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Polymers
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Electrospun Polymer Scaffold
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Electrospun Polymer Scaffold

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Processing and Engineering".

Deadline for manuscript submissions: closed (20 May 2019)

Special Issue Editor

Prof. Dr. Wojciech Swieszkowski

E-Mail Website
Guest Editor
Faculty of Materials Science and Engineering, Warsaw University of Technology, Warsaw, Poland
Interests: biomaterials; tissue engineering; bioprinting

Special Issue Information

Dear Colleagues,

Electrospinning has become a very popular technology among tissue engineering researchers, as a simple and versatile method for scaffolds’ fabrication. Highly porous electrospun fibrous constructs made of nanometer size fibers mimic the morphology of the native cellular environment of extracellular matrices. They play the important role of bioactive scaffolds in tissue regeneration, providing a 3D support structure for cells and new tissue to grow as well as delivering, if needed, proper biological factors to the cells. This Special Issue of Polymers (MDPI) entitled “Electrospun Polymer Scaffold” is dedicated to electrospun polymeric scaffolds, their fabrication, characterization, modifications, and cell–scaffolds interaction studies. The main aim is to bring up to date knowledge about innovations in electrospun scaffolds’ manufacturing, utilized materials, advancements in structures of fabricated constructs, and the possibilities of combining electrospinning and other fabrication methods in order to enhance the biocompatibility and biofunctionality of electrospun tissue engineering constructs.

Prof. Wojciech Swieszkowski
Guest Editor

Keywords

  • Electrospun polymer scaffolds
  • Nanofibrous scaffolds
  • Engineered fibrous scaffolds
  • Electrospun non-wovens for tissue scaffolds
  • Porous nanofibrous scaffolds
  • Biocompatible functionalization of nanofibers
  • Drug delivery nanofibrous scaffolds
  • Cell-nanofibrous material interactions
  • 3D nanofibrous scaffolds
  • Nanofibrous scaffold bio-compatibility
  • Melt electrospun scaffolds for tissue engineering applications

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Published Papers (2 papers)

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10 pages, 1656 KiB  
Article
Shear Force Fiber Spinning: Process Parameter and Polymer Solution Property Considerations
by Arzan C. Dotivala, Kavya P. Puthuveetil and Christina Tang
Polymers 2019, 11(2), 294; https://doi.org/10.3390/polym11020294 - 10 Feb 2019
Cited by 16 | Viewed by 5512
Abstract
For application of polymer nanofibers (e.g., sensors, and scaffolds to study cell behavior) it is important to control the spatial orientation of the fibers. We compare the ability to align and pattern fibers using shear force fiber spinning, i.e. contacting a drop of [...] Read more.
For application of polymer nanofibers (e.g., sensors, and scaffolds to study cell behavior) it is important to control the spatial orientation of the fibers. We compare the ability to align and pattern fibers using shear force fiber spinning, i.e. contacting a drop of polymer solution with a rotating collector to mechanically draw a fiber, with electrospinning onto a rotating drum. Using polystyrene as a model system, we observe that the fiber spacing using shear force fiber spinning was more uniform than electrospinning with the rotating drum with relative standard deviations of 18% and 39%, respectively. Importantly, the approaches are complementary as the fiber spacing achieved using electrospinning with the rotating drum was ~10 microns while fiber spacing achieved using shear force fiber spinning was ~250 microns. To expand to additional polymer systems, we use polymer entanglement and capillary number. Solution properties that favor large capillary numbers (>50) prevent droplet breakup to facilitate fiber formation. Draw-down ratio was useful for determining appropriate process conditions (flow rate, rotational speed of the collector) to achieve continuous formation of fibers. These rules of thumb for considering the polymer solution properties and process parameters are expected to expand use of this platform for creating hierarchical structures of multiple fiber layers for cell scaffolds and additional applications. Full article
(This article belongs to the Special Issue Electrospun Polymer Scaffold)
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13 pages, 3089 KiB  
Article
Electrospun Poly(γ–glutamic acid)/β–Tricalcium Phosphate Composite Fibrous Mats for Bone Regeneration
by Chun-Hsu Yao, Shau-Pei Yang, Yueh-Sheng Chen and Kuo-Yu Chen
Polymers 2019, 11(2), 227; https://doi.org/10.3390/polym11020227 - 1 Feb 2019
Cited by 15 | Viewed by 3223
Abstract
A poly(γ–glutamic acid)/β–tricalcium phosphate (γ–PGA/β–TCP) composite fibrous mat was fabricated using the electrospinning technique as a novel bone substitute. The mat was then cross-linked with cystamine in the presence of 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide to improve its water-resistant ability. Scanning electron micrographs revealed that the γ–PGA/β–TCP [...] Read more.
A poly(γ–glutamic acid)/β–tricalcium phosphate (γ–PGA/β–TCP) composite fibrous mat was fabricated using the electrospinning technique as a novel bone substitute. The mat was then cross-linked with cystamine in the presence of 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide to improve its water-resistant ability. Scanning electron micrographs revealed that the γ–PGA/β–TCP fibers had a uniform morphology with diameters ranging from 0.64 ± 0.07 µm to 1.65 ± 0.16 µm. The average diameter of the fibers increased with increasing cross-linking time. Moreover, increasing the cross-linking time and decreasing the γ–PGA/β–TCP weight ratio decreased the swelling ratio and in vitro degradation rate of the composite fibrous mat. In vitro experiments with osteoblast-like MG-63 cells demonstrated that the mat with a γ–PGA/β–TCP weight ratio of 20 and cross-linked time of 24 h had a higher alkaline phosphatase activity and better cell adhesion. Furthermore, the rat cranial bone defect was created and treated with the γ–PGA/β–TCP composite fibrous mat to evaluate its potential in bone regeneration. After 8 weeks of implantation, micro computed tomography showed that the γ–PGA/β–TCP composite fibrous mat promoted new bone growth. These observations suggest that the γ–PGA/β–TCP composite fibrous mat has a potential application in bone tissue engineering. Full article
(This article belongs to the Special Issue Electrospun Polymer Scaffold)
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