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Paper-Based Biosensing Platforms
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Paper-Based Biosensing Platforms

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Chemical Sensors".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 9720

Special Issue Editors

Dr. Felismina Teixeira Coelho Moreira

E-Mail Website
Guest Editor
BioMark@ISEP, School of Engineering, Polytechnique School of Porto, 4200-072 Porto, Portugal
Interests: biosensor; electrochemical sensor; plastic antibody
Special Issues, Collections and Topics in MDPI journals
Dr. Gabriela Martins

E-Mail Website
Guest Editor
BioMark@ISEP, School of Engineering, Polytechnique School of Porto, 4200-072 Porto, Portugal
Interests: biosensor; electrochemistry; molecularly-imprinted polymer

Special Issue Information

Dear Colleagues,

Cellulose is one of the most abundant biopolymers on earth. It offers advantages such as portability, sensitivity, specificity, ease of use and device independence without compromising affordability. Due to the physical and chemical flexibility of cellulose, these types of devices can be architecturally modified indefinitely, making them very attractive for biosensor applications.

In addition, cellulose-based biosensors can meet the World Health Organization’s criteria ASSURED (affordable, sensitive, specific, user-friendly, fast and robust, device-free and available to the end-user) for ideal diagnostic tests/devices. Cellulose thus offers excellent materials to the biosensing community for the development of innovative analytical devices.

This Special Issue focuses on innovative approaches that address the design, fabrication and advantageous analytical performance of paper-based biosensor platforms. Applications may include medical/clinical diagnostics, healthcare, point-of-care testing, environmental monitoring, food analysis or other biochemical and biological analyses.

Dr. Felismina Teixeira Coelho Moreira
Dr. Gabriela Martins
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biosensors
  • cellulose-based microfluidics
  • nanocomposite materials
  • nanocellulose
  • paper-based analytical devices
  • photolithography
  • point-of-care
  • portable devices
  • diagnostics
  • environmental monitoring
  • food analysis
  • health care
  • lateral flow immunoassay
  • micro/nanocellulose fibrils
  • multiplexed detection

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Published Papers (2 papers)

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10 pages, 1890 KiB  
Article
Simple and Sensitive Detection of Bacterial Hydrogen Sulfide Production Using a Paper-Based Colorimetric Assay
by Byung-Ki Ahn, Yong-Jin Ahn, Young-Ju Lee, Yeon-Hee Lee and Gi-Ja Lee
Sensors 2022, 22(15), 5928; https://doi.org/10.3390/s22155928 - 8 Aug 2022
Cited by 7 | Viewed by 3054
Abstract
Hydrogen sulfide (H2S) is known to participate in bacteria-induced inflammatory response in periodontal diseases. Therefore, it is necessary to quantify H2S produced by oral bacteria for diagnosis and treatment of oral diseases including halitosis and periodontal disease. In this [...] Read more.
Hydrogen sulfide (H2S) is known to participate in bacteria-induced inflammatory response in periodontal diseases. Therefore, it is necessary to quantify H2S produced by oral bacteria for diagnosis and treatment of oral diseases including halitosis and periodontal disease. In this study, we introduce a paper-based colorimetric assay for detecting bacterial H2S utilizing silver/Nafion/polyvinylpyrrolidone membrane and a 96-well microplate. This H2S-sensing paper showed a good sensitivity (8.27 blue channel intensity/μM H2S, R2 = 0.9996), which was higher than that of lead acetate paper (6.05 blue channel intensity/μM H2S, R2 = 0.9959). We analyzed the difference in H2S concentration released from four kinds of oral bacteria (Eikenella corrodens, Streptococcus sobrinus, Streptococcus mutans, and Lactobacillus casei). Finally, the H2S level in Eikenella corrodens while varying the concentration of cysteine and treatment time was quantified. This paper-based colorimetric assay can be utilized as a simple and effective tool for in vitro screening of H2S-producing ability of many bacteria as well as salivary H2S analysis. Full article
(This article belongs to the Special Issue Paper-Based Biosensing Platforms)
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Review

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26 pages, 5275 KiB  
Review
Colorimetric Paper-Based Sensors against Cancer Biomarkers
by Mariana C. C. G. Carneiro, Ligia R. Rodrigues, Felismina T. C. Moreira and Maria Goreti F. Sales
Sensors 2022, 22(9), 3221; https://doi.org/10.3390/s22093221 - 22 Apr 2022
Cited by 27 | Viewed by 5987
Abstract
Cancer is a major cause of mortality and morbidity worldwide. Detection and quantification of cancer biomarkers plays a critical role in cancer early diagnosis, screening, and treatment. Clinicians, particularly in developing countries, deal with high costs and limited resources for diagnostic systems. Using [...] Read more.
Cancer is a major cause of mortality and morbidity worldwide. Detection and quantification of cancer biomarkers plays a critical role in cancer early diagnosis, screening, and treatment. Clinicians, particularly in developing countries, deal with high costs and limited resources for diagnostic systems. Using low-cost substrates to develop sensor devices could be very helpful. The interest in paper-based sensors with colorimetric detection increased exponentially in the last decade as they meet the criteria for point-of-care (PoC) devices. Cellulose and different nanomaterials have been used as substrate and colorimetric probes, respectively, for these types of devices in their different designs as spot tests, lateral-flow assays, dipsticks, and microfluidic paper-based devices (μPADs), offering low-cost and disposable devices. However, the main challenge with these devices is their low sensitivity and lack of efficiency in performing quantitative measurements. This review includes an overview of the use of paper for the development of sensing devices focusing on colorimetric detection and their application to cancer biomarkers. We highlight recent works reporting the use of paper in the development of colorimetric sensors for cancer biomarkers, such as proteins, nucleic acids, and others. Finally, we discuss the main advantages of these types of devices and highlight their major pitfalls. Full article
(This article belongs to the Special Issue Paper-Based Biosensing Platforms)
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