Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.3
3.4
Journals
Sensors
Special Issues
Innovative Strategy of MIP Sensors on the Road to Practical...
sensors-logo
Submit to Sensors Review for Sensors Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Innovative Strategy of MIP Sensors on the Road to Practical Applications

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Chemical Sensors".

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 24990

Special Issue Editors

Prof. Dr. Yasuo Yoshimi

E-Mail Website
Guest Editor
Department Applied Chemistry, Shibaura Institute of Technology, Toyosu, Koto-City, Tokyo 135-8548, Japan
Interests: gate effect; graft polymerisation; therapeutic drug monitoring; neuroimaging
Prof. Dr. Sergey A Piletsky

E-Mail Website
Guest Editor
Department of Chemistry, University of Leicester, Leicester LE1 7RH, UK
Interests: biomimetic molecularly imprinted polymers (MIPs); computational design and molecular modelling; bioanalytical chemistry; nanoparticles for diagnostics and therapeutic applications

Special Issue Information

Dear Colleagues,

Molecularly imprinted polymers (MIPs) are synthetic receptors with affinity which is generated by self-assembling of functional monomers around a template. MIP can be obtained by a simpler and more economic procedure than enzymes or antibodies which requires use of animals and a complex purification process. Thus, MIPs are feasible tool for selective, robust, and economic biomimetic sensors which will supersede traditional enzymatic biosensors and immunosensors. However, a methodology for generating optical or electric signal triggered by interaction between the MIP and template has to be developed because MIP usually does not have catalytic properties, like enzymes. Recent developments in MIP technology have addressed this issue, allowing for first time the creation of sensor devices which can potentially compete with commercial sensors.

This Special Issue expects papers, communications, and reviews reporting and discussing innovative research for applications of MIPS for sensors, specifically:

  • New strategies for transducing specific interaction into electrical and optical signals;
  • Development of MIP sensors for practical applications;
  • Analysis of patents related to the development of MIP sensors.

Prof. Dr. Yasuo Yoshimi
Prof. Dr. Sergey A Piletsky
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Molecularly imprinted polymer (MIP)
  • Chemical or physical properties of MIPs
  • Transducing methodology 
  • Sensing mechanism in MIP systems
  • New applications

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (5 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

14 pages, 6624 KiB  
Article
Reagentless Sensing of Vancomycin Using an Indium Tin Oxide Electrode Grafted with Molecularly Imprinted Polymer including Ferrocenyl Group
by Haruto Eguchi, Akihiko Hatano and Yasuo Yoshimi
Sensors 2021, 21(24), 8338; https://doi.org/10.3390/s21248338 - 13 Dec 2021
Cited by 3 | Viewed by 2873
Abstract
Vancomycin (VCM) is a first-line antimicrobial agent against methicillin-resistant Staphylococcus aureus, a cause of nosocomial infections. Therapeutic drug monitoring is strongly recommended for VCM-based chemotherapy. The authors attempted to develop a simple VCM sensor based on molecularly imprinted polymer (MIP), which can be [...] Read more.
Vancomycin (VCM) is a first-line antimicrobial agent against methicillin-resistant Staphylococcus aureus, a cause of nosocomial infections. Therapeutic drug monitoring is strongly recommended for VCM-based chemotherapy. The authors attempted to develop a simple VCM sensor based on molecularly imprinted polymer (MIP), which can be used with simple operations. Methacrylic acid (MAA), acrylamide, methylenebisacrylamide, and allylamine carboxypropionate-3-ferrocene (ACPF) were copolymerized in the presence of VCM and grafted from the surface of indium-tin oxide (ITO) to obtain MIP-coated electrodes. The MIP-grafted ITO electrode was used for differential pulse voltammetry (DPV) measurements in a buffer solution containing VCM or whole bovine blood. The obtained current depends on the VCM concentration with high linearity. The dynamic range covered the therapeutic range (20–40 μg/mL) of the VCM but was almost insensitive to teicoplanin, which has a similar structure to VCM. The ITO electrodes grafted by the same procedure except for omitting either VCM or APCF were not sensitive to VCM. The sensitivity of the MIP electrodes to VCM in whole blood and buffered saline, but the background current in blood was higher than that in saline. This high background current was also seen in the deproteinized plasma. Thus, the current is probably originated from the oxidation of low molecular weight reducing agents in the blood. The MIP-grafted ITO electrode using ACPF as a functional monomer would be a promising highly selective sensor for real-time monitoring of VCM with proper correction of the background current. Full article
(This article belongs to the Special Issue Innovative Strategy of MIP Sensors on the Road to Practical Applications)
►▼ Show Figures

