Polymer Composites for Biomedical Applications

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: 20 January 2025 | Viewed by 1274

Special Issue Editors


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Guest Editor
Institute of Engineering Materials and Design, Faculty of Mechanical Engineering, University of Maribor, 2000 Maribor, Slovenia
Interests: electrospinning; polymers; nanocomposites; textile printing; textile care
Special Issues, Collections and Topics in MDPI journals
Institute of Engineering Materials and Design, Faculty of Mechanical Engineering, University of Maribor, 2000 Maribor, Slovenia
Interests: surface interactions; surface charge; coatings; biopolymers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Polymer composites have emerged as promising materials for various biomedical applications due to their unique properties and the ability to tailor their composition and structure for specific needs. This Special Issue highlights the latest research and developments in polymer composites for biomedical applications, covering topics such as tissue engineering, drug delivery, implants, and diagnostic devices.

The Special Issue welcomes submissions that focus on the synthesis, material development, characterization, and application of polymer composites in biomedicine.

The Special Issue will feature original research articles and review articles that present novel ideas, methodologies, and applications of polymer composites in the biomedical field. Contributions from both experimental and theoretical perspectives are welcome.

By bringing together researchers from various disciplines, including materials science, biomedical engineering, and polymer chemistry, this Special Issue aims to foster interdisciplinary collaborations among different research fields.

Dr. Manja Kurečič
Dr. Matej Bracic
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • composites
  • (multi)functional properties
  • structure
  • modification process
  • characterization
  • advanced applications
  • biomedicine

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Published Papers (1 paper)

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Research

24 pages, 7925 KiB  
Article
Cytotoxicity of Doxorubicin-Curcumin Nanoparticles Conjugated with Two Different Peptides (CKR and EVQ) against FLT3 Protein in Leukemic Stem Cells
by Fah Chueahongthong, Sawitree Chiampanichayakul, Natsima Viriyaadhammaa, Pornngarm Dejkriengkraikul, Siriporn Okonogi, Cory Berkland and Songyot Anuchapreeda
Polymers 2024, 16(17), 2498; https://doi.org/10.3390/polym16172498 - 2 Sep 2024
Viewed by 1061
Abstract
A targeted micellar formation of doxorubicin (Dox) and curcumin (Cur) was evaluated to enhance the efficacy and reduce the toxicity of these drugs in KG1a leukemic stem cells (LSCs) compared to EoL-1 leukemic cells. Dox-Cur-micelle (DCM) was developed to improve the cell uptake [...] Read more.
A targeted micellar formation of doxorubicin (Dox) and curcumin (Cur) was evaluated to enhance the efficacy and reduce the toxicity of these drugs in KG1a leukemic stem cells (LSCs) compared to EoL-1 leukemic cells. Dox-Cur-micelle (DCM) was developed to improve the cell uptake of both compounds in LSCs. Cur-micelle (CM) was produced to compare with DCM. DCM and CM were conjugated with two FLT3 (FMS-like tyrosine kinase)-specific peptides (CKR; C and EVQ; E) to increase drug delivery to KG1a via the FLT3 receptor (AML marker). They were formulated using a film-hydration technique together with a pH-induced self-assembly method. The optimal drug-to-polymer weight ratios for the DCM and CM formulations were 1:40. The weight ratio of Dox and Cur in DCM was 1:9. DCM and CM exhibited a particle size of 20–25 nm with neutral charge and a high %EE. Each micelle exhibited colloidal stability and prolonged drug release. Poloxamer 407 (P407) was modified with terminal azides and conjugated to FLT3-targeting peptides with terminal alkynes. DCM and CM coupled with peptides C, E, and C + E exhibited a higher particle size. Moreover, DCM-C + E and CM-C + E showed the highest toxicity in KG-1a and EoL-1 cells. Using two peptides likely improves the probability of micelles binding to the FLT3 receptor and induces cytotoxicity in leukemic stem cells. Full article
(This article belongs to the Special Issue Polymer Composites for Biomedical Applications)
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