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Optical-Based Sensors and Sensing Technologies for Biomedical Applications

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Optical Sensors".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 4471

Special Issue Editors


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Guest Editor
Department of Chemical Science, University of Catania, Catania, Italy
Interests: supramolecular chemistry; sensing; organic synthesis
Special Issues, Collections and Topics in MDPI journals

E-Mail Website1 Website2
Guest Editor
Department of Chemical Science, University of Catania, Catania, Italy
Interests: fluorescent probes; organic synthesis; stimuli-responsive materials; supramolecular chemistry

Special Issue Information

Dear Colleagues,

Optical sensing through molecular or nanostructured probes is a promising strategy for the detection of a wide range of analytes, affording high sensitivity and a fast readout response. Indeed, compared to instrumental technologies (such as HPLC, NMR, GC), this sensing strategy allows a facile and economic use. In particular, emission-based detection is extremely efficient due to the high sensitivity of the fluorescence technique. The development of fluorescent organic probes, properly functionalized with a receptor moiety, leads to optical sensors able to give a measurable or visible response after the interaction with the sub-ppm concentration of the selected analyte. In particular, today these sensors find applications in the medical field, due to the need to detect a vast range of important analytes involved in many diseases.

The target of this Special Issue is to collect the recent advances in this field (research articles and review), in particular concerning the detection of chemical and biological analytes and having a high impact on human life, including but not limited to transition metals, organic and inorganic pollutants, chemical weapons, neurotransmitters, metabolites, and molecules or biomolecules related to important diseases. Topics of interest include but are not limited to the following:

  • Fluorescent sensors;
  • Optical sensors;
  • Intracellular probes;
  • Metal ions;
  • Metabolites;
  • Covalent sensing;
  • Supramolecular sensing;
  • Smart devices;
  • Medical diagnosis.

Prof. Dr. Giuseppe Trusso Sfrazzetto
Dr. Roberta Puglisi
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fluorescence
  • sensing
  • smart materials
  • medical devices
  • supramolecular sensing
  • covalent sensing
  • reusability

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Published Papers (2 papers)

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Research

22 pages, 2876 KiB  
Article
Photometric Monitoring of Electronic Cigarette Puff Topography
by Keith Kolaczyk and Hao Jiang
Sensors 2023, 23(19), 8220; https://doi.org/10.3390/s23198220 - 2 Oct 2023
Cited by 1 | Viewed by 2371
Abstract
To study and monitor the adverse health consequences of using electronic cigarettes, a user’s puff topography, which are quantification parameters of the user’s vaping habits, plays a central role. In this work, we introduce a topography sensor to measure the mass of total [...] Read more.
To study and monitor the adverse health consequences of using electronic cigarettes, a user’s puff topography, which are quantification parameters of the user’s vaping habits, plays a central role. In this work, we introduce a topography sensor to measure the mass of total particulate matter generated in every puff and to estimate the nicotine yield. The sensor is compact and low-cost, and is integrated into the electronic cigarette device to promptly and conveniently monitor the user’s daily puff topography. The topography sensor is comprised of a photometric sensor and a pressure sensor. The photometric sensor measures the mass concentration of the aerosol, based on scattering of near-infrared light from airborne particles, while the pressure sensor measures the flow rate. The topography sensor was tested under various conditions including a wide range of atomizer power, puff duration, and inhalation pressure. The sensor’s accuracy was validated by comparing the sensor’s readings with reference measurements, and the results matched closely with the trends reported by existing studies on electronic cigarettes. An example application for tracking a user’s puff topography was also demonstrated. Our topography sensor holds great promise in mitigating the health risks of vaping, and in promoting quality control of electronic cigarette products. Full article
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11 pages, 11028 KiB  
Article
Label-Free DNA Detection Using Etched Tilted Bragg Fiber Grating-Based Biosensor
by Abdullah Al Noman, Jitendra Narayan Dash, Md Abdullah Al Maruf, Cheng Xin, Hwa-Yam Tam and Changyuan Yu
Sensors 2023, 23(16), 7019; https://doi.org/10.3390/s23167019 - 8 Aug 2023
Cited by 4 | Viewed by 1443
Abstract
A label-free-based fiber optic biosensor based on etched tilted Bragg fiber grating (TFBG) is proposed and practically demonstrated. Conventional phase mask technic has been utilized to inscribe tilted fiber Bragg grating with a tilt angle of 10°, while the etching has been accomplished [...] Read more.
A label-free-based fiber optic biosensor based on etched tilted Bragg fiber grating (TFBG) is proposed and practically demonstrated. Conventional phase mask technic has been utilized to inscribe tilted fiber Bragg grating with a tilt angle of 10°, while the etching has been accomplished with hydrofluoric acid. A composite of polyethylenimine (PEI)/poly(acrylic acid) (PAA) has been thermally deposited on the etched TFBG, followed by immobilization of probe DNA (pDNA) on this deposited layer. The hybridization of pDNA with the complementary DNA (cDNA) has been monitored using wavelength-dependent interrogation. The reproducibility of the probes has been demonstrated by fabricating three identical probes and their response has been investigated for cDNA concentration ranging from 0 μM to 3 μM. The maximum sensitivity has been found to be 320 pm/μM, with the detection limit being 0.65 μM. Furthermore, the response of the probes towards non-cDNA has also been investigated in order to establish its specificity. Full article
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