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Pharmaceutics
Special Issues
Natural Products and Extracts Important for Skin Health and Diseases
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Natural Products and Extracts Important for Skin Health and Diseases

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".

Deadline for manuscript submissions: 10 April 2025 | Viewed by 2743

Special Issue Editors

Prof. Dr. Sławomir Wilczyński

E-Mail Website
Guest Editor
Department of Basic Biomedical Science, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Kasztanowa 3, 41-200 Sosnowiec, Poland
Interests: pharmacy; topical drug delivery; image analysis and processing; thermography; hyperspectral imaging; biomedical engineering; bioengineering
Special Issues, Collections and Topics in MDPI journals
Dr. Monika Michalak

E-Mail Website
Guest Editor
Collegium Medicum, Jan Kochanowski University, IX WiekówKielc 19, 35-317 Kielce, Poland
Interests: skin; plant extracts; secondary metabolites; essential oils; plant oils; phytochemistry; pharmacological properties of bioactive compounds

Special Issue Information

Dear Colleagues,

The skin is an organ which provides contact with the environment and protects the human body from pathogens, physical, mechanical, and chemical factors. There is growing interest in searching for novel, low-cost, highly effective, and safe compounds and products that can enhance and promote skin health. Natural products, due to their multidirectional bioactive compounds, are important as protective and active ingredients. They can protect the epidermis, the outer layer of the human skin formed by keratinocytes, which is the first line of defense against various harmful factors, i.e., pollution, ROS, UV, and ionizing radiation. They can also strengthen the skin’s hydrolipidic barrier, prevent transepidermal water loss, maintain the balance of the skin microbiota, modulate the skin’s immune system, as well as support the function of fibroblasts. Moreover, natural raw materials exhibit many biological effects, e.g., antimicrobial, anti-inflammatory, antimutagenic, anticarcinogenic, immunomodulatory, antioxidant, photoprotective, antityrosinase, and antiaging. Therefore, they can have great potential to cure different kinds of skin problems, including pigmentation disorders, inflammatory diseases (e.g., acne, rosacea, atopic dermatitis, psoriasis, and erythema), cutaneous vascular lesions, tumors, trauma (blows, cuts, or burn injuries to the skin), and viral, bacterial, fungal, and parasitic infections.

This Special Issue is dedicated to original research and reviews articles focusing on natural products and extracts important for proper functioning and the protection and curing of disease in the skin. Articles discussing the current state of the art in the field of molecules derived from natural products for cosmetic and pharmaceutic applications, as well as their mechanism of action and therapeutic indications for the treatment of skin disorders, are also welcome.

Prof. Dr. Sławomir Wilczyński
Dr. Monika Michalak
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skin health
  • skin cell protection
  • skin barrier functionality
  • skin microbiota
  • raw materials of plant/ animal/ and mineral origin
  • natural-based products
  • bioactive compounds
  • biological activities
  • pharmacological effects
  • topical formulations
  • skin diseases and treatment
  • supplementation
  • skin permeation
  • mechanism of action

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Published Papers (2 papers)

