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Pharmaceutics
Special Issues
Bioadhesive Systems for Topical Application
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Bioadhesive Systems for Topical Application

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".

Deadline for manuscript submissions: closed (31 October 2020) | Viewed by 31774

Special Issue Editors

Dr. Luana Perioli

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Guest Editor
Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, Italy
Interests: pharmaceutical technology; drud delivery systems
Special Issues, Collections and Topics in MDPI journals
Dr. Cinzia Pagano

E-Mail Website
Guest Editor
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, Via del Liceo, 1, 06123 Perugia, Italy
Interests: pharmaceutical technology; drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Topical therapy is often preferred to a systemic one because it allows treating the pathological site, avoiding healthy tissues. The success of a local therapy derives from the use of a suitable active ingredient adequately formulated. Many formulations show a limited low residence time responsible for partial and incomplete treatment. This is responsible for delayed healing times and risks of recurrence in the case of infections. This problem is particularly emphasized in the case of ulcers of both skin and mucosa.

The development of new technologies that are able to enhance the residence time of topically applied drugs is necessary for the treatment of local pathologies.

In this context, bioadhesive delivery systems are strategic and useful tools for the local treatment of skin and mucosal diseases.

Prof. Luana Perioli
Dr. Cinzia Pagano
Guest Editors

Manuscript Submission Information

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Keywords

  • bioadhesion
  • skin
  • mucosa
  • ulcers
  • infections
  • inflammation
  • antibiofilm
  • local therapy

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Related Special Issue

Published Papers (5 papers)

