Neuropsychiatric and Quality of Life (QoL) Aspects of Multiple Sclerosis, 2nd Edition

A special issue of Sclerosis (ISSN 2813-3064).

Deadline for manuscript submissions: 20 October 2025 | Viewed by 840

Special Issue Editor


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Guest Editor
Neuropsychology and Behavioral Neurology Unit, Division of Molecular and Cognitive Neuroscience, Department of Psychology, University of Basel, Birmannsgasse 8, 4055 Basel, Switzerland
Interests: multiple sclerosis; Parkinson’s disease; dementia; depression; stress and cognition
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Special Issue Information

Dear Colleagues,

Multiple sclerosis (MS) remains one of the most prevalent chronic neurological disorders affecting young adults worldwide. Beyond the well-known sensorimotor challenges, MS often presents with a range of neuropsychiatric symptoms, including cognitive impairments, mood disturbances, and fatigue. These symptoms, which can sometimes appear as the initial manifestation of the disease, significantly affect both daily functioning and overall well-being. The impact of MS on quality of life (QoL) is profound, as these neuropsychiatric issues often become intertwined with the physical aspects of the disease.

Following the success of the first edition of this Special Issue, which featured 8 papers, we continue to explore the intricate relationship between cognitive and neuropsychiatric conditions in MS. This second edition invites original research articles, reviews, and case studies that advance our understanding of the impact of these conditions on mental health, QoL, and patient care. The aim is to further contribute to the growing body of knowledge and encourage interdisciplinary approaches that can lead to more effective management strategies for patients with MS facing these complex challenges.

Prof. Dr. Pasquale Calabrese
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sclerosis is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • multiple sclerosis
  • neuropsychiatric symptoms
  • quality of life
  • mental health

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Published Papers (1 paper)

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Research

15 pages, 1176 KiB  
Article
The Use of Augmented Reality on a Self-Paced Treadmill to Quantify Attention and Footfall Placement Variability in Middle-Aged to Older-Aged Adults with Multiple Sclerosis
by Manuel E. Hernandez, Roee Holtzer, Meltem Izzetoglu and Robert W. Motl
Sclerosis 2025, 3(1), 3; https://doi.org/10.3390/sclerosis3010003 - 17 Jan 2025
Viewed by 498
Abstract
Background/Objectives: Footfall placement variability is associated with falls in older adults and neurological diseases. Thus, the study of dual-task gait impairment in middle-aged to older-aged adults with multiple sclerosis (MS) is clinically relevant, particularly in environments that mimic the obstacles experienced in daily [...] Read more.
Background/Objectives: Footfall placement variability is associated with falls in older adults and neurological diseases. Thus, the study of dual-task gait impairment in middle-aged to older-aged adults with multiple sclerosis (MS) is clinically relevant, particularly in environments that mimic the obstacles experienced in daily ambulation. Methods: A total of 10 middle-aged to older-aged adults with MS (eight female, mean ± SD age = 56 ± 5 years), 12 healthy older adults (HOAs, nine female, age = 63 ± 4 years), and 10 healthy young adults (HYAs, five female, age = 22 ± 3) were asked to perform cued walking (CW) or obstacle walking (OW) tasks without or with a concurrent backward alphabet recitation task (CWT, OWT), or dual tasks. Gait performance and attentional demands were measured using hit rate, stride velocity, footfall placement bias and variance, and prefrontal cortex (PFC) oxygenated hemoglobin HbO levels. Results: A significant dual-task condition-by-cohort interaction was seen in footfall placement bias and variance as indicated by a higher footfall placement bias and variance in dual-task vs. single-task conditions seen in HOAs, in comparison to HYAs and adults with MS. Further, a significant walking condition-by-cohort interaction was seen in the HbO levels as indicated by the higher PFC HbO levels seen in OW vs. CW in adults with MS, compared to adults without MS. Conclusions: The decreased accuracy and increased attention in footfall placement to visual cues on the ground observed in adults with MS and HOAs, relative to HYAs, may provide a marker for gait impairment and fall risk in older adults with MS. Full article
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