Contribution of Dendrimers and Other Dendritic Polymers in Medical Nanotechnology

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 1455

Special Issue Editors


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Guest Editor
Institute of Nanoscience and Nanotechnology, NCSR “Demokritos”, 15310 Athens, Greece
Interests: dendritic polymers; xerogels; water purification; liquid crystals; metal nanoparticle catalysts; antimicrobial coatings
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Guest Editor
Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Interests: wastewater treatment; carbon nanotubes; nanotechnology; porous materials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The concept of mimicking nature’s dendritic patterns through radial polymerization has afforded such a diversity of derivatives that their recognition as a fourth class of polymers is imperative. Research on dendritic polymers is characterized by its interdisciplinary nature, with both current and prospected applications involving most of the natural and medical sciences. The latter benefit from these polymers’ exceptional properties, unique architecture and similarity to biomolecules. The intramolecular cavities and intermolecular associations range from ions and small molecules to large biological entities. External groups are susceptible to functionalization and, in parallel, provide high local concentrations of active groups. In harmony with the trend of nanotechnology-empowered implementations, solutions to major health challenges have been discovered. These may adopt different conformations of nano-species: complexes, membranes, spheres, matrices, scaffolds, tubes, fibers and particles. Composites are produced in combination with organic and inorganic materials such as metals, ceramics and allotropic carbon forms. Drug delivery, tissue engineering, contrast agents, sensors and gene transfection are indicative examples. As life expectancy continues to increase, the need for novel, improved therapeutic and diagnostic tools is becoming increasingly critical. This Special Issue is dedicated to all the efforts of contemporary scientists working in the field to address sanitary needs and aims to present the broad spectrum of future prospects of this research.

Dr. Michael Arkas
Dr. Dimitrios Giannakoudakis
Guest Editors

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Keywords

  • drug delivery
  • tissue engineering
  • regenerative medicine
  • contrast agents
  • bioimaging
  • biosensors
  • gene transfection
  • antimicrobial agents
  • hyperbranched polymers
  • bioinspired
  • biomimetic
  • matrices
  • scaffolds

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Published Papers (1 paper)

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Research

15 pages, 9953 KiB  
Article
PAMAM-Calix-Dendrimers: Third Generation Synthesis and Impact of Generation and Macrocyclic Core Conformation on Hemotoxicity and Calf Thymus DNA Binding
by Olga Mostovaya, Igor Shiabiev, Daniil Ovchinnikov, Dmitry Pysin, Timur Mukhametzyanov, Alesia Stanavaya, Viktar Abashkin, Dzmitry Shcharbin, Arthur Khannanov, Marianna Kutyreva, Mingwu Shen, Xiangyang Shi, Pavel Padnya and Ivan Stoikov
Pharmaceutics 2024, 16(11), 1379; https://doi.org/10.3390/pharmaceutics16111379 - 27 Oct 2024
Viewed by 707
Abstract
Background/Objectives: Current promising treatments for many diseases are based on the use of therapeutic nucleic acids, including DNA. However, the list of nanocarriers is limited due to their low biocompatibility, high cost, and toxicity. The design of synthetic building blocks for creating [...] Read more.
Background/Objectives: Current promising treatments for many diseases are based on the use of therapeutic nucleic acids, including DNA. However, the list of nanocarriers is limited due to their low biocompatibility, high cost, and toxicity. The design of synthetic building blocks for creating universal delivery systems for genetic material is an unsolved problem. In this work, we propose PAMAM dendrimers with rigid thiacalixarene core in various conformations, i.e., PAMAM-calix-dendrimers, as a platform for a supramolecular universal constructor for nanomedicine. Results: Third generation PAMAM dendrimers with a macrocyclic core in three conformations (cone, partial cone, and 1,3-alternate) were synthesized for the first time. The obtained dendrimers were capable of binding and compacting calf thymus DNA, whereby the binding efficiency improved with increasing generation, while the influence of the macrocyclic core was reduced. A dramatic effect of the macrocyclic core conformation on the hemolytic activity of PAMAM-calix-dendrimers was observed. Specifically, a notable reduction in hemotoxicity was associated with a decrease in compound amphiphilicity. Conclusions: We hope the results will help reduce financial and labor costs in developing new drug delivery systems based on dendrimers. Full article
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