Therapeutic Drugs and Delivery Strategies for Gastrointestinal Diseases

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Clinical Pharmaceutics".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 1573

Special Issue Editors


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Guest Editor
Department of Chemical Engineering and Adelson School of Medicine, Ariel University, Ariel 4070000, Israel
Interests: targeted drug delivery; peptide-drug-conjugates; Cellular immunotherapy; animal models of cancer
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Guest Editor
Department of Pediatrics, Seattle Children’s Hospital, University of Washington, 4800 Sandpoint Way NE, Seattle, WA 98105, USA
Interests: therapeutics in nflammatory bowel disease; eosinophilic esophagitis; gastrointestinal disease

Special Issue Information

Dear Colleagues,

Ailments of the gastrointestinal (GI) tract are commonly reported across the world in both adult and pediatric populations. The GI tract is home to a complex system of immune cells collectively called the mucosal immune system. In both states of health and disease, the mucosal immune system plays a crucial role in how the gastrointestinal tract operates on a daily basis. The therapies and pharmacologic agents used to treat mucosal diseases, such as inflammatory bowel disease, Celiac disease, and eosinophilic and non-eosinophilic diseases, have improved in recent years. These newer agents, drug dosages, therapy forms, and therapeutic preparation still constitute areas of exploration and discovery. As science advances, the clinical application and placement of these therapies will be vital to understand as we begin to tailor individual therapy to each patient’s disease.

Prof. Dr. Michael A. Firer
Dr. Hengqi Zheng
Guest Editors

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Keywords

  • targeted therapy in drug delivery
  • biologic therapies in inflammatory bowel disease (e.g., special dosages, administration and delivery)
  • biologic therapies in eosinophilic esophagitis (e.g., special dosages, administration and delivery)
  • eosinophilic gastrointestinal disease

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Published Papers (2 papers)

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Research

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16 pages, 2276 KiB  
Article
Passive Immunotherapy of Cynomolgus Monkeys with Anti-Rotavirus IgY
by Gentil Arthur Bentes, Juliana Rodrigues Guimarães, Eduardo de Mello Volotão, Natália Maria Lanzarini, Alexandre dos Santos da Silva, Noemi Rovaris Gardinali, Renato Sergio Marchevsky, José Paulo Gagliardi Leite, Jaqueline Mendes de Oliveira and Marcelo Alves Pinto
Pharmaceutics 2024, 16(9), 1149; https://doi.org/10.3390/pharmaceutics16091149 - 30 Aug 2024
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Abstract
Immunoglobulins Y (IgY) purified from egg yolks of hens represents an attractive, cost-effective alternative for the development of new diagnostic and therapeutic platforms. In this study, we evaluated the therapeutic efficacy of rotavirus-specific IgY in a cynomolgus monkey (Macaca fascicularis) model. [...] Read more.
Immunoglobulins Y (IgY) purified from egg yolks of hens represents an attractive, cost-effective alternative for the development of new diagnostic and therapeutic platforms. In this study, we evaluated the therapeutic efficacy of rotavirus-specific IgY in a cynomolgus monkey (Macaca fascicularis) model. Animals were experimentally infected with human rotavirus Group A (RVA), the most common cause of severe acute diarrhoea among young children worldwide. Animals were administered human RVA (3.1 × 107 FFU/mL) by oral gavage, challenged with 2.5 mg of anti-RVA IgY orally, and monitored for five days according to clinical, haematological and biochemical parameters; serum electrolyte levels; viral shedding; and histopathological changes. Immunotherapy with anti-RVA IgY had a protective effect against severe rotavirus-induced enteritis in four of the ten treated monkeys, as evidenced by histopathological findings. Although only one animal had diarrhoea, all but one exhibited virus shedding regardless of the treatment. Full article
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13 pages, 278 KiB  
Review
The Use of Tissue Concentrations of Biological and Small-Molecule Therapies in Clinical Studies of Inflammatory Bowel Diseases
by Ahmed B. Bayoumy, Luc J. J. Derijks, Bas Oldenburg and Nanne K. H. de Boer
Pharmaceutics 2024, 16(12), 1497; https://doi.org/10.3390/pharmaceutics16121497 - 22 Nov 2024
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Abstract
Abstract: The introduction of biological therapies has revolutionized inflammatory bowel disease (IBD) management. A critical consideration in developing these therapies is ensuring adequate drug concentrations at the site of action. While blood-based biomarkers have shown limited utility in optimizing treatment (except for TNF-alpha [...] Read more.
Abstract: The introduction of biological therapies has revolutionized inflammatory bowel disease (IBD) management. A critical consideration in developing these therapies is ensuring adequate drug concentrations at the site of action. While blood-based biomarkers have shown limited utility in optimizing treatment (except for TNF-alpha inhibitors and thiopurines), tissue drug concentrations may offer valuable insights. In antimicrobial therapies, tissue concentration monitoring is standard practice and could provide a new avenue for understanding the pharmacokinetics of biological and small-molecule therapies in IBD. Various methods exist for measuring tissue concentrations, including whole tissue sampling, MALDI-MSI, microdialysis, and fluorescent labeling. These techniques offer unique advantages, such as spatial drug-distribution mapping, continuous sampling, or cellular-level analysis. However, challenges remain, including sampling invasiveness, heterogeneity in tissue compartments, and a lack of standardized bioanalytical guidelines. Drug pharmacokinetics are influenced by multiple factors, including molecular properties, disease-induced changes in the gastrointestinal tract, and the timing of sample collection. For example, drug permeability, solubility, and interaction with transporters may vary between Crohn’s disease and ulcerative colitis. Research into the tissue concentrations of drugs like anti-TNF agents, ustekinumab, vedolizumab, and tofacitinib has shown variable correlations with clinical outcomes, suggesting potential roles for tissue concentration monitoring in therapeutic drug management. Although routine clinical application is not yet established, exploring tissue drug concentrations may enhance understanding of IBD pharmacotherapy. Full article
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