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State-of-the-Art Biosensors Technology in China 2020–2021
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State-of-the-Art Biosensors Technology in China 2020–2021

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: closed (15 April 2022) | Viewed by 28425

Special Issue Editors

Prof. Dr. Wei Wang

E-Mail Website
Guest Editor
School of Electrical Engineering and Computer Sciences, Peking University, Beijing 100871, China
Interests: micro/nanofabrication; nanofluidics; liquid biopsy
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Shengyong Xu

E-Mail Website
Guest Editor
School of Electronics, Peking University, Beijing 100871, China
Interests: brain memory and data-processing mechanism; brain–computer interface; artificial vision systems; thermal sensor at micro-/nanoscales
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biosensors are the basic elements of emerging networks for novel health monitor and medical diagnosis of individuals, families, clinics, and hospitals. This Special Issue will provide an overview of the progress and state-of-the-art techniques of manmade biosensors, as well as the latest understandings of the working mechanisms of natural biosensors. Topics include, but are not limited to the following:

  • New sensing mechanisms
  • Key materials for biosensors
  • Fabrication techniques for biosensors
  • Sample preparation techniques for biosensors
  • Biosensor networks
  • Artificial intelligent assisted biosensors
  • Clinical biosensors
  • Wearable biosensors
  • Implantable biosensors
  • Legal and ethical issues of biosensors

Prof. Wei Wang
Prof. Shengyong Xu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Artificial biosensors
  • Natural biosensors
  • Sensing mechanisms
  • Biomedical sensors
  • Wearable sensors
  • NEMS/MEMS

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (6 papers)

