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Cell Manipulation on a Microfluidic Device

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Sensors Development".

Deadline for manuscript submissions: closed (20 April 2024) | Viewed by 2110

Special Issue Editor

School of Microelectronics, Northwestern Polytechnical University, Xi’an 710072, China
Interests: lab on a chip; biochemical sensor; analytical chemistry; cell separation; microfluidics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The manipulation of fluids and particles is of vital importance in biotechnology, chemistry, and biomedical areas. Manipulations involve rotating, sorting, and trapping, which can be achieved through various approaches, such as acoustic waves, as well as optical, magnetic, and electric methods. Cell properties, including size, stiffness, and impedance, are key parameters when analyzing cellular processes. The interpretation of these properties has been recognized as a viable method for medical diagnosis and treatment influence evaluation. Methods developed to detect these properties in cells include atomic force microscopy, micro-pipe aspiration, optical tweezers, etc. However, these techniques generally suffer from low throughput with high costs. In this context, microfluidic systems have been exploited to probe the properties of cells. The development of methods for cell manipulation and characterization has shown great potential in diverse biomedical applications. Microfluidics is widely studied as a next-generation technology for cell manipulation and analysis because it provides methods for handling biological samples at the micro/nanoscale with high precision. We welcome the submission of manuscripts including, but not limited to, the following topics

  • novel designs, fabrication, and the control and modeling of microfluidic devices for cell sorting, isolation, detection, characterization, and analysis
  • new developments in microfluidic technologies for cell manipulation, characterization, and application.

Dr. Yupan Wu
Guest Editor

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Keywords

  • cell manipulation
  • cell characterization
  • microfluidics
  • biomedical applications

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Published Papers (1 paper)

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Research

17 pages, 9744 KiB  
Article
A Simulated Investigation of Lithium Niobate Orientation Effects on Standing Acoustic Waves
by Ranjith D. Janardhana and Nathan Jackson
Sensors 2023, 23(19), 8317; https://doi.org/10.3390/s23198317 - 8 Oct 2023
Cited by 1 | Viewed by 1658
Abstract
The integration of high-frequency acoustic waves with microfluidics has been gaining popularity as a method of separating cells/particles. A standing surface acoustic wave (sSAW) device produces constructive interference of the stationary waves, demonstrating an increase in cell separating efficiency without damaging/altering the cell [...] Read more.
The integration of high-frequency acoustic waves with microfluidics has been gaining popularity as a method of separating cells/particles. A standing surface acoustic wave (sSAW) device produces constructive interference of the stationary waves, demonstrating an increase in cell separating efficiency without damaging/altering the cell structure. The performance of an sSAW device depends on the applied input signal, design of the IDT, and piezoelectric properties of the substrate. This work analyzes the characteristics of a validated 3D finite element model (FEM) of LiNbO3 and the effect on the displacement components of the mechanical waves under the influence of sSAWs by considering XY-, YX-, and 1280 YX-cut LiNbO3 with varying electrode length design. We demonstrated that device performance can be enhanced by the interference of multiple waves under a combination of input signals. The results suggest that 1280 YX-cut LiNbO3 is suitable for generating higher-amplitude out-of-plane waves which can improve the effectiveness of acoustofluidics-based cell separation. Additionally, the findings showed that the length of the electrode impacts the formation of the wavefront significantly. Full article
(This article belongs to the Special Issue Cell Manipulation on a Microfluidic Device)
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