounds, often existing as a comorbidity, are vulnerable to infections. Consequently, infections hinder the healing process and complicate clinical management [...] Read more.
As a prevalent medical problem that burdens millions of patients across the world, chronic wounds pose a challenge to the healthcare system. These wounds, often existing as a comorbidity, are vulnerable to infections. Consequently, infections hinder the healing process and complicate clinical management and treatment. While antibiotic drugs remain a popular treatment for infected chronic wounds, the recent rise of antibiotic-resistant strains has hastened the need for alternative treatments. Future impacts of chronic wounds are likely to increase with aging populations and growing obesity rates. With the need for more effective novel treatments, promising research into various wound therapies has seen an increased demand. This review summarizes photodynamic therapy, probiotics, acetic acid, and essential oil studies as developing antibiotic-free treatments for chronic wounds infected with Pseudomonas aeruginosa. Clinicians may find this review informative by gaining a better understanding of the state of current research into various antibiotic-free treatments. Furthermore. this review provides clinical significance, as clinicians may seek to implement photodynamic therapy, probiotics, acetic acid, or essential oils into their own practice. Full article
(This article belongs to the Special Issue Advances in the Development of Cutting-Edge Drug Delivery Systems for the Effective Treatment of Chronic Skin Wounds, 2nd Edition)
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