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Polymers
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Electrospun Nanofibrous Membrane for Delivery of Antimicrobial Agents
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Electrospun Nanofibrous Membrane for Delivery of Antimicrobial Agents

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Fibers".

Deadline for manuscript submissions: closed (25 May 2023) | Viewed by 7344

Special Issue Editors

Dr. Chen-Hung Lee

E-Mail Website
Guest Editor
Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan 33305, Taiwan
Interests: bioabsorbable medical devices; drug delivery; tissue engineering
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Shih-Jung Liu

E-Mail Website
Guest Editor
Mechanical Engineering, Chang Gung University Adjunct Professor, Orthopedic Surgery, Chang Gung Memorial Hospital Tao-Yuan, Taoyuan 33302, Taiwan
Interests: bioabsorbable medical devices; drug delivery; tissue engineering; nanofibers; core-shell microspheres
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Nanotechnology has gained an increased interest in several different areas of biotechnology, including tissue engineering and drug delivery via nanofibers. Drug delivery systems facilitate controlled drug supply with respect to time, quantity and location. This is primarily made possible because of the creation of nanofibrous scaffolds that are capable of biomimicking the extracellular matrix (ECM). Electrospinning can be used to successfully generate nanofibers with sizes well within the range of those of the fibers present in the ECM (50–500 nm), which plays an important role in regulating cellular behaviors by influencing cells with the help of biochemical signals and topographical cues. Various parameters can also affect the release behavior of drugs from electrospun nanofibers, including the molecular weight, composition and crystallinity of the matrix, processing conditions, the extent and distribution of drugs and application environment. This Special Issue aims to highlight the most popular applications of nanofibers related to the delivery of antimicrobial agents for various diseases. Reports of fundamental scientific investigations are welcome, and so are articles correlated to the practical applications of nanofibers in tissue engineering and drug delivery. Both experimental and theoretical work is of interest, and theoretical papers will generally include the comparison of predictions with experimental data.

Dr. Chen-Hung Lee
Prof. Dr. Shih-Jung Liu
Guest Editors

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Keywords

  • electrospinning
  • nanofibers
  • antimicrobial agents
  • drug delivery system
  • infection

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Published Papers (3 papers)