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Research

16 pages, 1666 KiB  
Article
Development and Characterization of Film-Forming Solution Loaded with Syzygium cumini (L.) Skeels for Topical Application in Post-Surgical Therapies
by Rosinéia Aparecida Vilela Cebrian, Mariana Dalmagro, Mariana Moraes Pinc, Guilherme Donadel, Larissa Aparecida Engel, Reinaldo Aparecido Bariccatti, Rafael Menck de Almeida, Kelen Menezes Flores Rossi de Aguiar, Emerson Luiz Botelho Lourenço and Jaqueline Hoscheid
Pharmaceutics 2024, 16(10), 1294; https://doi.org/10.3390/pharmaceutics16101294 - 4 Oct 2024
Viewed by 741
Abstract
Background/Objectives: Considering the antioxidant and antimicrobial properties attributed to compounds in Syzygium cumini extract, this research aimed to advance postoperative therapeutic innovations. Specifically, the study assessed the physicochemical properties of a film-forming solution (FFS) incorporated with S. cumini, evaluating its therapeutic potential [...] Read more.
Background/Objectives: Considering the antioxidant and antimicrobial properties attributed to compounds in Syzygium cumini extract, this research aimed to advance postoperative therapeutic innovations. Specifically, the study assessed the physicochemical properties of a film-forming solution (FFS) incorporated with S. cumini, evaluating its therapeutic potential for postoperative applications. Methods: The S. cumini extract was meticulously characterized to determine its chemical composition, with particular emphasis on the concentration of phenolic compounds. Antioxidant and antimicrobial assays were conducted to assess the extract’s efficacy in these domains. Following this, an FFS containing S. cumini was formulated and evaluated comprehensively for skin adhesion, mechanical and barrier properties, and thermal behavior. Results: The antioxidant and antimicrobial activities of the S. cumini extract demonstrated promising results, indicating its potential utility as an adjunct in postoperative care. The developed FFS exhibited favorable physicochemical properties for topical application, including adequate skin adhesion and appropriate pH levels. Moreover, chemical and thermal analyses confirmed the formulation’s stability and the retention of the extract’s beneficial properties. Conclusions: Overall, the findings suggest that the S. cumini-loaded FFS holds significant potential as a valuable therapeutic tool for post-surgical management. Full article
(This article belongs to the Special Issue Natural Products and Extracts Important for Skin Health and Diseases)
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14 pages, 8574 KiB  
Article
Therapeutic Effect of Liquiritin Carbomer Gel on Topical Glucocorticoid-Induced Skin Inflammation in Mice
by Yun Zhang, Sijia Li, Yanfang Huang, Congjing Song, Weiqiang Chen and Yiling Yang
Pharmaceutics 2024, 16(8), 1001; https://doi.org/10.3390/pharmaceutics16081001 - 28 Jul 2024
Viewed by 1249
Abstract
Glucocorticoids are often used and highly effective anti-inflammatory medications, but prolonged topical application may alter the epidermis’ normal structure and function, potentially resulting in a number of adverse effects. Topical glucocorticoid-induced skin inflammation is a dangerous condition that develops after topical glucocorticoid use. [...] Read more.
Glucocorticoids are often used and highly effective anti-inflammatory medications, but prolonged topical application may alter the epidermis’ normal structure and function, potentially resulting in a number of adverse effects. Topical glucocorticoid-induced skin inflammation is a dangerous condition that develops after topical glucocorticoid use. The patients become dependent on the medication and, even after the medication is stopped, the dermatitis symptoms recur, severely impairing their quality of life. Thus, the need to aggressively confront Topical glucocorticoid-induced skin inflammation is critical. Prior research has demonstrated that topical administration of licorice’s flavonoid component liquiritin stimulates epidermal proliferation, which in turn enhances the creation of collagen and the healing of wounds. Therefore, the purpose of this work was to determine if topical use of liquiritin carbomer gel can treat glucocorticoid-induced changes in mice skin epidermal function, and the mechanisms involved. The findings demonstrated that, in the mice model of topical glucocorticoid-induced skin inflammation, liquiritin carbomer gel aided in the restoration of skin barrier function. These outcomes may have been caused by enhanced expression of the proteins Aquaporin 3, Keratin 10, and Claudin-1, as well as the restoration of epidermal hyaluronan content. In the meantime, liquiritin carbomer gel dramatically decreased the expression of TNF-α, IL-1β, IL-6, IFN-γ, and IgE in mice, according to ELISA tests. Furthermore, topical treatment of liquiritin carbomer gel boosted the expression of superoxide dismutase, catalase, and decreased malondialdehyde expression, potentially counteracting the detrimental effects of glucocorticoids on the epidermis. In summary, these findings imply that topical liquiritin carbomer gel can treat glucocorticoid-induced skin damage through various mechanisms of action. Full article
(This article belongs to the Special Issue Natural Products and Extracts Important for Skin Health and Diseases)
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