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Research

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10 pages, 3614 KiB  
Article
Fabrication and Characterization of Iridium Oxide pH Microelectrodes Based on Sputter Deposition Method
by Ye Xi, Zhejun Guo, Longchun Wang, Qingda Xu, Tao Ruan and Jingquan Liu
Sensors 2021, 21(15), 4996; https://doi.org/10.3390/s21154996 - 23 Jul 2021
Cited by 6 | Viewed by 2995
Abstract
pH value plays an important role in many fields such as chemistry and biology; therefore, rapid and accurate pH measurement is very important. Because of its advantages in preparation, wide test range, rapid response, and good biocompatibility, iridium oxide material has received more [...] Read more.
pH value plays an important role in many fields such as chemistry and biology; therefore, rapid and accurate pH measurement is very important. Because of its advantages in preparation, wide test range, rapid response, and good biocompatibility, iridium oxide material has received more and more attention. In this paper, we present a method for preparing iridium oxide pH microelectrodes based on the sputter deposition method. The sputtering parameters of iridium oxide are also studied and optimized. Open-circuit potential tests show that microelectrodes exhibit near-Nernstian pH response with good linearity (about 60 mV/pH), fast response, high stability (a slight periodic fluctuation of potential change <2.5 mV in 24 h), and good reversibility in the pH range of 1.00–13.00. Full article
(This article belongs to the Special Issue State-of-the-Art Biosensors Technology in China 2020–2021)
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11 pages, 2192 KiB  
Communication
An Electrochemical Ti3C2Tx Aptasensor for Sensitive and Label-Free Detection of Marine Biological Toxins
by Najeeb Ullah, Wei Chen, Beenish Noureen, Yulan Tian, Liping Du, Chunsheng Wu and Jie Ma
Sensors 2021, 21(14), 4938; https://doi.org/10.3390/s21144938 - 20 Jul 2021
Cited by 24 | Viewed by 3291
Abstract
Saxitoxin (STX) belongs to the family of marine biological toxins, which are major contaminants in seafood. The reference methods for STX detection are mouse bioassay and chromatographic analysis, which are time-consuming, high costs, and requirement of sophisticated operation. Therefore, the development of alternative [...] Read more.
Saxitoxin (STX) belongs to the family of marine biological toxins, which are major contaminants in seafood. The reference methods for STX detection are mouse bioassay and chromatographic analysis, which are time-consuming, high costs, and requirement of sophisticated operation. Therefore, the development of alternative methods for STX analysis is urgent. Electrochemical analysis is a fast, low-cost, and sensitive method for biomolecules analysis. Thus, in this study, an electrolyte-insulator-semiconductor (EIS) sensor based on aptamer-modified two-dimensional layered Ti3C2Tx nanosheets was developed for STX detection. The high surface area and rich functional groups of MXene benefited the modification of aptamer, which had specific interactions with STX. Capacitance-voltage (C-V) and constant-capacitance (ConCap) measurement results indicated that the aptasensor was able to detect STX with high sensitivity and good specificity. The detection range was 1.0 nM to 200 nM and detection limit was as low as 0.03 nM. Moreover, the aptasensor was found to have a good selectivity and two-week stability. The mussel tissue extraction test suggested the potential application of this biosensor in detecting STX in real samples. This method provides a convenient approach for low-cost, rapid, and label-free detection of marine biological toxins. Full article
(This article belongs to the Special Issue State-of-the-Art Biosensors Technology in China 2020–2021)
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12 pages, 6549 KiB  
Communication
A Flexible Integrated Bending Strain and Pressure Sensor System for Motion Monitoring
by Rou Feng, Yifeng Mu, Xiangwen Zeng, Weijie Jia, Yuxuan Liu, Xijun Jiang, Qibei Gong and Youfan Hu
Sensors 2021, 21(12), 3969; https://doi.org/10.3390/s21123969 - 9 Jun 2021
Cited by 24 | Viewed by 5628
Abstract
Flexible sensors have attracted increasing research interest due to their broad application potential in the fields of human–computer interaction, medical care, sports monitoring, etc. Constructing an integrated sensor system with high performance and being capable of discriminating different stimuli remains a challenge. Here, [...] Read more.
Flexible sensors have attracted increasing research interest due to their broad application potential in the fields of human–computer interaction, medical care, sports monitoring, etc. Constructing an integrated sensor system with high performance and being capable of discriminating different stimuli remains a challenge. Here, we proposed a flexible integrated sensor system for motion monitoring that can measure bending strain and pressure independently with a low-cost and simple fabrication process. The resistive bending strain sensor in the system is fabricated by sintering polyimide (PI), demonstrating a gauge factor of 9.54 and good mechanical stability, while the resistive pressure sensor is constructed based on a composite structure of silver nanowires (AgNWs) and polydimethylsiloxane (PDMS)-expandable microspheres with a tunable sensitivity and working range. Action recognition is demonstrated by attaching the flexible integrated sensor system on the wrist with independent strain and pressure information recorded from corresponding sensors. It shows a great application potential in motion monitoring and intelligent human–machine interfaces. Full article
(This article belongs to the Special Issue State-of-the-Art Biosensors Technology in China 2020–2021)
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16 pages, 4125 KiB  
Article
A Flexible PI/Si/SiO2 Piezoresistive Microcantilever for Trace-Level Detection of Aflatoxin B1
by Yuan Tian, Yi Liu, Yang Wang, Jia Xu and Xiaomei Yu
Sensors 2021, 21(4), 1118; https://doi.org/10.3390/s21041118 - 5 Feb 2021
Cited by 6 | Viewed by 3061
Abstract
In this paper, a polyimide (PI)/Si/SiO2-based piezoresistive microcantilever biosensor was developed to achieve a trace level detection for aflatoxin B1. To take advantage of both the high piezoresistance coefficient of single-crystal silicon and the small spring constant of PI, the flexible [...] Read more.
In this paper, a polyimide (PI)/Si/SiO2-based piezoresistive microcantilever biosensor was developed to achieve a trace level detection for aflatoxin B1. To take advantage of both the high piezoresistance coefficient of single-crystal silicon and the small spring constant of PI, the flexible piezoresistive microcantilever was designed using the buried oxide (BOX) layer of a silicon-on-insulator (SOI) wafer as a bottom passivation layer, the topmost single-crystal silicon layer as a piezoresistor layer, and a thin PI film as a top passivation layer. To obtain higher sensitivity and output voltage stability, four identical piezoresistors, two of which were located in the substrate and two integrated in the microcantilevers, were composed of a quarter-bridge configuration wheatstone bridge. The fabricated PI/Si/SiO2 microcantilever showed good mechanical properties with a spring constant of 21.31 nN/μm and a deflection sensitivity of 3.54 × 10−7 nm−1. The microcantilever biosensor also showed a stable voltage output in the Phosphate Buffered Saline (PBS) buffer with a fluctuation less than 1 μV @ 3 V. By functionalizing anti-aflatoxin B1 on the sensing piezoresistive microcantilever with a biotin avidin system (BAS), a linear aflatoxin B1 detection concentration resulting from 1 ng/mL to 100 ng/mL was obtained, and the toxic molecule detection also showed good specificity. The experimental results indicate that the PI/Si/SiO2 flexible piezoresistive microcantilever biosensor has excellent abilities in trace-level and specific detections of aflatoxin B1 and other biomolecules. Full article
(This article belongs to the Special Issue State-of-the-Art Biosensors Technology in China 2020–2021)
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Review

