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Advanced Photonic Biosensors
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Advanced Photonic Biosensors

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: closed (31 March 2020) | Viewed by 11044

Special Issue Editor

Dr. Amadeu Griol

E-Mail Website
Guest Editor
Nanophotonics Technology Center, Universitat Politècnica de València, Camí de Vera s/n, 46022 Valencia, Spain
Interests: photonics; biosensors; nanotechnology; nanofabrication
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The next generation of bio sensor systems must ensure the convergence of micro/nano, bio, and ICT technologies to achieve smaller, faster, and cheaper devices that perform better while still delivering highly reproducible results, exhibiting increased sensitivity, and being extremely reliable. In this scenario, photonic biosensors present several advantages compared to other sensing technologies, such as their compactness and high integration level, their high sensitivities, high interaction between the optical field and target analytes, shorter times to result or the requirement of very low volumes to perform the sensing. In this sense, the photonic sensing research field has quickly evolved in recent years, going from traditional bulk technologies to integrated photonics with an advanced performance, enhanced functionalities, increased reliability, and reduced costs.

The aim of this Special Issue is to discuss the various types of photonic biosensors, based on different configurations and materials. Contributions can cover different aspects in terms of design, manufacturing, experimental testing, the application of new photonic devices, structures, functional materials, measurement methods, and signal processing, as well as their integration with biotechnology concepts to perform high-quality sensing (DNA, protein, cell detection, etc.).

Applications may cover many areas, ranging from new concepts still experienced in laboratories to sensing systems to be made available on the market, even in highly differentiated sectors, such as biosensing, pharmaceutical and food sensing, environmental sensing, gas sensing, automotive, security, defense, space, and so on.

Dr. Amadeu Griol
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Photonics 
  • Photonic sensors 
  • Biotechnology 
  • Whispering gallery mode resonators
  • Mach–Zehnder interferometers 
  • Surface plasmon resonance biosensor 
  • Photonic crystals biosensors
  • Optical fiber biosensors 
  • Bio functionalization 
  • Antibodies and antibody-derived biosensors 
  • Aptamer-based biosensors 
  • DNA/RNA-based biosensors
  • Molecular beacon biosensors

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Published Papers (3 papers)

