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Pharmaceutics
Special Issues
Nanoformulations for Local Treatment of Cancer, Infections and Wounds
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Nanoformulations for Local Treatment of Cancer, Infections and Wounds

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 2999

Special Issue Editors

Prof. Dr. Orlando David Henrique dos Santos

E-Mail Website
Guest Editor
Department of Pharmacy, Federal University of Ouro Preto, Ouro Preto 35400-000, Brazil
Interests: nanotechnology; nanoparticles; nanoformulation
Special Issues, Collections and Topics in MDPI journals
Dr. Glenda Nicioli da Silva

E-Mail Website
Guest Editor
Department of Pharmacy, Federal University of Ouro Preto, Ouro Preto 35400-000, Brazil
Interests: RNA; cancer; cardiovascular diseases; natural products
Dr. Tatiane Roquete Amparo

E-Mail Website
Guest Editor
Department of Pharmacy, Federal University of Ouro Preto, Ouro Preto 35400-000, Brazil
Interests: natural products; nanotechnology; anti-inflammatory; antibacterial activity

Special Issue Information

Dear Colleagues,

The local application of drugs offers several advantages over systemic use, including a greater drug concentration at the site of action and reduced off-target tissue toxicity. For instance, high efficacy has been reported for bladder cancer treatment via intravesical administration, brain, lung, and ovarian tumor treatment via intra-tumoral implantation, and skin infection treatment via topical application. Nevertheless, there are challenges, such as penetration into the epithelium and the drug remaining at the site of action. Nanotechnology can assist in overcoming these challenges. Nanoformulations can promote penetration, increase residence time at the application site, and also allow the sustained release of drugs, thus avoiding the need for multiple administrations. Therefore, this Special Issue aims to highlight the most recent advances in nanoformulations for the local treatment of cancer, infections, or inflammatory diseases. Given the significance of the research in this field, I extend an invitation to you to submit your original research articles or reviews to this Special Issue. Together, we can contribute to the search for more effective alternatives for treating diseases with high prevalence and/or mortality.

Research areas may include (but are not limited to) the following: nanoparticles, gels, and/or nanoemulsion for the topical treatment of infections and inflammatory diseases, nanoformulations for the intravesical treatment of bladder cancer, and nano-sized drug delivery systems for intratumoral administration including drugs of natural or synthetic origin.

We look forward to receiving your contributions.

Prof. Dr. Orlando David Henrique dos Santos
Dr. Glenda Nicioli da Silva
Dr. Tatiane Roquete Amparo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoformulation
  • local application
  • cancer
  • infections
  • wound healing
  • nanotechnology
  • topical application
  • intravesical application
  • intratumoral administration
  • gel
  • nanoemulsion
  • nanoparticle

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Published Papers (3 papers)