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13 pages, 2712 KiB  
Review
Thermal Probing Techniques for a Single Live Cell
by Nana Yang, Jingjing Xu, Fan Wang, Fan Yang, Danhong Han and Shengyong Xu
Sensors 2022, 22(14), 5093; https://doi.org/10.3390/s22145093 - 7 Jul 2022
Cited by 4 | Viewed by 2378
Abstract
Temperature is a significant factor in determining and characterizing cellular metabolism and other biochemical activities. In this study, we provide a brief overview of two important technologies used to monitor the local temperatures of individual living cells: fluorescence nano-thermometry and an array of [...] Read more.
Temperature is a significant factor in determining and characterizing cellular metabolism and other biochemical activities. In this study, we provide a brief overview of two important technologies used to monitor the local temperatures of individual living cells: fluorescence nano-thermometry and an array of micro-/nano-sized thin-film thermocouples. We explain some key technical issues that must be addressed and optimised for further practical applications, such as in cell biology, drug selection, and novel antitumor therapy. We also offer a method for combining them into a hybrid measuring system. Full article
(This article belongs to the Special Issue State-of-the-Art Biosensors Technology in China 2020–2021)
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18 pages, 3429 KiB  
Review
Carbon Nanotube Field-Effect Transistor-Based Chemical and Biological Sensors
by Xuesong Yao, Yalei Zhang, Wanlin Jin, Youfan Hu and Yue Cui
Sensors 2021, 21(3), 995; https://doi.org/10.3390/s21030995 - 2 Feb 2021
Cited by 53 | Viewed by 9569
Abstract
Chemical and biological sensors have attracted great interest due to their importance in applications of healthcare, food quality monitoring, environmental monitoring, etc. Carbon nanotube (CNT)-based field-effect transistors (FETs) are novel sensing device configurations and are very promising for their potential to drive many [...] Read more.
Chemical and biological sensors have attracted great interest due to their importance in applications of healthcare, food quality monitoring, environmental monitoring, etc. Carbon nanotube (CNT)-based field-effect transistors (FETs) are novel sensing device configurations and are very promising for their potential to drive many technological advancements in this field due to the extraordinary electrical properties of CNTs. This review focuses on the implementation of CNT-based FETs (CNTFETs) in chemical and biological sensors. It begins with the introduction of properties, and surface functionalization of CNTs for sensing. Then, configurations and sensing mechanisms for CNT FETs are introduced. Next, recent progresses of CNTFET-based chemical sensors, and biological sensors are summarized. Finally, we end the review with an overview about the current application status and the remaining challenges for the CNTFET-based chemical and biological sensors. Full article
(This article belongs to the Special Issue State-of-the-Art Biosensors Technology in China 2020–2021)
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