Figure 1

17 pages, 6193 KiB  
Article
A “Single-Use” Ceramic-Based Electrochemical Sensor Chip Using Molecularly Imprinted Carbon Paste Electrode
by Aaryashree, Yuuto Takeda, Momoe Kanai, Akihiko Hatano, Yasuo Yoshimi and Masahito Kida
Sensors 2020, 20(20), 5847; https://doi.org/10.3390/s20205847 - 16 Oct 2020
Cited by 16 | Viewed by 3920
Abstract
An inexpensive disposable electrochemical drug sensor for the detection of drugs (vancomycin, meropenem, theophylline, and phenobarbital) is described. Molecularly imprinted polymer (MIP) templated with the target drugs was immobilized on the surface of graphite particles using a simple radical polymerization method and packed [...] Read more.
An inexpensive disposable electrochemical drug sensor for the detection of drugs (vancomycin, meropenem, theophylline, and phenobarbital) is described. Molecularly imprinted polymer (MIP) templated with the target drugs was immobilized on the surface of graphite particles using a simple radical polymerization method and packed into the working electrode of a three-electrode ceramic-based chip sensor. Differential pulse voltammetry (DPV) was used to determine the relationship between the response current and the concentration of the targeted drug while using one sensor chip for one single operation. The time required for each DPV measurement was less than 2 min. Concentrations corresponding to the therapeutic range of these drugs in plasma were taken into account while performing DPV. In all the cases, the single-used MIP sensor showed higher sensitivity and linearity than non-imprinted polymer. The selectivity test in drugs with a structure similar to that of the target drugs was performed, and it was found that MIP-based sensors were more selective than the untreated ones. Additionally, the test in whole blood showed that the presence of interfering species had an insignificant effect on the diagnostic responses of the sensor. These results demonstrate that the disposable MIP-sensor is promising for quick and straightforward therapeutic drug monitoring to prevent the toxic side effects and the insufficient therapeutic effect due to the overdose and underdose, respectively. Full article
(This article belongs to the Special Issue Innovative Strategy of MIP Sensors on the Road to Practical Applications)
►▼ Show Figures

Graphical abstract

20 pages, 2050 KiB  
Article
Sensor Based on Molecularly Imprinted Polymer Membranes and Smartphone for Detection of Fusarium Contamination in Cereals
by Tetyana Sergeyeva, Daria Yarynka, Larysa Dubey, Igor Dubey, Elena Piletska, Rostyslav Linnik, Maksym Antonyuk, Tamara Ternovska, Oleksandr Brovko, Sergey Piletsky and Anna El’skaya
Sensors 2020, 20(15), 4304; https://doi.org/10.3390/s20154304 - 1 Aug 2020
Cited by 35 | Viewed by 4006
Abstract
The combination of the generic mobile technology and inherent stability, versatility and cost-effectiveness of the synthetic receptors allows producing optical sensors for potentially any analyte of interest, and, therefore, to qualify as a platform technology for a fast routine analysis of a large [...] Read more.
The combination of the generic mobile technology and inherent stability, versatility and cost-effectiveness of the synthetic receptors allows producing optical sensors for potentially any analyte of interest, and, therefore, to qualify as a platform technology for a fast routine analysis of a large number of contaminated samples. To support this statement, we present here a novel miniature sensor based on a combination of molecularly imprinted polymer (MIP) membranes and a smartphone, which could be used for the point-of-care detection of an important food contaminant, oestrogen-like toxin zearalenone associated with Fusarium contamination of cereals. The detection is based on registration of natural fluorescence of zearalenone using a digital smartphone camera after it binds to the sensor recognition element. The recorded image is further processed using a mobile application. It shows here a first example of the zearalenone-specific MIP membranes synthesised in situ using “dummy template”-based approach with cyclododecyl 2, 4-dihydroxybenzoate as the template and 1-allylpiperazine as a functional monomer. The novel smartphone sensor system based on optimized MIP membranes provides zearalenone detection in cereal samples within the range of 1–10 µg mL−1 demonstrating a detection limit of 1 µg mL−1 in a direct sensing mode. In order to reach the level of sensitivity required for practical application, a competitive sensing mode is also developed. It is based on application of a highly-fluorescent structural analogue of zearalenone (2-[(pyrene-l-carbonyl) amino]ethyl 2,4-dihydroxybenzoate) which is capable to compete with the target mycotoxin for the binding to zearalenone-selective sites in the membrane’s structure. The competitive mode increases 100 times the sensor’s sensitivity and allows detecting zearalenone at 10 ng mL−1. The linear dynamic range in this case comprised 10–100 ng mL−1. The sensor system is tested and found effective for zearalenone detection in maize, wheat and rye flour samples both spiked and naturally contaminated. The developed MIP membrane-based smartphone sensor system is an example of a novel, inexpensive tool for food quality analysis, which is portable and can be used for the “field” measurements and easily translated into the practice. Full article
(This article belongs to the Special Issue Innovative Strategy of MIP Sensors on the Road to Practical Applications)
►▼ Show Figures