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Research

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19 pages, 4942 KiB  
Article
Development and Characterization of Xanthan Gum and Alginate Based Bioadhesive Film for Pycnogenol Topical Use in Wound Treatment
by Cinzia Pagano, Debora Puglia, Francesca Luzi, Alessandro Di Michele, Stefania Scuota, Sara Primavilla, Maria Rachele Ceccarini, Tommaso Beccari, César Antonio Viseras Iborra, Daniele Ramella, Maurizio Ricci and Luana Perioli
Pharmaceutics 2021, 13(3), 324; https://doi.org/10.3390/pharmaceutics13030324 - 3 Mar 2021
Cited by 29 | Viewed by 3394
Abstract
Pycnogenol (PYC) is a concentrate of phenolic compounds derived from French maritime pine; its biological activity as antioxidant, anti-inflammatory and antibacterial suggests its use in the treatment of open wounds. A bioadhesive film, loaded with PYC, was prepared by casting, starting with a [...] Read more.
Pycnogenol (PYC) is a concentrate of phenolic compounds derived from French maritime pine; its biological activity as antioxidant, anti-inflammatory and antibacterial suggests its use in the treatment of open wounds. A bioadhesive film, loaded with PYC, was prepared by casting, starting with a combination of two biopolymer acqueous solutions: xanthan gum (1% wt/wt) and sodium alginate (1.5% wt/wt), in a 2.5/7.5 (wt/wt) ratio. In both solutions, glycerol (10% wt/wt) was added as plasticizing agent. The film resulted in an adhesive capable to absorb a simulated wound fluid (~ 65% wt/wt within 1 h), therefore suitable for exuding wounds. The mechanical characterization showed that the film is deformable (elastic modulus E = 3.070 ± 0.044 MPa), suggesting adaptability to any type of surface and resistance to mechanical solicitations. PYC is released within 24 h by a sustained mechanism, achieving a maximum concentration of ~ 0.2 mg/mL, that is safe for keratinocytes, as shown by cytotoxicity studies. A concentration of 0.015 mg/mL is reached in the first 5 min after application, at which point PYC stimulates keratinocyte growth. These preliminary results suggest the use of PYC in formulations designed for topical use. Full article
(This article belongs to the Special Issue Bioadhesive Systems for Topical Application)
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18 pages, 3965 KiB  
Article
Polymer/Iron-Based Layered Double Hydroxides as Multifunctional Wound Dressings
by Mariana Pires Figueiredo, Ana Borrego-Sánchez, Fátima García-Villén, Dalila Miele, Silvia Rossi, Giuseppina Sandri, César Viseras and Vera Regina Leopoldo Constantino
Pharmaceutics 2020, 12(11), 1130; https://doi.org/10.3390/pharmaceutics12111130 - 23 Nov 2020
Cited by 14 | Viewed by 3903
Abstract
This work presents the development of multifunctional therapeutic membranes based on a high-performance block copolymer scaffold formed by polyether (PE) and polyamide (PA) units (known as PEBA) and layered double hydroxide (LDH) biomaterials, with the aim to study their uses as wound dressings. [...] Read more.
This work presents the development of multifunctional therapeutic membranes based on a high-performance block copolymer scaffold formed by polyether (PE) and polyamide (PA) units (known as PEBA) and layered double hydroxide (LDH) biomaterials, with the aim to study their uses as wound dressings. Two LDH layer compositions were employed containing Mg2+ or Zn2+, Fe3+ and Al3+ cations, intercalated with chloride anions, abbreviated as Mg-Cl or Zn-Cl, or intercalated with naproxenate (NAP) anions, abbreviated as Mg-NAP or Zn-NAP. Membranes were structurally and physically characterized, and the in vitro drug release kinetics and cytotoxicity assessed. PEBA-loading NaNAP salt particles were also prepared for comparison. Intercalated NAP anions improved LDH–polymer interaction, resulting in membranes with greater mechanical performance compared to the polymer only or to the membranes containing the Cl-LDHs. Drug release (in saline solution) was sustained for at least 8 h for all samples and release kinetics could be modulated: a slower, an intermediate and a faster NAP release were observed from membranes containing Zn-NAP, NaNAP and Mg-NAP particles, respectively. In general, cell viability was higher in the presence of Mg-LDH and the membranes presented improved performance in comparison with the powdered samples. PEBA containing Mg-NAP sample stood out among all membranes in all the evaluated aspects, thus being considered a great candidate for application as multifunctional therapeutic dressings. Full article
(This article belongs to the Special Issue Bioadhesive Systems for Topical Application)
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14 pages, 4327 KiB  
Article
Nitric Oxide-Releasing S-Nitrosoglutathione-Conjugated Poly(Lactic-Co-Glycolic Acid) Nanoparticles for the Treatment of MRSA-Infected Cutaneous Wounds
by Juho Lee, Dongmin Kwak, Hyunwoo Kim, Jihyun Kim, Shwe Phyu Hlaing, Nurhasni Hasan, Jiafu Cao and Jin-Wook Yoo
Pharmaceutics 2020, 12(7), 618; https://doi.org/10.3390/pharmaceutics12070618 - 2 Jul 2020
Cited by 47 | Viewed by 5511
Abstract
S-nitrosoglutathione (GSNO) has emerged as a potent agent for the treatment of infected cutaneous wounds. However, fabrication of GSNO-containing nanoparticles has been challenging due to its high hydrophilicity and degradability. The present study aimed to fabricate nanoparticles using newly synthesized GSNO-conjugated poly(lactic- [...] Read more.
S-nitrosoglutathione (GSNO) has emerged as a potent agent for the treatment of infected cutaneous wounds. However, fabrication of GSNO-containing nanoparticles has been challenging due to its high hydrophilicity and degradability. The present study aimed to fabricate nanoparticles using newly synthesized GSNO-conjugated poly(lactic-co-glycolic acid) (PLGA) (GSNO-PLGA; GPNPs). Since hydrophilic GSNO was covalently bound to hydrophobic PLGA, loss of GSNO during the nanoparticle fabrication process was minimized, resulting in sufficient loading efficiency (2.32% of GSNO, 0.07 μmol/mg of NO). Real-time NO release analysis revealed biphasic NO release by GPNPs, including initial burst release within 3 min and continuous controlled release for up to 11.27 h, due to the differential degradation rates of the –SNO groups located at the surface and inside of GPNPs. Since GPNPs could deliver NO more efficiently than GSNO in response to increased interaction with bacteria, the former showed enhanced antibacterial effects against methicillin-resistant Staphylococcus aureus (MRSA) at the same equivalent concentrations of NO. Finally, the facilitating effects of GPNPs on infected wound healing were demonstrated in MRSA-challenged full-thickness wound mouse model. Collectively, the results suggested GPNPs as an ideal nanoparticle formulation for the treatment of MRSA-infected cutaneous wounds. Full article
(This article belongs to the Special Issue Bioadhesive Systems for Topical Application)
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21 pages, 3532 KiB  
Article
Bioprinting and Preliminary Testing of Highly Reproducible Novel Bioink for Potential Skin Regeneration
by Forough Hafezi, Susan Shorter, Atabak Ghanizadeh Tabriz, Andrew Hurt, Victoria Elmes, Joshua Boateng and Dennis Douroumis
Pharmaceutics 2020, 12(6), 550; https://doi.org/10.3390/pharmaceutics12060550 - 13 Jun 2020
Cited by 56 | Viewed by 6435
Abstract
Three-dimensional (3D) bioprinting is considered as a novel approach in biofabricating cell-laden constructs that could potentially be used to promote skin regeneration following injury. In this study, a novel crosslinked chitosan (CH)–genipin (GE) bioink laden with keratinocyte and human dermal fibroblast cells was [...] Read more.
Three-dimensional (3D) bioprinting is considered as a novel approach in biofabricating cell-laden constructs that could potentially be used to promote skin regeneration following injury. In this study, a novel crosslinked chitosan (CH)–genipin (GE) bioink laden with keratinocyte and human dermal fibroblast cells was developed and printed successfully using an extruder-based bioprinter. By altering the composition and degree of CH–GE crosslinking, bioink printability was further assessed and compared with a commercial bioink. Rheological analysis showed that the viscosity of the optimised bioink was in a suitable range that facilitated reproducible and reliable printing by applying low pressures ranging from 20–40 kPa. The application of low printing pressures proved vital for viability of cells loaded within the bioinks. Further characterisation using MTT assay showed that cells were still viable within the printed construct at 93% despite the crosslinking, processing and after subjecting to physiological conditions for seven days. The morphological study of the printed cells showed that they were mobile within the bioink. Furthermore, the multi-layered 3D printed constructs demonstrated excellent self-supportive structures in a consistent manner. Full article
(This article belongs to the Special Issue Bioadhesive Systems for Topical Application)
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Review

