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Pharmaceutics
Special Issues
Skin Immunomodulation: Drugs, Antibodies and Vaccines
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Skin Immunomodulation: Drugs, Antibodies and Vaccines

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 7747

Special Issue Editors

Dr. Huiying Li

E-Mail Website
Guest Editor
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90012, USA
Interests: immunomodulation; skin immunity; bioinformatics
Prof. Dr. Eric (Chun-Ming) Huang

E-Mail Website1 Website2
Guest Editor
Department of Biomedical Sciences and Engineering, National Central University, Taoyuan 32001, Taiwan
Interests: skin microbiome; acne vaccine; beneficial microbes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Human skin consists of various immune cells and microbes and acts as an active immune organ. Immunity in skin functions as a barrier, which is the first line of innate immune defense against pathogens. Disruption of skin immunity, including dysfunction of immune cells and dysbiotic skin microbiome, can result in various skin diseases. Skin immunomodulation using drugs, antibodies, vaccines, and others provides a new modality for the treatment of skin diseases. These modalities become advanced pharmacotherapeutics of human diseases.

This Special Issue aims to collect manuscripts on research related to drugs, antibodies, vaccines, probiotics, prebiotics, or postbiotics for curing or preventing skin diseases. We will also collect manuscripts on the development of new delivery methods for effective pharmacotherapeutics to the skin. In this Special Issue, original research articles and reviews are welcome.

We look forward to receiving your contributions.

Dr. Huiying Li
Prof. Dr. Eric (Chun-Ming) Huang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skin immunomodulation
  • microbiome
  • drugs
  • antibodies
  • vaccines
  • drug delivery

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Published Papers (2 papers)

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Research

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17 pages, 9859 KiB  
Article
Modulation of Skin Inflammatory Responses by Aluminum Adjuvant
by Yanhang Liao, Lixiang Sun, Meifeng Nie, Jiacheng Li, Xiaofen Huang, Shujun Heng, Wenlu Zhang, Tian Xia, Zhuolin Guo, Qinjian Zhao and Ling-juan Zhang
Pharmaceutics 2023, 15(2), 576; https://doi.org/10.3390/pharmaceutics15020576 - 8 Feb 2023
Cited by 3 | Viewed by 2500
Abstract
Aluminum salt (AS), one of the most commonly used vaccine adjuvants, has immuno-modulatory activity, but how the administration of AS alone may impact the activation of the skin immune system under inflammatory conditions has not been investigated. Here, we studied the therapeutic effect [...] Read more.
Aluminum salt (AS), one of the most commonly used vaccine adjuvants, has immuno-modulatory activity, but how the administration of AS alone may impact the activation of the skin immune system under inflammatory conditions has not been investigated. Here, we studied the therapeutic effect of AS injection on two distinct skin inflammatory mouse models: an imiquimod (IMQ)-induced psoriasis-like model and an MC903 (calcipotriol)—induced atopic dermatitis-like model. We found that injection of a high dose of AS not only suppressed the IMQ-mediated development of T-helper 1 (Th1) and T-helper 17 (Th17) immune responses but also inhibited the IMQ-mediated recruitment and/or activation of neutrophils and macrophages. In contrast, AS injection enhanced MC903-mediated development of the T-helper 2 (Th2) immune response and neutrophil recruitment. Using an in vitro approach, we found that AS treatment inhibited Th1 but promoted Th2 polarization of primary lymphocytes, and inhibited activation of peritoneal macrophages but not bone marrow derived neutrophils. Together, our results suggest that the injection of a high dose of AS may inhibit Th1 and Th17 immune response-driven skin inflammation but promote type 2 immune response-driven skin inflammation. These results may provide a better understanding of how vaccination with an aluminum adjuvant alters the skin immune response to external insults. Full article
(This article belongs to the Special Issue Skin Immunomodulation: Drugs, Antibodies and Vaccines)
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Review

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18 pages, 1474 KiB  
Review
Advances in Biomedical Functions of Natural Whitening Substances in the Treatment of Skin Pigmentation Diseases
by Fan Liu, Linkai Qu, Hua Li, Jiaxuan He, Lei Wang, Yimeng Fang, Xiaoqing Yan, Qinsi Yang, Bo Peng, Wei Wu, Libo Jin and Da Sun
Pharmaceutics 2022, 14(11), 2308; https://doi.org/10.3390/pharmaceutics14112308 - 27 Oct 2022
Cited by 18 | Viewed by 4833
Abstract
Pigmentation diseases can lead to significant color differences between the affected part and the normal part, resulting in severe psychological and emotional distress among patients. The treatment of pigmentation diseases with good patient compliance is mainly in the form of topical drugs. However, [...] Read more.
Pigmentation diseases can lead to significant color differences between the affected part and the normal part, resulting in severe psychological and emotional distress among patients. The treatment of pigmentation diseases with good patient compliance is mainly in the form of topical drugs. However, conventional hydroquinone therapy contributes to several pathological conditions, such as erythema, dryness, and skin desquamation, and requires a longer treatment time to show significant results. To address these shortcomings, natural whitening substances represented by kojic acid and arbutin have gradually become the candidate ingredients of traditional local preparations due to their excellent biological safety. This review focuses on several natural whitening substances with potential therapeutic effects in pigmentation disease and their mechanisms, and a thorough discussion has been conducted into the solution methods for the challenges involved in the practical application of natural whitening substances. Full article
(This article belongs to the Special Issue Skin Immunomodulation: Drugs, Antibodies and Vaccines)
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