Electrochemical Nanosensors for Analysis of Pharmaceuticals
A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Sensor Materials".
Deadline for manuscript submissions: closed (1 March 2022) | Viewed by 6541
Special Issue Editor
Interests: pharmaceutical analysis; electroanalytical methods; nanosensors; modified electrodes; capillary electrophoresis; chromatography; bioactive compounds
Special Issue Information
Dear Colleagues,
The development of novel electrochemical nanosensors and associated sensing approaches is one of the most captivating topics in modern pharmaceutical analysis. Different nanomaterials offer almost unlimited possibilities for new sensor platform designs to address the growing needs for enhanced sensitivity, selectivity, rapid response, reliable measuring in untreated samples, on-site testing, and miniaturization of sensing elements. Electrochemical nanosensors cover a large domain of investigation in pharmaceutical analysis ranging from the determination of active pharmaceutical ingredients in pharmaceutical dosage forms ensuring safety, efficacy, and high quality of medicines, as well as in biological samples to obtain effective therapy and prevent overdose-induced toxicity. The monitoring of therapeutic drug concentration is a critical subject in clinical and pharmacokinetic studies and important component of personalized medicine. Furthermore, electrochemical nanosensors can be used at the early stage of drug research to screen the activity of newly synthesized molecules due to correlations noted between redox potential and pharmacological activity. Electron transfer reactions play an important role in understanding the mechanism of action of various drugs and can serve as a useful tool in the design of more active and safer pharmaceuticals. The knowlage of redox properties of drugs can give insights into their metabolic fate or in vivo redox processes. Nanomaterial-based sensors have applications in drug–protein binding and drug–DNA interaction studies, giving results which are useful in drug bioavailability and toxicity tests.
Electrochemical nanosensors are a rapidly growing research area in pharmaceutical sciences. Nanomaterials such as nanotubes, nanofibers, nanowires, nanoparticles, quantum dots, fullerene, graphene, and nanodiamonds have recently found a wide range of interesting pharmaceutical and biomedical applications. They are very attractive in the field of sensor development due to their unique characteristics and advantageous properties for electroanalysis, such as enhanced electronic properties, high electrical conductivity, excellent chemical stability, and high surface-to-volume ratio. To improve the selectivity of nanomaterials to target drug molecules as well as their adsorption capacity related to enhanced sensitivity, various functionalization strategies can be applied for the fabrication of novel sensors. Electrochemical nanosensors have lower detection limits for pharmaceuticals, excellent electrocatalytic properties, good reproducibility, and limited access of interferences in a complex samples when compared with other sensors.
The aim of this Special Issue is to publish original research articles and reviews that cover recent advances in the application of electrochemical nanosensors for investigation and analysis of pharmaceuticals and pharmacologically active molecules.
Prof. Dr. Biljana Nigovic
Guest Editor
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Keywords
- carbon nanotubes
- graphene
- nanoparticles
- nanocomposites
- electrochemical sensor design
- electroanalysis
- pharmaceutical analysis
- biomedical applications
- biological samples
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