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Research

15 pages, 4755 KiB  
Article
Facile One-Step Electrospinning Process to Prepare AgNPs-Loaded PLA and PLA/PEO Mats with Antibacterial Activity
by Valeria Allizond, Giuliana Banche, Matteo Salvoni, Mery Malandrino, Claudio Cecone, Anna Maria Cuffini and Pierangiola Bracco
Polymers 2023, 15(6), 1470; https://doi.org/10.3390/polym15061470 - 16 Mar 2023
Cited by 17 | Viewed by 2667
Abstract
Nanofibers can play an important role in developing new kinds of medical applications. Poly(lactic acid) (PLA) and PLA/poly(ethylene oxide) (PEO) antibacterial mats containing silver nanoparticles (AgNPs) were prepared by a simple one-step electrospinning method that allows AgNPs to be synthesized simultaneously with the [...] Read more.
Nanofibers can play an important role in developing new kinds of medical applications. Poly(lactic acid) (PLA) and PLA/poly(ethylene oxide) (PEO) antibacterial mats containing silver nanoparticles (AgNPs) were prepared by a simple one-step electrospinning method that allows AgNPs to be synthesized simultaneously with the preparation of the electrospinning solution. The electrospun nanofibers were characterized by scanning electron microscopy, transmission electron microscopy and thermogravimetry, while silver release over time was monitored by inductively coupled plasma/optical emission spectroscopy. The antibacterial activity was tested against Staphylococcus epidermidis and Escherichia coli by colony forming unit (CFU) count on agar after 15, 24 and 48 h of incubation. AgNPs were found to be mainly concentrated in the PLA nanofiber core, and the mats showed steady but slow Ag release in the short term; in contrast, AgNPs were uniformly distributed in the PLA/PEO nanofibers, which released up to 20% of their initial silver content in 12 h. A significant (p < 0.05) antimicrobial effect towards both tested bacteria, highlighted by a reduction in the CFU/mL counts, was observed for the nanofibers of PLA and PLA/PEO embedded with AgNPs, with a stronger effect exerted by the latter, confirming the more efficient silver release from these samples. The prepared electrospun mats may have good potential for use in the biomedical field, particularly in wound dressing applications, where a targeted delivery of the antimicrobial agent is highly desirable to avoid infections. Full article
(This article belongs to the Special Issue Electrospun Nanofibrous Membrane for Delivery of Antimicrobial Agents)
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14 pages, 8061 KiB  
Article
A Composite of Hydrogel Alginate/PVA/r-GO for Scaffold Applications with Enhanced Degradation and Biocompatibility Properties
by Amaliya Rasyida, Salma Halimah, Ika Dewi Wijayanti, Sigit Tri Wicaksono, Haniffudin Nurdiansah, Yohannes Marudut Tua Silaen, Yatim Lailun Ni’mah, Hosta Ardhyananta and Agung Purniawan
Polymers 2023, 15(3), 534; https://doi.org/10.3390/polym15030534 - 19 Jan 2023
Cited by 7 | Viewed by 2461
Abstract
We reported in this study the interrelation between the addition of 0.4, 0.8, 1.2, and 1.6 wt. % reduced graphene oxide (r-GO) into PVA/Alginate and their degradation and biocompatibility properties. The r-GO was synthesized by using the Hummer’s method. A crosslinker CaSO4 [...] Read more.
We reported in this study the interrelation between the addition of 0.4, 0.8, 1.2, and 1.6 wt. % reduced graphene oxide (r-GO) into PVA/Alginate and their degradation and biocompatibility properties. The r-GO was synthesized by using the Hummer’s method. A crosslinker CaSO4 was added to prepare Alginate/PVA/r-GO Hydrogel composite. A Field Emission in Lens (FEI)-scanning electron microscopy (SEM), along with X-ray energy dispersive spectroscopy (EDS), was performed, characterizing the morphology of the composite. A compressive test was conducted, determining the mechanical properties of the composite with the highest achieved 0.0571 MPa. Furthermore, in vitro cytotoxicity was conducted to determine the biocompatibility properties of the studied composite. An MTT assay was applied to measure cell viability. In general, the presence of r-GO was found to have no significant effect on the morphology of the hydrogel. Indeed, adding 0.4% r-GO to the PVA/Alginate increased the cell viability up to 122.26 ± 0.93, indicating low toxicity. The studied composites have almost no changes in weight and shape, which proves that low degradation occurred in addition to this after 28 days of immersion in saline phosphate buffer solution. In conclusion, achieving minimal degradation and outstanding biocompatibility lead to PVA/Alginate/r-GO hydrogel composites being the most attractive materials for tissue engineering applications. Full article
(This article belongs to the Special Issue Electrospun Nanofibrous Membrane for Delivery of Antimicrobial Agents)
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14 pages, 4666 KiB  
Article
Application of Multi-Layered Temperature-Responsive Polymer Brushes Coating on Titanium Surface to Inhibit Biofilm Associated Infection in Orthopedic Surgery
by Sookyung Choi, Hyeonjoon Lee, Ran Hong, Byungwook Jo and Suenghwan Jo
Polymers 2023, 15(1), 163; https://doi.org/10.3390/polym15010163 - 29 Dec 2022
Cited by 4 | Viewed by 1647
Abstract
Infection associated with biomedical implants remains the main cause of failure, leading to reoperation after orthopedic surgery. Orthopedic infections are characterized by microbial biofilm formation on the implant surface, which makes it challenging to diagnose and treat. One potential method to prevent and [...] Read more.
Infection associated with biomedical implants remains the main cause of failure, leading to reoperation after orthopedic surgery. Orthopedic infections are characterized by microbial biofilm formation on the implant surface, which makes it challenging to diagnose and treat. One potential method to prevent and treat such complications is to deliver a sufficient dose of antibiotics at the onset of infection. This strategy can be realized by coating the implant with thermoregulatory polymers and triggering the release of antibiotics during the acute phase of infection. We developed a multi-layered temperature-responsive polymer brush (MLTRPB) coating that can release antibiotics once the temperature reaches a lower critical solution temperature (LCST). The coating system was developed using copolymers composed of diethylene glycol methyl ether methacrylate and 2-hydroxyethyl methacrylate by alternatively fabricating monomers layer by layer on the titanium surface. LCST was set to the temperature of 38–40 °C, a local temperature that can be reached during infection. The antibiotic elution characteristics were investigated, and the antimicrobial efficacy was tested against S. aureus species (Xen29 ATCC 29 213) using one to four layers of MLTRPB. Both in vitro and in vivo assessments demonstrated preventive effects when more than four layers of the coating were applied, ensuring promising antibacterial effects of the MLTRPB coating. Full article
(This article belongs to the Special Issue Electrospun Nanofibrous Membrane for Delivery of Antimicrobial Agents)
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