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Pharmaceutics
Special Issues
Functional Nanomaterials in Pharmaceutics: Current Uses and Potential Applications
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Functional Nanomaterials in Pharmaceutics: Current Uses and Potential Applications

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 10 July 2025 | Viewed by 2340

Special Issue Editors

Dr. Claudiu Morgovan

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Guest Editor
Faculty of Medicine, Lucian Blaga University, 2A, Lucian Blaga Str., 550169 Sibiu, Romania
Interests: pharmacology; drug safety; antimicrobial resistance; drug efficacy
Special Issues, Collections and Topics in MDPI journals
Dr. Adina Frum

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Guest Editor
Preclinical Department, Faculty of Medicine, “Lucian Blaga” University of Sibiu, 2A Lucian Blaga St., 550169 Sibiu, Romania
Interests: phytochemical analyses; antioxidants; polyphenols; environmental sciences; natural products; nutrivigilance; dendrimers; drug delivery
Special Issues, Collections and Topics in MDPI journals
Dr. Anca Butuca

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Guest Editor
Preclinical Department, Faculty of Medicine, “Lucian Blaga” University of Sibiu, 2A Lucian Blaga St., 550169 Sibiu, Romania
Interests: pharmacovigilance; drug delivery; dendrimers; drug delivery systems; targeted drug delivery; formulation; natural products
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The complexity of some diseases as well as the intrinsic toxicity of some drugs have sparked interest in the innovation and improvement of drug delivery agents like nanomaterials. Due to their unique potential and flexibility, they are attracting significant interest from scientists in terms of addressing the delivery of drugs with low solubility, high toxicity, and low bioavailability.

Nanotechnology is currently essential for the biomedical sector because it can contribute to targeted drug delivery by using nanomaterials as a transport vehicle for active substances.

Nanomedicines are molecular systems that allow the encapsulation of several different components obtained at a nanoscopic scale in order to optimize drug delivery.

Currently, the use of nanoparticles has a wide applicability in diagnostics and in the distribution of drugs, which allow the minimization of adverse reactions, the faster absorption of drugs, and targeted action at the level of specific cells or organs while simultaneously obtaining the desired results.

In the present Special Issue, we invite authors to send their manuscripts covering aspects from the entire field, such as synthesis, characterization methods, molecular simulations, regulatory, biological or clinical studies, potential applications in biomedicine, pharmacokinetics improvement, safety, toxicity reduction, etc.

Dr. Claudiu Morgovan
Dr. Adina Frum
Dr. Anca Butuca
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • nanotechnology
  • nanocarriers
  • nanoparticles
  • bioavailability
  • drug delivery systems
  • targeted drug delivery
  • formulation
  • drug development
  • drug safety
  • toxicity

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Published Papers (2 papers)

