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Pharmaceutics
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Advances in Polymeric Drug Delivery Systems, 2nd Edition
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Advances in Polymeric Drug Delivery Systems, 2nd Edition

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 10 January 2025 | Viewed by 2877

Special Issue Editors

Dr. Joanna Rydz

E-Mail Website
Guest Editor
Centre of Polymer and Carbon Materials, Polish Academy of Sciences, 41-819 Zabrze, Poland
Interests: biobased or/and biodegradable polymers; polyesters; (bio)degradation; prediction study
Special Issues, Collections and Topics in MDPI journals
Dr. Barbara Zawidlak-Węgrzyńska

E-Mail Website
Guest Editor
Department of Chemistry, Faculty of Medicine in Zabrze, Academy of Silesia, 40-555 Katowice, Poland
Interests: biomaterials; biocompatibility of polymer systems; (bio)degradable and synthetic polymers in medical applications; degradation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Research into the design, characterization, fabrication, and development of drug delivery systems used in pharmaceuticals based on natural and synthetic polymers has achieved tremendous growth over the past two decades. Efficient drug delivery systems are designed to improve the pharmacokinetics and pharmacodynamics of any therapy. Their goal is to enable the drug to be delivered to the right place, at the right time, and in the right amount. Drug delivery systems employ strategies such as controlled release, targeted delivery, or improving the solubility and stability of a drug in such a way so as to provide increased drug efficacy. The next step in effective drug delivery is to select a drug delivery system that can achieve the desired results.

The purpose of this Special Issue is to provide a contemporary overview of the latest developments in drug delivery systems, particularly breakthroughs and advances in the synthesis, fabrication, characterization, and applications of innovative polymeric biomaterials in drug delivery. The recently increasingly used (bio)degradable polymers are also noteworthy, as well as design and fabrication techniques, such as additive manufacturing, offering innovative possibilities for the design and development of systems with complex geometry, and programmed controlled release profiles. Original research articles, case reports, letters, and short communications covering aspects of the current trends in the development of such systems will be welcome.

Dr. Joanna Rydz
Dr. Barbara Zawidlak-Węgrzyńska
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug delivery
  • controlled release
  • biopolymers
  • nanopolymers
  • nanoparticles
  • (bio)degradable polymers
  • synthetic polymers
  • 3D printing
  • personalized medicine

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Related Special Issue

Published Papers (2 papers)

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Research

19 pages, 4663 KiB  
Article
Enrofloxacin Pharmaceutical Formulations through the Polymer-Free Electrospinning of β-Cyclodextrin–oligolactide Derivatives
by Diana-Andreea Blaj, Cătălina Anișoara Peptu, Maricel Danu, Valeria Harabagiu, Cristian Peptu, Alexandra Bujor, Lăcrămioara Ochiuz and Cristina Gabriela Tuchiluș
Pharmaceutics 2024, 16(7), 903; https://doi.org/10.3390/pharmaceutics16070903 - 5 Jul 2024
Viewed by 839
Abstract
Enrofloxacin (ENR), a member of the fluoroquinolone class of antibiotics, is widely used in veterinary medicine to treat bacterial infections. Like many antibiotics, ENR has limited water solubility and low bioavailability. To address these challenges, drug formulations using solid dispersions, nanosuspensions, surfactants, cocrystal/salt [...] Read more.
Enrofloxacin (ENR), a member of the fluoroquinolone class of antibiotics, is widely used in veterinary medicine to treat bacterial infections. Like many antibiotics, ENR has limited water solubility and low bioavailability. To address these challenges, drug formulations using solid dispersions, nanosuspensions, surfactants, cocrystal/salt formation, and inclusion complexes with cyclodextrins may be employed. The approach described herein proposes the development of ENR formulations by co-electrospinning ENR with custom-prepared cyclodextrin–oligolactide (CDLA) derivatives. This method benefits from the high solubility of these derivatives, enabling polymer-free electrospinning. The electrospinning parameters were optimized to incorporate significant amounts of ENR into the CDLA nanofibrous webs, reaching up to 15.6% by weight. The obtained formulations were characterized by FTIR and NMR spectroscopy methods and evaluated for their antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. This study indicates that the presence of CDLA derivative does not inhibit the antibacterial activity of ENR, recommending these formulations for further development. Full article
(This article belongs to the Special Issue Advances in Polymeric Drug Delivery Systems, 2nd Edition)
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19 pages, 3619 KiB  
Article
Development, Characterization, and Evaluation of Potential Systemic Toxicity of a Novel Oral Melatonin Formulation
by Catalina N. Cheaburu-Yilmaz, Kemal Atmaca, Onur Yilmaz and Hilmi Orhan
Pharmaceutics 2024, 16(7), 871; https://doi.org/10.3390/pharmaceutics16070871 - 28 Jun 2024
Cited by 2 | Viewed by 1018
Abstract
The need to create safe materials for biomedical and pharmaceutical applications has become a significant driving force for the development of new systems. Therefore, a chitosan-coated copolymer of itaconic acid, acrylic acid, and N-vinyl caprolactam (IT-AA-NVC) was prepared by radical polymerization and subsequent [...] Read more.
The need to create safe materials for biomedical and pharmaceutical applications has become a significant driving force for the development of new systems. Therefore, a chitosan-coated copolymer of itaconic acid, acrylic acid, and N-vinyl caprolactam (IT-AA-NVC) was prepared by radical polymerization and subsequent coating via nanoprecipitation to give a system capable of sustained delivery of melatonin. Although melatonin brings undoubted benefits to the human body, aspects of the optimal dose, route, and time of administration for the obtaining of suitable treatment outcomes remain under discussion. The entrapment of melatonin in biocompatible polymeric systems can prevent its oxidation, decrease its toxicity, and provide an increased half-life, resulting in an enhanced pharmacokinetic profile with improved patient compliance. The structures of the biopolymer and conjugate were proven by FTIR, thermal properties were tested by DSC, and the morphologies were followed by SEM. The loading efficiency and in vitro release profile were studied by means of HPLC, and a delayed release profile with an initial burst was obtained. The potential systemic toxicity of the formulation was studied in vivo; a mild hepatotoxicity was observed following administration of the melatonin-loaded formulation to mice, both by histopathology and blood clinical biochemistry. Histopathology showed a mild nephrotoxicity as well; however, kidney clinical biochemistry did not support this. Full article
(This article belongs to the Special Issue Advances in Polymeric Drug Delivery Systems, 2nd Edition)
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