Graphical abstract

Review

Jump to: Research

23 pages, 2826 KiB  
Review
Molecular Imprinted Polymers Coupled to Photonic Structures in Biosensors: The State of Art
by Andrea Chiappini, Laura Pasquardini and Alessandra Maria Bossi
Sensors 2020, 20(18), 5069; https://doi.org/10.3390/s20185069 - 7 Sep 2020
Cited by 40 | Viewed by 5335
Abstract
Optical sensing, taking advantage of the variety of available optical structures, is a rapidly expanding area. Over recent years, whispering gallery mode resonators, photonic crystals, optical waveguides, optical fibers and surface plasmon resonance have been exploited to devise different optical sensing configurations. In [...] Read more.
Optical sensing, taking advantage of the variety of available optical structures, is a rapidly expanding area. Over recent years, whispering gallery mode resonators, photonic crystals, optical waveguides, optical fibers and surface plasmon resonance have been exploited to devise different optical sensing configurations. In the present review, we report on the state of the art of optical sensing devices based on the aforementioned optical structures and on synthetic receptors prepared by means of the molecular imprinting technology. Molecularly imprinted polymers (MIPs) are polymeric receptors, cheap and robust, with high affinity and selectivity, prepared by a template assisted synthesis. The state of the art of the MIP functionalized optical structures is critically discussed, highlighting the key progresses that enabled the achievement of improved sensing performances, the merits and the limits both in MIP synthetic strategies and in MIP coupling. Full article
(This article belongs to the Special Issue Innovative Strategy of MIP Sensors on the Road to Practical Applications)
►▼ Show Figures

Figure 1

23 pages, 3702 KiB  
Review
How Reliable Is the Electrochemical Readout of MIP Sensors?
by Aysu Yarman and Frieder W. Scheller
Sensors 2020, 20(9), 2677; https://doi.org/10.3390/s20092677 - 8 May 2020
Cited by 60 | Viewed by 6870
Abstract
Electrochemical methods offer the simple characterization of the synthesis of molecularly imprinted polymers (MIPs) and the readouts of target binding. The binding of electroinactive analytes can be detected indirectly by their modulating effect on the diffusional permeability of a redox marker through thin [...] Read more.
Electrochemical methods offer the simple characterization of the synthesis of molecularly imprinted polymers (MIPs) and the readouts of target binding. The binding of electroinactive analytes can be detected indirectly by their modulating effect on the diffusional permeability of a redox marker through thin MIP films. However, this process generates an overall signal, which may include nonspecific interactions with the nonimprinted surface and adsorption at the electrode surface in addition to (specific) binding to the cavities. Redox-active low-molecular-weight targets and metalloproteins enable a more specific direct quantification of their binding to MIPs by measuring the faradaic current. The in situ characterization of enzymes, MIP-based mimics of redox enzymes or enzyme-labeled targets, is based on the indication of an electroactive product. This approach allows the determination of both the activity of the bio(mimetic) catalyst and of the substrate concentration. Full article
(This article belongs to the Special Issue Innovative Strategy of MIP Sensors on the Road to Practical Applications)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-5
Back to TopTop