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Research

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26 pages, 7186 KiB  
Article
Biomedical Application Prospects of Gadolinium Oxide Nanoparticles for Regenerative Medicine
by Ekaterina V. Silina, Natalia E. Manturova, Elena L. Chuvilina, Akhmedali A. Gasanov, Olga I. Andreeva, Maksim A. Pugachevskii, Aleksey V. Kochura, Alexey A. Kryukov, Yulia G. Suzdaltseva and Victor A. Stupin
Pharmaceutics 2024, 16(12), 1627; https://doi.org/10.3390/pharmaceutics16121627 - 23 Dec 2024
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Abstract
Background/Objectives: The aim was to study the possibilities of biomedical application of gadolinium oxide nanoparticles (Gd2O3 NPs) synthesized under industrial conditions, and evaluate their physicochemical properties, redox activity, biological activity, and safety using different human cell lines. Methods: The powder [...] Read more.
Background/Objectives: The aim was to study the possibilities of biomedical application of gadolinium oxide nanoparticles (Gd2O3 NPs) synthesized under industrial conditions, and evaluate their physicochemical properties, redox activity, biological activity, and safety using different human cell lines. Methods: The powder of Gd2O3 NPs was obtained by a process of thermal decomposition of gadolinium carbonate precipitated from nitrate solution, and was studied using transmission electron microscopy (TEM), X-ray diffraction (XRD), Raman spectroscopy, mass spectrometry, and scanning electron microscopy (SEM) with energy dispersive X-ray analyzer (EDX). The redox activity of different concentrations of Gd2O3 NPs was studied by the optical spectroscopy (OS) method in the photochemical degradation process of methylene blue dye upon irradiation with an optical source. Biological activity was studied on different human cell lines (keratinocytes, fibroblasts, mesenchymal stem cells (MSCs)) with evaluation of the effect of a wide range of Gd2O3 NP concentrations on metabolic and proliferative cellular activity (MTT test, direct cell counting, dead cell assessment, and visual assessment of cytoarchitectonics). The test of migration activity assessment on a model wound was performed on MSC culture. Results: According to TEM data, the size of the NPs was in the range of 2–43 nm, with an average of 20 nm. XRD analysis revealed that the f Gd2O3 nanoparticles had a cubic structure (C-form) of Gd2O3 (Ia3)¯ with lattice parameter a = 10.79(9) Å. Raman spectroscopy showed that the f Gd2O3 nanoparticles had a high degree of crystallinity. By investigating the photooxidative degradation of methylene blue dye in the presence of f Gd2O3 NPs under red light irradiation, it was found that f Gd2O3 nanoparticles showed weak antioxidant activity, which depended on the particle content in the solution. At a concentration of 10−3 M, the highest antioxidant activity of f Gd2O3 nanoparticles was observed when the reaction rate constant of dye photodegradation decreased by 5.5% to 9.4 × 10−3 min−1. When the concentration of f Gd2O3 NPs in solution was increased to 10−2 M upon irradiation with a red light source, their antioxidant activity changed to pro-oxidant activity, accompanied by a 15% increase in the reaction rate of methylene blue degradation. Studies on cell lines showed a high level of safety and regenerative potential of Gd2O3 NPs, which stimulated fibroblast metabolism at a concentration of 10−3 M (27% enhancement), stimulated keratinocyte metabolism at concentrations of 10−3 M–10−5 M, and enhanced keratinocyte proliferation by an average of 35% at concentrations of 10−4 M. Furthermore, it accelerated the migration of MSCs, enhancing their proliferation, and promoting the healing of the model wound. Conclusions: The results of the study demonstrated the safety and regenerative potential of redox-active Gd2O3 NPs towards different cell lines. This may be the basis for further research to develop nanomaterials based on Gd2O3 NPs for skin wound healing and in regenerative medicine generally. Full article
(This article belongs to the Special Issue Functional Nanomaterials in Pharmaceutics: Current Uses and Potential Applications)
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Review

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52 pages, 8840 KiB  
Review
Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment
by Fatih Ciftci, Ali Can Özarslan, İmran Cagri Kantarci, Aslihan Yelkenci, Ozlem Tavukcuoglu and Mansour Ghorbanpour
Pharmaceutics 2025, 17(1), 121; https://doi.org/10.3390/pharmaceutics17010121 - 16 Jan 2025
Viewed by 841
Abstract
In the 21st century, thanks to advances in biotechnology and developing pharmaceutical technology, significant progress is being made in effective drug design. Drug targeting aims to ensure that the drug acts only in the pathological area; it is defined as the ability to [...] Read more.
In the 21st century, thanks to advances in biotechnology and developing pharmaceutical technology, significant progress is being made in effective drug design. Drug targeting aims to ensure that the drug acts only in the pathological area; it is defined as the ability to accumulate selectively and quantitatively in the target tissue or organ, regardless of the chemical structure of the active drug substance and the method of administration. With drug targeting, conventional, biotechnological and gene-derived drugs target the body’s organs, tissues, and cells that can be selectively transported to specific regions. These systems serve as drug carriers and regulate the timing of release. Despite having many advantageous features, these systems have limitations in thoroughly treating complex diseases such as cancer. Therefore, combining these systems with nanoparticle technologies is imperative to treat cancer at both local and systemic levels effectively. The nanocarrier-based drug delivery method involves encapsulating target-specific drug molecules into polymeric or vesicular systems. Various drug delivery systems (DDS) were investigated and discussed in this review article. The first part discussed active and passive delivery systems, hydrogels, thermoplastics, microdevices and transdermal-based drug delivery systems. The second part discussed drug carrier systems in nanobiotechnology (carbon nanotubes, nanoparticles, coated, pegylated, solid lipid nanoparticles and smart polymeric nanogels). In the third part, drug targeting advantages were discussed, and finally, market research of commercial drugs used in cancer nanotechnological approaches was included. Full article
(This article belongs to the Special Issue Functional Nanomaterials in Pharmaceutics: Current Uses and Potential Applications)
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