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21 pages, 2584 KiB  
Review
Mucoadhesive Electrospun Fibre-Based Technologies for Oral Medicine
by Jake G. Edmans, Katharina H. Clitherow, Craig Murdoch, Paul V. Hatton, Sebastian G. Spain and Helen E. Colley
Pharmaceutics 2020, 12(6), 504; https://doi.org/10.3390/pharmaceutics12060504 - 2 Jun 2020
Cited by 38 | Viewed by 11916
Abstract
Oral disease greatly affects quality of life, as the mouth is required for a wide range of activities including speech, food and liquid consumption. Treatment of oral disease is greatly limited by the dose forms that are currently available, which suffer from short [...] Read more.
Oral disease greatly affects quality of life, as the mouth is required for a wide range of activities including speech, food and liquid consumption. Treatment of oral disease is greatly limited by the dose forms that are currently available, which suffer from short contact times, poor site specificity, and sensitivity to mechanical stimulation. Mucoadhesive devices prepared using electrospinning offer the potential to address these challenges by allowing unidirectional site-specific drug delivery through intimate contact with the mucosa and with high surface areas to facilitate drug release. This review will discuss the range of electrospun mucoadhesive devices that have recently been reported to address oral inflammatory diseases, pain relief, and infections, as well as new treatments that are likely to be enabled by this technology in the future. Full article
(This article belongs to the Special Issue Bioadhesive Systems for Topical Application)
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