Targeted Drug Delivery to the Brain
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".
Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 10707
Special Issue Editors
Interests: brain drug targeting; blood-brain barrier transport; nose-to-brain drug delivery
Interests: drug delivery system; ASO/siRNA delivery; nose-to-brain delivery; topical application; polymer-based micelles; liposomes; functional peptides; spinal cord diseases; CNS disorders
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Special Issue Information
Dear Colleagues,
We would like to invite you to contribute to this Special Issue entitled “Targeted Drug Delivery to the Brain”.
The number of neurodegenerative diseases such as Alzheimer’s disease and vascular dementia is increasing rapidly, and the development of superior therapeutic agents is expected. Drug transfer to the brain is mainly controlled by the substance transfer function of the blood–brain barrier (BBB). To overcome the BBB, compounds can be structurally modified, providing them with physicochemical properties that promote their passive diffusion, taking advantage of the uptake and transport systems operating through endogenous transporters and receptors expressed on the BBB, or designing structures that are not recognized by the efflux transport system. With advances in research technology, the anatomical entities of the BBB and the expression of transport-related proteins have been elucidated, but the full picture of the BBB transport function of drugs is not clear yet. Therefore, the development of brain delivery systems using endogenous BBB permeation systems will become more important as more diverse central nervous system drugs are made available. On the other hand, it is possible to use potential routes that bypass or avoid the BBB. In recent years, the existence of a nasal-to-brain route has attracted attention for direct drug delivery to the brain and the central nervous system. This nose-to-brain delivery route is also expected to be non-invasive and effective for peptides and nucleic acid drugs that are difficult to directly administer in the central nervous system by conventional methods such as the oral and intravenous routes. Currently, many researchers are focusing on nose-to-brain delivery technologies and transport mechanisms for a variety of compounds, from small molecules to biopharmaceuticals. In order to efficiently deliver drugs from the nose to the central nervous system, it is essential to design a drug delivery system based on drug nanocarriers that is retained in the intranasal cavity and promotes drug permeability in the nasal mucosa. Considering this scenario, this Special Issue invites articles dealing with the following topics:
- Blood–brain barrier transport
- Transport mechanisms at the blood–brain barrier
- Drug delivery systems to the brain.
- Intranasal delivery to the brain
- Transport mechanisms from nose to brain
Prof. Toyofumi Suzuki
Dr. Takanori Kanazawa
Guest Editors
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Keywords
- targeted drug delivery
- CNS drug delivery
- enhancing delivery
- nanocarriers
- nanoparticles
- nanopharmaceuticals
- nanomedicine: pharmaceutical nanotechnology
- blood–brain barrier
- transporter
- transport mechanism
- intranasal delivery
- intranasal delivery device
- nasal route
- nose-to-brain delivery: route of delivery
- mucoadhesion
- mucos-penetrating particles
- brain disease
- neurological disorders
- brain injury
- central nervous disorder
- neurodegenerative diseases
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