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Research

33 pages, 9655 KiB  
Article
Development of Technology for the Synthesis of Nanocrystalline Cerium Oxide Under Production Conditions with the Best Regenerative Activity and Biocompatibility for Further Creation of Wound-Healing Agents
by Ekaterina V. Silina, Victor A. Stupin, Natalia E. Manturova, Elena L. Chuvilina, Akhmedali A. Gasanov, Anna A. Ostrovskaya, Olga I. Andreeva, Natalia Y. Tabachkova, Maxim A. Abakumov, Aleksey A. Nikitin, Alexey A. Kryukov, Svetlana A. Dodonova, Aleksey V. Kochura and Maksim A. Pugachevskii
Pharmaceutics 2024, 16(11), 1365; https://doi.org/10.3390/pharmaceutics16111365 - 25 Oct 2024
Viewed by 638
Abstract
Background/Objectives: The issue of effective wound healing remains highly relevant. The objective of the study is to develop an optimal method for the synthesis of nanosized cerium oxide powder obtained via the thermal decomposition of cerium carbonate precipitated from aqueous nitrate solution for [...] Read more.
Background/Objectives: The issue of effective wound healing remains highly relevant. The objective of the study is to develop an optimal method for the synthesis of nanosized cerium oxide powder obtained via the thermal decomposition of cerium carbonate precipitated from aqueous nitrate solution for the technical creation of new drugs in production conditions; the select modification of synthesis under different conditions based on the evaluation of the physicochemical characteristics of the obtained material and its biological activity, and an evaluation of the broad-spectrum effect on cells involved in the regeneration of skin structure as well as antimicrobial properties. Methods: Several modes of the industrial synthesis of cerium dioxide nanoparticles (NPs) were carried out. The synthesis stages and the chemical and physical parameters of the obtained NPs were described using transmission electron microscopy (TEM), X-ray diffraction, Raman spectroscopy, and mass spectrometry. The cell cultures of human fibroblasts and keratinocytes were cultured with different concentrations of different nanoceria variations, and the cytotoxicity and the metabolic and proliferative activity were investigated. An MTT test and cell counting were performed. The antimicrobial activity of CeO2 variations at a concentration of 0.1–0.0001 M against Pseudomonas aeruginosa was studied. Results: The purity of the synthesized nanoceria powders in all the batches was >99.99%. According to TEM data, the size of the NPs varied from 1 nm to 70 nm under different conditions and methodologies. The most optimal technology for the synthesis of the nanoceria with the maximum biological effect was selected. A method for obtaining the most bioactive NPs of optimal size (up to 10 nm) was proposed. The repeatability of the results of the proposed method of nanoceria synthesis in terms of particle size was confirmed. It was proven that the more structural defects on the surface of the CeO2 crystal lattice, the higher the efficiency of the NPs due to oxygen vacancies. The strain provided the best redox activity and antioxidant properties of the nanoceria, which was demonstrated by better regenerative potential on various cell lines. The beneficial effect of synthesized nanoceria on the proliferative and metabolic activity of the cell lines involved in skin regeneration (human fibroblasts, human keratinocytes) was demonstrated. The antimicrobial effect of synthesized nanoceria on the culture of the most-resistant-to-modern-antibiotics microorganism Pseudomonas aeruginosa was confirmed. The optimal concentrations of the nanoceria to achieve the maximum biological effect were determined (10−3 M). Conclusions: It was possible to develop a method for the industrial synthesis of nanoceria, which can be used to produce drugs and medical devices containing CeO2 NPs. Full article
(This article belongs to the Special Issue Nanoformulations for Local Treatment of Cancer, Infections and Wounds)
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13 pages, 3605 KiB  
Article
Clindamycin-Loaded Polyhydroxyalkanoate Nanoparticles for the Treatment of Methicillin-Resistant Staphylococcus aureus-Infected Wounds
by Muneeb Ullah, Juho Lee, Nurhasni Hasan, Md. Lukman Hakim, Dongmin Kwak, Hyunwoo Kim, Eunhye Lee, Jeesoo Ahn, Bora Mun, Eun Hee Lee, Yunjin Jung and Jin-Wook Yoo
Pharmaceutics 2024, 16(10), 1315; https://doi.org/10.3390/pharmaceutics16101315 - 10 Oct 2024
Viewed by 854
Abstract
Background/Objectives: Owing to the growing resistance of methicillin-resistant Staphylococcus aureus (MRSA) to conventional antibiotics, the development of innovative therapeutic strategies for the treatment of MRSA-infected cutaneous wounds poses a significant challenge. Methods: Here, by using polyhydroxyalkanoates (PHA), emerging biodegradable and biocompatible polymers naturally [...] Read more.
Background/Objectives: Owing to the growing resistance of methicillin-resistant Staphylococcus aureus (MRSA) to conventional antibiotics, the development of innovative therapeutic strategies for the treatment of MRSA-infected cutaneous wounds poses a significant challenge. Methods: Here, by using polyhydroxyalkanoates (PHA), emerging biodegradable and biocompatible polymers naturally produced by various microorganisms, we developed clindamycin-loaded PHA nanoparticles (Cly-PHA NPs) as a novel approach for the treatment of MRSA-infected cutaneous wounds. Results: Cly-PHA NPs were characterized in terms of mean particle size (216.2 ± 38.9 nm), polydispersity index (0.093 ± 0.03), zeta potential (11.3 ± 0.5 mV), and drug loading (6.76 ± 0.19%). Owing to the sustained release of clindamycin over 2 days provided by the PHA, Cly-PHA NPs exhibited potent antibacterial effects against MRSA. Furthermore, Cly-PHA NPs significantly facilitated wound healing in a mouse model of MRSA-infected full-thickness wounds by effectively eradicating MRSA from the wound bed. Conclusions: Therefore, our results suggest that Cly-PHA NPs offer a promising approach for combating MRSA infections and accelerating cutaneous wound healing. Full article
(This article belongs to the Special Issue Nanoformulations for Local Treatment of Cancer, Infections and Wounds)
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Graphical abstract

17 pages, 4899 KiB  
Article
Inhibition of Angiogenesis and Effect on Inflammatory Bowel Disease of Ginsenoside Rg3-Loaded Thermosensitive Hydrogel
by Yiqiong Xie, Ying Ma, Lu Xu, Hongwen Liu, Weihong Ge, Baojuan Wu, Hongjue Duan, Hongmei Zhang, Yuping Fu, Hang Xu, Yuxiang Sun, Zhou Han and Yun Zhu
Pharmaceutics 2024, 16(10), 1243; https://doi.org/10.3390/pharmaceutics16101243 - 25 Sep 2024
Viewed by 1063
Abstract
Background: Inflammatory bowel disease (IBD), characterized by chronic inflammation of the digestive tract, involves angiogenesis as a key pathogenic mechanism. Ginsenoside Rg3, derived from the traditional Chinese herb ginseng, is recognized for its anti-angiogenic properties but is limited by low oral bioavailability. [...] Read more.
Background: Inflammatory bowel disease (IBD), characterized by chronic inflammation of the digestive tract, involves angiogenesis as a key pathogenic mechanism. Ginsenoside Rg3, derived from the traditional Chinese herb ginseng, is recognized for its anti-angiogenic properties but is limited by low oral bioavailability. This necessitates the development of an alternative delivery system to improve its therapeutic effectiveness. Methods: Pluronic F-127 (F127) and Pluronic F-68 (F68) were used to construct Rg3-loaded thermosensitive hydrogel Gel-Rg3. Meanwhile, a series of physicochemical properties were determined. Then the safety and pharmacological activity of Gel-Rg3 were evaluated in vitro and in vivo using human umbilical vein endothelial cells (HUVECs) and colitis mouse model, in order to initially validate the potential of Gel-Rg3 for the treatment of IBD. Results: We engineered a rectally administrable, thermosensitive Gel-Rg3 hydrogel using F127 and F68, which forms at body temperature, enhancing Rg3’s intestinal retention and slowly releasing the drug. In vitro, Gel-Rg3 demonstrated superior anti-angiogenic activity by inhibiting HUVEC proliferation, migration, and tube formation. It also proved safer and better suited for IBD’s delicate intestinal environment than unformulated Rg3. In vivo assessments confirmed increased intestinal adhesion and anti-angiogenic efficacy. Conclusions: The Gel-Rg3 hydrogel shows promise for IBD therapy by effectively inhibiting angiogenesis via rectal delivery, overcoming Rg3’s bioavailability limitations with improved safety and efficacy. This study provides new inspiration and data support for the design of treatment strategies for IBD. Full article
(This article belongs to the Special Issue Nanoformulations for Local Treatment of Cancer, Infections and Wounds)
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