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Research

10 pages, 2550 KiB  
Article
Quantification of Neuropeptide Y with Picomolar Sensitivity Enabled by Guided-Mode Resonance Biosensors
by Mohammad G. Abdallah, Joseph A. Buchanan-Vega, Kyu J. Lee, Brett R. Wenner, Jeffery W. Allen, Monica S. Allen, Susanne Gimlin, Debra Wawro Weidanz and Robert Magnusson
Sensors 2020, 20(1), 126; https://doi.org/10.3390/s20010126 - 24 Dec 2019
Cited by 26 | Viewed by 4256
Abstract
Assessing levels of neuropeptide Y (NPY) in the human body has many medical uses. Accordingly, we report the quantitative detection of NPY biomarkers applying guided-mode resonance (GMR) biosensor methodology. The label-free sensor operates in the near-infrared spectral region exhibiting distinctive resonance signatures. The [...] Read more.
Assessing levels of neuropeptide Y (NPY) in the human body has many medical uses. Accordingly, we report the quantitative detection of NPY biomarkers applying guided-mode resonance (GMR) biosensor methodology. The label-free sensor operates in the near-infrared spectral region exhibiting distinctive resonance signatures. The interaction of NPY with bioselective molecules on the sensor surface causes spectral shifts that directly identify the binding event without additional processing. In the experiments described here, NPY antibodies are attached to the sensor surface to impart specificity during operation. For the low concentrations of NPY of interest, we apply a sandwich NPY assay in which the sensor-linked anti-NPY molecule binds with NPY that subsequently binds with anti-NPY to close the sandwich. The sandwich assay achieves a detection limit of ~0.1 pM NPY. The photonic sensor methodology applied here enables expeditious high-throughput data acquisition with high sensitivity and specificity. The entire bioreaction is recorded as a function of time, in contrast to label-based methods with single-point detection. The convenient methodology and results reported are significant, as the NPY detection range of 0.1–10 pM demonstrated is useful in important medical circumstances. Full article
(This article belongs to the Special Issue Advanced Photonic Biosensors)
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11 pages, 3821 KiB  
Article
Design and Development of Photonic Biosensors for Swine Viral Diseases Detection
by Amadeu Griol, Sergio Peransi, Manuel Rodrigo, Juan Hurtado, Laurent Bellieres, Teodora Ivanova, David Zurita, Carles Sánchez, Sara Recuero, Alejandro Hernández, Santiago Simón, Gyula Balka, Ioannis Bossis, Alessandro Capo, Alessandra Camarca, Sabato D’Auria, Antonio Varriale and Alessandro Giusti
Sensors 2019, 19(18), 3985; https://doi.org/10.3390/s19183985 - 15 Sep 2019
Cited by 12 | Viewed by 3527
Abstract
In this paper we introduce a field diagnostic device based on the combination of advanced bio-sensing and photonics technologies, to tackle emerging and endemic viruses causing swine epidemics, and consequently significant economic damage in farms. The device is based on the use of [...] Read more.
In this paper we introduce a field diagnostic device based on the combination of advanced bio-sensing and photonics technologies, to tackle emerging and endemic viruses causing swine epidemics, and consequently significant economic damage in farms. The device is based on the use of microring resonators fabricated in silicon nitride with CMOS compatible techniques. In the paper, the designed and fabricated photonic integrated circuit (PIC) sensors are presented and characterized, showing an optimized performance in terms of optical losses (30 dB per ring) and extinction ration for ring resonances (15 dB). Furthermore, the results of an experiment for porcine circovirus 2 (PCV2) detection by using the developed biosensors are presented. Positive detection for different virus concentrations has been obtained. The device is currently under development in the framework of the EU Commission co-funded project SWINOSTICS. Full article
(This article belongs to the Special Issue Advanced Photonic Biosensors)
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10 pages, 3832 KiB  
Article
Stabilization of Polymeric Nanofibers Layers for Use as Real-Time and In-Flow Photonic Sensors
by Salvador Ponce-Alcántara, Paula Martínez-Pérez, Ana Pérez-Márquez, Jon Maudes, Nieves Murillo and Jaime García-Rupérez
Sensors 2019, 19(18), 3847; https://doi.org/10.3390/s19183847 - 6 Sep 2019
Cited by 2 | Viewed by 2455
Abstract
In order to increase the sensitivity of a sensor, the relationship between its volume and the surface available to be functionalized is of great importance. Accordingly, porous materials are becoming very relevant, because they have a notable surface-to-volume ratio. Moreover, they offer the [...] Read more.
In order to increase the sensitivity of a sensor, the relationship between its volume and the surface available to be functionalized is of great importance. Accordingly, porous materials are becoming very relevant, because they have a notable surface-to-volume ratio. Moreover, they offer the possibility to infiltrate the target substances on them. Among other porous structures, polymeric nanofibers (NFs) layers fabricated by electrospinning have emerged as a very promising alternative to low-cost and easy-to-produce high-performance photonic sensors. However, experimental results show a spectrum drift when performing sensing measurements in real-time. That drift is responsible for a significant error when trying to determine the refractive index variation for a target solution, and, because of that, for the detection of the presence of certain analytes. In order to avoid that problem, different chemical and thermal treatments were studied. The best results were obtained for thermal steps at 190 °C during times between 3 and 5 h. As a result, spectrum drifts lower than 5 pm/min and sensitivities of 518 nm/refractive index unit (RIU) in the visible range of the spectrum were achieved in different electrospun NFs sensors. Full article
(This article belongs to the Special Issue Advanced Photonic Biosensors)
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