Pharmaceutics 2020 Young Investigators' Contributions Collection

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 4300

Special Issue Editors


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Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK
Interests: particulate systems and formulations for drug delivery; vaccine adjuvanticity and diagnostics
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Guest Editor
Leicester Institute for Pharmaceutical Innovation, Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK
Interests: drug delivery; controlled release; nanomedicine; vaccine delivery; transdermal delivery; microneedles; diagnostics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Pharmaceutics aims to compile the current trends and research directions of internationally renowned and successful young pharmaceutical scientists in one dedicated Special Issue. The idea for this Special Issue has arisen from the numerous and, above all, brilliant nominations for 2020 Young Investigator Award. It was the easiest-ever choice for us to publicly share the fascinating and thrilling research successes of the nominated scientists with you, our dear peer readers.

For this prestigious Special Issue, the journal Pharmaceutics will only accept original research papers that have been invited exclusively by the editors. The contributions to this Special Issue will highlight the current state-of-the-art in the fields of pharmaceutical formulation, process development, drug delivery, pharmacokinetics, biopharmaceutics, pharmacogenetics, and interdisciplinary research involving, but not limited to, engineering, biomedical sciences, and cell biology.

Please enjoy reading these high-end research highlights!

Prof. Dr. Yvonne Perrie
Dr. Ana Sara Cordeiro
Guest Editors

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Published Papers (1 paper)

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Research

11 pages, 1107 KiB  
Article
Viscoelastic and Deformation Characteristics of Structurally Different Commercial Topical Systems
by Maryam Dabbaghi, Sarika Namjoshi, Bhavesh Panchal, Jeffrey E. Grice, Sangeeta Prakash, Michael Stephen Roberts and Yousuf Mohammed
Pharmaceutics 2021, 13(9), 1351; https://doi.org/10.3390/pharmaceutics13091351 - 27 Aug 2021
Cited by 35 | Viewed by 3345
Abstract
Rheological characteristics and shear response have potential implication in defining the pharmaceutical equivalence, therapeutic equivalence, and perceptive equivalence of commercial topical products. Three creams (C1 and C3 as oil-in-water and C2 as water-in-oil emulsions), and two gels (G1 and G2 carbomer-based) were characterized [...] Read more.
Rheological characteristics and shear response have potential implication in defining the pharmaceutical equivalence, therapeutic equivalence, and perceptive equivalence of commercial topical products. Three creams (C1 and C3 as oil-in-water and C2 as water-in-oil emulsions), and two gels (G1 and G2 carbomer-based) were characterized using the dynamic range of controlled shear in steady-state flow and oscillatory modes. All products, other than C3, met the Critical Quality Attribute criteria for high zero-shear viscosity (η0) of 2.6 × 104 to 1.5 × 105 Pa∙s and yield stress (τ0) of 55 to 277 Pa. C3 exhibited a smaller linear viscoelastic region and lower η0 (2547 Pa∙s) and τ0 (2 Pa), consistent with lotion-like behavior. All dose forms showed viscoelastic solid behavior having a storage modulus (G′) higher than the loss modulus (G″) in the linear viscoelastic region. However, the transition of G′ > G″ to G″ > G′ during the continual strain increment was more rapid for the creams, elucidating a relatively brittle deformation, whereas these transitions in gels were more prolonged, consistent with a gradual disentanglement of the polymer network. In conclusion, these analyses not only ensure quality and stability, but also enable the microstructure to be characterized as being flexible (gels) or inelastic (creams). Full article
(This article belongs to the Special Issue Pharmaceutics 2020 Young Investigators' Contributions Collection)
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